Safe and Symptomatic Medicinal Use of Surface-Functionalized Mn
            <sub>3</sub>
            O
            <sub>4</sub>
            Nanoparticles for Hyperbilirubinemia Treatment in Mice

Polley, Nabarun; Saha, Srimoyee; Adhikari, Aniruddha; Banerjee, Sudeshna Ghosh; Darbar, Soumendra; Das, Sukhen; Pal, Samir Kumar

doi:10.2217/nnm.15.83

Cited by 42 publications

(35 citation statements)

References 53 publications

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“…For the synthesis of bulk Mn 3 O 4 NPs at normal temperature and pressure, a previously reported procedure was followed . The as prepared Mn 3 O 4 NPs were functionalized with ligand (citrate) following a technique described earlier . In a nutshell, 5 mL aqueous solution of citrate (0.5 m , pH 7.0) was added to the as prepared Mn 3 O 4 NPs (100 mg) and extensively mixed for 12 h in a cyclomixture.…”

Section: Methodsmentioning

confidence: 99%

A Smart Nanotherapeutic Agent for in vitro and in vivo Reversal of Heavy‐Metal‐Induced Causality: Key Information from Optical Spectroscopy

et al. 2019

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Human exposure to heavy metals can cause a variety of life‐threatening disorders, affecting almost every organ of the body, including the nervous, circulatory, cardiac, excretory, and hepatic systems. The presence of heavy metal (cause) and induced oxidative stress (effect) are both responsible for the observed toxic effects. The conventional and effective way to combat heavy metal overload diseases is through use of metal chelators. However, they possess several side effects and most importantly they fail to manage the entire causality. In this study, we introduce citrate‐functionalized Mn3O4 nanoparticles (C−Mn3O4 NPs) as an efficient chelating agent for treatment of heavy metal overload diseases. By means of UV/Vis absorbance and steady‐state fluorescence spectroscopic techniques we investigated the efficacy of the NPs in chelation of a model heavy metal, lead (Pb). We also explored the retention of antioxidant properties of the Pb‐chelated C−Mn3O4 NPs using a UV/Vis‐assisted DPPH assay. Through CD spectroscopic studies we established that the NPs can reverse the Pb‐induced structural modifications of biological macromolecules. We also studied the in vivo efficacy of NPs in Pb‐intoxicated C57BL/6j mice. The NPs were not only able to mobilize the Pb from various organs through chelation, but also saved the organs from oxidative damage. Thus, the C−Mn3O4 NPs could be an effective nanotherapeutic agent for complete reversal of heavy‐metal‐induced toxicity through chelation of the heavy metal and healing of the associated oxidative stress.

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Section: Methodsmentioning

confidence: 99%

A Smart Nanotherapeutic Agent for in vitro and in vivo Reversal of Heavy‐Metal‐Induced Causality: Key Information from Optical Spectroscopy

et al. 2019

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“…For surface functionalization with citrate, an earlier reported technique was used [1,20]. In brief, as prepared Mn 3 O 4 NP s were added to 0.5 M aqueous ligand (citrate) solution of pH 7.0 (∼20 mg Mn 3 O 4 NPs/ml ligand solution) and extensively mixed for 12 h in a cyclomixer.…”

Section: Methodsmentioning

confidence: 99%

“…Unfortunately, the NPs are not sufficiently effective because of their nonspecific distribution to the entire body, metabolism in the GI tract, low retention in the lesion area and undesired adverse effects [19]. Citrate functionalized Mn 3 O 4 NP (C-Mn 3 O 4 NP) is an inorganic nanoparticle that has previously shown therapeutic promise in safe and symptomatic treatment of hyperbilirubinemia in preclinical models [20]. …”

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confidence: 99%

Citrate Functionalized Mn₃O₄in Nanotherapy of Hepatic Fibrosis by Oral Administration

Adhikari

Polley

Darbar³

et al. 2016

Future Science OA

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Aim:To test the potential of orally administered citrate functionalized Mn3O4 nanoparticles (C-Mn3O4 NPs) as a therapeutic agent against hepatic fibrosis and associated chronic liver diseases.Materials & methods:C-Mn3O4 NPs were synthesized and the pH dependent antioxidant mechanism was characterized by in vitro studies. CCl4 intoxicated mice were orally treated with C-Mn3O4 NPs to test its in vivo antioxidant and antifibrotic ability.Results:We demonstrated ultrahigh efficacy of the C-Mn3O4 NPs in treatment of chronic liver diseases such as hepatic fibrosis and cirrhosis in mice compared with conventional medicine silymarin without any toxicological implications.Conclusion:These findings may pave the way for practical clinical use of the NPs as safe medication of chronic liver diseases associated with fibrosis and cirrhosis in human subjects.

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“…The applications of Nanomedicines have been far and widespread [1,2]. From the development of diagnostic devices [3], analytical tools [4], physical therapy applications [3,5] to therapeutic drug delivery [4][5][6], and targeted drug delivery [5].…”

Section: Introductionmentioning

confidence: 99%

Acute Toxicity Study of Silver Nanoparticle Coupled with Euphorbia thymifolia

Saha¹,

Bala²,

Basu³

et al. 2018

JNST

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Nanomedicine is widely explored nowadays for treatment of life threatening diseases, yet comes with various challenges and questions. The present study encapsulates the acute toxicological aspects of the Euphorbia thymifolia coupled silver nanoparticles (ET-Ag NP). For acute toxicity studies according to OCED (Organization for Economic Cooperation Development) guidelines Swiss Albino mice (6-8 weeks) were used and were given single intraperitoneal dose of 2000 and 5000 mg/kg body weight and were observed for mortality and other side effects for 14 days. The individual components of the formulation, viz. silver oxide in surface modified nano form and at low dose, and Euphorbia thymifolia are both biocompatible materials. No changes were found for general appearance, behavior and body weight, thus concluding that the nanocomposite formulation does not have single dose toxicity.

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Safe and Symptomatic Medicinal Use of Surface-Functionalized Mn ₃ O ₄ Nanoparticles for Hyperbilirubinemia Treatment in Mice

Abstract: These findings may pave the way for practical clinical use of the NPs as safe medication of hyperbilirubinemia in human subjects.

Cited by 42 publications

References 53 publications

A Smart Nanotherapeutic Agent for in vitro and in vivo Reversal of Heavy‐Metal‐Induced Causality: Key Information from Optical Spectroscopy

A Smart Nanotherapeutic Agent for in vitro and in vivo Reversal of Heavy‐Metal‐Induced Causality: Key Information from Optical Spectroscopy

Citrate Functionalized Mn₃O₄in Nanotherapy of Hepatic Fibrosis by Oral Administration

Acute Toxicity Study of Silver Nanoparticle Coupled with Euphorbia thymifolia

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Safe and Symptomatic Medicinal Use of Surface-Functionalized Mn 3 O 4 Nanoparticles for Hyperbilirubinemia Treatment in Mice

Abstract: These findings may pave the way for practical clinical use of the NPs as safe medication of hyperbilirubinemia in human subjects.

Cited by 42 publications

References 53 publications

A Smart Nanotherapeutic Agent for in vitro and in vivo Reversal of Heavy‐Metal‐Induced Causality: Key Information from Optical Spectroscopy

A Smart Nanotherapeutic Agent for in vitro and in vivo Reversal of Heavy‐Metal‐Induced Causality: Key Information from Optical Spectroscopy

Citrate Functionalized Mn3O4in Nanotherapy of Hepatic Fibrosis by Oral Administration

Acute Toxicity Study of Silver Nanoparticle Coupled with Euphorbia thymifolia

Contact Info

Product

Resources

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Safe and Symptomatic Medicinal Use of Surface-Functionalized Mn ₃ O ₄ Nanoparticles for Hyperbilirubinemia Treatment in Mice

Citrate Functionalized Mn₃O₄in Nanotherapy of Hepatic Fibrosis by Oral Administration