Evaluation of neurobehavioral deficits following different severities of cerebral ischemia in rats: A comparison between the modified hole board test and the Morris water maze test

Gordan, M. L.; Jungwirth, Bettina; Ohl, Frauke; Kellermann, Kristine; Kochs, Eberhard; Blobner, Manfred

doi:10.1016/j.bbr.2012.07.027

Cited by 36 publications

(16 citation statements)

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“…MWM test is one of the most commonly used experiments for evaluating memory deficits following hippocampus injury and screening tests for characterizing potential anti-dementia drugs (Gordan et al, 2012;Li et al, 2012;Liu et al, 2011b). Our present results demonstrated that the PSG can obviously improve the learning and memory of Ab 1-40 -induced dementia rats, in a dose-dependent manner.…”

Section: Discussionsupporting

confidence: 58%

Ameliorative effects of physcion 8-O-β-glucopyranoside isolated fromPolygonum cuspidatumon learning and memory in dementia rats induced by Aβ_1–40

Zhou

Zou

et al. 2015

Pharmaceutical Biology

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Section: Discussionsupporting

confidence: 58%

Ameliorative effects of physcion 8-O-β-glucopyranoside isolated fromPolygonum cuspidatumon learning and memory in dementia rats induced by Aβ_1–40

Zhou

Zou

et al. 2015

Pharmaceutical Biology

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“…Second, a variety of behavioral parameters can be evaluated in addition to cognitive parameters in one session, allowing for the assessment of altered motivational systems, which could potentially have an impact on cognitive performance. A recently published direct comparison showed that the MHBT is at least not inferior compared to the Morris water maze in assessing the functional outcome of rats in a model of cerebral ischemia [30].…”

Section: Methodsmentioning

confidence: 99%

Sevoflurane Anesthesia Improves Cognitive Performance in Mice, but Does Not Influence In Vitro Long-Term Potentation in Hippocampus CA1 Stratum Radiatum

et al. 2013

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BackgroundWhether the occurrence of postoperative cognitive dysfunction is a result of the effects of surgery or anesthesia is under debate. In this study, we investigated the impact of sevoflurane anesthesia on cognitive performance and cellular mechanisms involved in learning and memory.MethodsMale C57Bl6/J mice (4–5 months) were exposed to one minimum alveolar concentration sevoflurane for two hours. After 24 h, cognitive performance of mice was assessed using the modified hole board test. Additionally, we evaluated hippocampal long-term potentiation and expression levels of different receptor subunits by recording excitatory postsynaptic field potentials and using the western blot technique, respectively. Non-anesthetized mice served as controls.ResultsIn anesthetized mice, neither cognitive performance nor long-term potentiation was impaired 24 h after anesthesia. Interestingly, sevoflurane anesthesia induced even an improvement of cognitive performance and an elevation of the expression levels of N-methyl-D-aspartate (NMDA) receptor type 1 and 2B subunits in the hippocampus.ConclusionsSince NMDA receptor type 1 and 2B subunits play a crucial role in processes related to learning and memory, we hypothesize that sevoflurane-induced changes in NMDA receptor subunit composition might cause hippocampus-dependent cognitive improvement. The data of the present study are in favor of a minor role of anesthesia in mediating postoperative cognitive dysfunction.

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“…The MWM has been used widely to assess postoperative cognitive deficit [12,13]. In the present study, we evaluated spatial memory impairment by examining swimming latency and distance using the MWM.…”

Section: Minocycline Improved Postoperative Memory Impairmentmentioning

confidence: 99%

Minocycline improves postoperative cognitive impairment in aged mice by inhibiting astrocytic activation

ShanWu¹,

Lu²,

Wenjie³

et al. 2013

NeuroReport

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Astrocytes are proving to be critical for the development of cognitive functions. In addition, astrocytic activation contributes toward cognitive impairment induced by chronic cerebral hypoperfusion. Minocycline has been shown to exhibit long-term neuroprotective effects in vascular cognitive impairment rat models through the inhibition of astrogliosis, and has shown potential for the prevention and treatment of postoperative cognitive decline in elderly patients. This study aimed to examine the effect of minocycline on hippocampal astrocytes and long-term postoperative cognitive dysfunction in aged mice. Mice were injected intraperitoneally with 45 mg/kg minocycline once a day for 30 days after 70% hepatectomy. Hippocampal-dependent spatial memory ability was evaluated using the Morris water maze. The expression levels of hippocampal glial fibrillary acidic protein (GFAP) and ionized calcium-binding adaptor molecule-1 were detected with western blotting, and the hippocampal mRNA relative expression levels of tumor necrosis factor a, interleukin 1 b (IL-1b), and IL-6 were tested using a real-time PCR. The Morris water maze test showed that escape latency and swim distance were prolonged significantly by the surgery, but the extent of impairment was mitigated by minocycline treatment. Hippocampal GFAP and mRNA of tumor necrosis factor a, IL-1b, and IL-6 showed corresponding changes that were consistent with the variations of spatial memory. Minocycline could alleviate hepatectomy-related long-term spatial memory impairment in aged mice, and was associated with reduced levels of hippocampal GFAP and proinflammatory cytokines resulting from astrocytic activation. NeuroReport

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Evaluation of neurobehavioral deficits following different severities of cerebral ischemia in rats: A comparison between the modified hole board test and the Morris water maze test

Cited by 36 publications

References 31 publications

Ameliorative effects of physcion 8-O-β-glucopyranoside isolated fromPolygonum cuspidatumon learning and memory in dementia rats induced by Aβ_1–40

Ameliorative effects of physcion 8-O-β-glucopyranoside isolated fromPolygonum cuspidatumon learning and memory in dementia rats induced by Aβ_1–40

Sevoflurane Anesthesia Improves Cognitive Performance in Mice, but Does Not Influence In Vitro Long-Term Potentation in Hippocampus CA1 Stratum Radiatum

Minocycline improves postoperative cognitive impairment in aged mice by inhibiting astrocytic activation

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Evaluation of neurobehavioral deficits following different severities of cerebral ischemia in rats: A comparison between the modified hole board test and the Morris water maze test

Cited by 36 publications

References 31 publications

Ameliorative effects of physcion 8-O-β-glucopyranoside isolated fromPolygonum cuspidatumon learning and memory in dementia rats induced by Aβ1–40

Ameliorative effects of physcion 8-O-β-glucopyranoside isolated fromPolygonum cuspidatumon learning and memory in dementia rats induced by Aβ1–40

Sevoflurane Anesthesia Improves Cognitive Performance in Mice, but Does Not Influence In Vitro Long-Term Potentation in Hippocampus CA1 Stratum Radiatum

Minocycline improves postoperative cognitive impairment in aged mice by inhibiting astrocytic activation

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Product

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Ameliorative effects of physcion 8-O-β-glucopyranoside isolated fromPolygonum cuspidatumon learning and memory in dementia rats induced by Aβ_1–40

Ameliorative effects of physcion 8-O-β-glucopyranoside isolated fromPolygonum cuspidatumon learning and memory in dementia rats induced by Aβ_1–40