Evaluation of neuroendocrine status in longevity

Baranowska, B; Woliñska-Witort, Ewa; Bik, Wojciech; Baranowska-Bik, Agnieszka; Martyńska, Lidia; Chmielowska, Magdalena

doi:10.1016/j.neurobiolaging.2006.03.014

Cited by 28 publications

(29 citation statements)

References 86 publications

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“…Moreover, the vasoconstrictive properties of NPY may contribute to the mechanism underlying hypertension in obesity (25,26). In aging studies, it was demonstrated that plasma NPY levels and NPY gene expression in the hypothalamus increased with age (17)(18)(19). However, the POMC mRNA levels in the ARC were not found to be affected by age in the basal state, whereas an age-associated increase of CART mRNA in the ARC and an age-associated decrease in CART mRNA in the PVN were previously reported (4).…”

Section: A B Discussionmentioning

confidence: 99%

“…Over the last few years, numerous studies demonstrated that the NPY, CART and POMC mRNA expression levels and the plasma levels of the respective proteins are altered with advancing age (4,(17)(18)(19). However, although it was demonstrated that nesfatin-1 suppresses appetite via the regulation of NPY, CART and POMC, and that adiponectin regulates energy metabolism in association with NPY and POMC (6,7,20), the mechanisms underlying the changes in nesfatin-1 and adiponectin levels with advancing age have not been fully elucidated.…”

Section: Introductionmentioning

confidence: 99%

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Effects of aging on the plasma levels of nesfatin-1 and adiponectin

Nishida

Kaimoto

et al. 2013

Biomedical Reports

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Abstract. Gastric and adipose tissue secrete a number of hormones that are involved in energy metabolism. The biological functions of these hormones, including their effects on aging, are currently under investigation. Adiponectin was shown to be directly involved in appetite and the control of body weight. However, the effects of aging of nesfatin-1, an appetite-suppressing peptide that was recently identified, have not yet been fully elucidated. The aim of this study was to determine the effects of aging on the plasma levels of nesfatin-1 and adiponectin. Our results demonstrated no significant differences in the nesfatin-1 plasma levels among three age groups (2, 6 and 24 months) of female BALB̸c mice. The plasma nesfatin-1 levels̸visceral fat (VF) ratio in the 24-month-old mice was significantly lower compared to that in the 2-and 6-month-old mice. In addition, there were no significant differences in the plasma adiponectin levels among the three age groups. The plasma adiponectin levels̸VF ratio in the 24-month-old mice was significantly lower compared to that in the 2-and 6-month-old mice. In conclusion, there were no age-related changes in the plasma levels of nesfatin-1 and adiponectin, although the ratio of plasma levels of nesfatin-1 and adiponectin per VF was decreased with advancing age. Our results indicated that nesfatin-1 and adiponectin may be involved in controlling energy balance during aging.

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Section: A B Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Effects of aging on the plasma levels of nesfatin-1 and adiponectin

Nishida

Kaimoto

et al. 2013

Biomedical Reports

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“…Hyperprolactinemia prevalence in an unselected normal population has been reported to be 0.4% but can be as high as 17% in a population of women with reproductive problems (6). Hyperprolactinemia is associated with aging in rats (29,89) and in women and men (4,8,77,81,95). Prolactin levels rise during pregnancy and in particular during the last trimester (73) as well as during lactation (94).…”

Section: Discussionmentioning

confidence: 99%

Experimental estrogen-induced hyperprolactinemia results in bone-related hearing loss in the guinea pig

Horner¹,

Cazals²,

Guieu³

et al. 2007

American Journal of Physiology-Endocrinology and Metabolism

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Our group (Horner KC, Guieu R, Magnan J, Chays A, Cazals Y. Neuropsychopharmacology 26: 135–138, 2002) has earlier described hyperprolactinemia in some patients presenting inner ear dysfunction. However, in that study, it was not possible to determine whether hyperprolactinemia was a cause or an effect of the symptoms. To investigate the effect of hyperprolactinemia on inner ear function, we first developed a model of hyperprolactinemia in estrogen-primed Fischer 344 rats and then performed functional studies on pigmented guinea pigs. Hyperprolactinemia induced, after 2 mo, a hearing loss of ∼30–40 dB across all frequencies, as indicated by the compound action potential audiogram. During the 3rd mo, the hearing loss continued to deteriorate. The threshold shifts were more substantial in males than in females. Observations under a dissection microscope revealed bone dysmorphology of the bulla and the cochlea. Light microscopy observations of cryostat sections confirmed bone-related pathology of the bony cochlear bulla and the cochlear wall and revealed morphopathology of the stria vascularis and spiral ligament. Scanning electron microscopy revealed loss of hair cells and stereocilia damage, in particular in the upper three cochlear turns and the two outermost hair cell rows. The data provide the first evidence of otic capsule and hair cell pathology associated with estrogen-induced prolonged hyperprolactinemia and suggest that conditions such as pregnancy, anti-psychotic drug treatment, aging, and/or stress might lead to similar ear dysfunctions.

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“…The reduction in GH secretion with healthy aging begins after this pubertal maximum and is correlated with gradual changes in body composition, which are characterized by an increased percentage of total body and visceral fat, a reduction in muscle mass, an increase in body weight as well as changes in leptin and insulin secretion [14,15] .…”

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confidence: 99%

Effect of Growth Hormone Treatment on Lymphocyte Functions in Old Male Rats

Baeza

Alvarado²,

Ariznavarreta³

et al. 2008

Neuroimmunomodulation

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Introduction: Age-related changes in the communication between the neuroendocrine and the immune system have been scarcely studied. Aging in mammals is associated with an impairment of the immune response, especially regarding lymphocyte functions. Furthermore, the endocrine system is also affected by aging, one of the most significant changes being the decrease in the secretion of several hormones such as growth hormone (GH). Objective: The aim of the present work was to study whether GH replacement therapy in old male rats could improve several lymphocyte functions. Methods: Spleen and axillary node lymphocytes from old (24 months of age) male Wistar rats were used in the present study to investigate the effect of GH (2 mg/kg daily during 10 weeks) on chemotaxis, lymphoproliferative response to the mitogen concanavalin A, interleukin 2 release and natural killer cell activity. Results: We have found that the administration of GH can reduce or even reverse the age-related changes observed in these key immune function parameters. Moreover, we have observed that the recovery of such immune functions is able to reach similar values as those exhibited by young control animals of 6 months of age. Conclusion: Considering that the immune system is a marker of health and a predictor of longevity, hormone replacement therapies with GH, by increasing the immune function and thus delaying or slowing down some aspects of the aging process, could facilitate successful aging.

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Evaluation of neuroendocrine status in longevity

Cited by 28 publications

References 86 publications

Effects of aging on the plasma levels of nesfatin-1 and adiponectin

Effects of aging on the plasma levels of nesfatin-1 and adiponectin

Experimental estrogen-induced hyperprolactinemia results in bone-related hearing loss in the guinea pig

Effect of Growth Hormone Treatment on Lymphocyte Functions in Old Male Rats

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