Evaluation of New Strategies for the Diagnosis of Tuberculosis Among Pediatric Contacts of Tuberculosis Patients

Pérez-Porcuna, Tomàs; Ascaso, Carlos; Ogusku, Maurício Morishi; Abellana, Rosa; Malheiro, Adriana; Quincó, Patrícia de Lima; Antunes, Irineide Assumpção; Monte, R Comet; Tavares, Michel Araújo; Garrido, Marlucia da Silva; Bührer-Sékula, Samira; Martínez-Espinosa, Flor Ernestina

doi:10.1097/inf.0b013e31825cbb3b

Cited by 6 publications

(13 citation statements)

References 37 publications

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“…24 New diagnostic strategies in this age group are needed and new culture and molecular techniques are emerging as promising resources. 25,26 Moreover, vulnerability of children in this context is high and is probably also influencing the outcomes. A higher number of male TB cases were found.…”

Section: Discussionmentioning

confidence: 99%

Implementation challenges of a TB programme in rural northern mozambique: evaluation of 2012–2013 outcomes

Wikman-Jorgensen

Morales-Cartagena

Llenas-García

et al. 2015

Pathogens and Global Health

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Background: We aimed to identify challenges and to propose solutions for the implementation of tuberculosis (TB) programmes in rural Sub-Saharan Africa (SSA) by evaluating the outcomes of the TB programme in the Ancuabe district in rural Northern Mozambique. Methods: Retrospective descriptive study of the patients included in the TB programme in 2012-2013. Follow-up was continued till June 2014. Results: Three hundred nineteen patients were registered, 62.1% male, mean age 36.3 (SD 14.4), estimated case detection rate (eCDR) of 24.24%. Two hundred seventy-two were new cases, 21 transferred-in, 11 back after lost to follow-up (LTFU), 10 relapsing TB, 5 previous treatment failures. 94.4% were tested for Human immunodeficiency virus (HIV), 41.9% HIV-positive. 87.5% of the new cases were pulmonary TB (PTB), 43.4% were HIV co-infected. Initial sputum results were available in 207 cases, with 145 smear-positive (SP) cases. Outcomes of new cases: 122 (44.9%) LTFU, 55 (20.2%) cured, 43 (15.8%) treatment completed (98-36%-treatment success), 31 (11.4%) died, 19 (7%) transferred out and 2 (0.7%) failures. Conclusions: A low eCDR and high proportion of LTFU demonstrate that few patients were identified and had a low probability of complete treatment, suggesting a fragile health system. This raises the hypothesis that, probably, to improve TB health care in rural SSA, interventions should aim at improving health systems. Special attention should be given to social protection and compensation of the financial burden associated with TB.

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Section: Discussionmentioning

confidence: 99%

Implementation challenges of a TB programme in rural northern mozambique: evaluation of 2012–2013 outcomes

Wikman-Jorgensen

Morales-Cartagena

Llenas-García

et al. 2015

Pathogens and Global Health

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“…Os estudos apontam sobre algumas limitações no diagnóstico da TB em crianças, dentre elas há a dificuldade em obter amostras de escarro, principalmente em indivíduos com menos de 5 anos por, geralmente, não conseguirem expectorar; a inespecificidade das manifestações clínicas iniciais que podem ser confundidas com outros quadros infecciosos ou até mesmo uma desnutrição e, muitas vezes, a suspeita de TB só ocorre nos casos de pneumonia que não apresenta melhora com o uso de antibióticos para microorganismos comuns (Chen et al, 2013;Chiappini et al, 2016;Cruz & Velásquez, 2012;Graham, 2011;Laniado-Laborin, 2015;Perez-Porcuna et al, 2012;Rahman et al, 2012;Rossoni;Reuter;Sant'Anna, 2012;Shingadia, 2012;Venturini et al, 2015).…”

Section: Discussionunclassified

Tuberculose em crianças: desafios no diagnóstico

Santos

Feitosa

Branco

et al. 2022

RSD

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A tuberculose (TB), apesar da existência de vacina e tratamentos efetivos, ainda é um grande desafio à saúde pública e as crianças são significativamente afetadas por não terem a doença previamente identificada. Diante disso, este estudo teve como objetivo descrever acerca das limitações existentes nos exames diagnósticos da TB em crianças, de acordo com a literatura nacional e internacional. Trata-se de uma revisão integrativa que foi realizada utilizando as bases de dados Lilacs, PubMed, Scopus, Embase e Web of Science com descritores indexados e os seus respectivos sinônimos no DeCS, Mesh e Emtree, a partir da questão norteadora “Quais as limitações existentes nos exames diagnósticos para a detecção de TB em crianças que dificultam sua comprovação?”. Foram analisados títulos e resumos dos materiais que atendiam aos seguintes critérios de inclusão: artigos completos, publicados em português, inglês e espanhol nos últimos 10 anos, excluindo-se aqueles que não se caracterizavam como artigos científicos e duplicados. Foram selecionados 26 artigos, os quais reforçaram a importância da associação entre o teste tuberculínico, fatores epidemiológicos, radiológicos e quadro clínico para elucidação diagnóstica da TB que geralmente são realizados pelos serviços especializados, considerando a complexidade de elucidação diagnóstica e acompanhamento destes casos, uma vez que o subdiagnóstico pode interferir na qualidade de vida e conduta adequada.

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“…The difference between BBL MGIT and LJ culture was statistically significant (p<0.0001). In a recent study done by Pérez-Porcuna et al (18) The time of culture positivity in MGIT was a median of 14 days, 48 days for the LJ cultures, being 3-fold more rapid in the former than in the latter (P < 0.0001).…”

Section: Direct Microscopic Examination Of Clinical Samples By Ziehl-mentioning

confidence: 90%

Evaluation of Serodiagnosis of Tuberculosis in Comparison with Traditional Methods

Shafik¹,

Morgan²,

Youssef³

2013

EJMM

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Tuberculosis is an enormous tool of morbidity and mortality. The vast majority of tuberculosis patients live in developing countries, where the diagnosis of tuberculosis relies on the identification of acid-fast bacilli on unprocessed sputum smears using conventional light microscopy. Microscopy has high specificity in tuberculosis-endemic countries, but modest sensitivity which varies among laboratories (range 20% to 80%).. Thus, the development of rapid and accurate new diagnostic tools is imperative. Immune-based tests are potentially suitable for use in low-income countries as some test formats can be performed at the point of care .In the present study, the diagnostic value of 16-kDa and 38-kDa mycobacterial antigens was investigated in patients who were diagnosed as open pulmonary tuberculosis. The humoral immune response was analysed in a group of 60 TB patients, and in control group consisting of 15 healthy volunteers and 15 subjects with pulmonary diseases other than TB. The sensitivity, specifity, positive predictive value and negative predictive value of the test were determined at 45%, 93.3%, 93.1% and 45.9%, respectively. In conclusion, the ELISA test has a very good specifity and an acceptable sensitivity and positive predictive value. It is thought that it could be used in combination with other methods to increase diagnostic accuracy, especially for culture-negative tuberculosis cases, which are difficult to diagnose.

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Evaluation of New Strategies for the Diagnosis of Tuberculosis Among Pediatric Contacts of Tuberculosis Patients

Cited by 6 publications

References 37 publications

Implementation challenges of a TB programme in rural northern mozambique: evaluation of 2012–2013 outcomes

Implementation challenges of a TB programme in rural northern mozambique: evaluation of 2012–2013 outcomes

Tuberculose em crianças: desafios no diagnóstico

Evaluation of Serodiagnosis of Tuberculosis in Comparison with Traditional Methods

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