Evaluation of nine surface disinfectants against <i>Candida auris</i> using a quantitative disk carrier method: EPA SOP-MB-35

Sexton, D. Joseph; Welsh, Rory M.; Bentz, Meghan L.; Forsberg, Kaitlin; Jackson, Brendan R; Litvintseva, Anastasia P.

doi:10.1017/ice.2020.278

Cited by 25 publications

(42 citation statements)

References 6 publications

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“…C. auris isolates from the 2 clades were studied because a recent report suggested that a clade IV isolate of C. auris (AR 0385) was less susceptible to low concentrations of sodium hypochlorite than a clade II isolate (AR 0381). 8 Testing was completed in triplicate. Log 10 colony-forming unit (CFU) reductions were calculated by comparing recovery from treated versus untreated control carriers.…”

Section: Methodsmentioning

confidence: 99%

Effectiveness and real-world materials compatibility of a novel hydrogen peroxide disinfectant cleaner

Cadnum

Pearlmutter

Haq

et al. 2021

American Journal of Infection Control

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A novel 4% hydrogen peroxide disinfectant was effective against methicillin-resistant Staphylococcus aureus (MRSA), Clostridioides difficile spores, carbapenem-resistant Escherichia coli, and 2 strains of Candida auris. In laboratory testing, a sodium hypochlorite disinfectant caused fading and loss of pliability of a hospital mattress, but the hydrogen peroxide disinfectant did not. These findings suggest that the hydrogen peroxidebased disinfectant may be a useful addition to the sporicidal disinfectant products available for use in healthcare settings.

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Section: Methodsmentioning

confidence: 99%

Effectiveness and real-world materials compatibility of a novel hydrogen peroxide disinfectant cleaner

Cadnum

Pearlmutter

Haq

et al. 2021

American Journal of Infection Control

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“…auris colonisation in this study was the axillary temperature monitoring with contaminated reusable digital thermometers. These findings may be related to the use of quaternary ammonium disinfection, 22 and most patients hospitalised during the outbreak were admitted due to severe COVID‐19 and had a similar clinical course.…”

Section: Discussionmentioning

confidence: 93%

“…auris ‐colonised patients that were isolated and put in contact precautions. These measures, along with the substitution of disinfection products based on quaternary ammonium by sodium hypochlorite and hydrogen peroxide‐based disinfectants, 22 and replacement of all digital thermometers by infrared ones were instituted. Despite all these measures, the outbreak was not controlled, and additional screening cultures are under evaluation.…”

Section: Discussionmentioning

confidence: 99%

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Axillary Digital Thermometers uplifted a multidrug‐susceptible Candidaauris outbreak among COVID‐19 patients in Brazil

Almeida

Brandão

Francisco

et al. 2021

Mycoses

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Objectives To describe the first outbreak of Candida auris in Brazil, including epidemiological, clinical and microbiological data. Methods After the first Candida auris ‐colonised patient was diagnosed in a COVID‐19 ICU at a hospital in Salvador, Brazil, a multidisciplinary team conducted a local C . auris prevalence investigation. Screening cultures for C . auris were collected from patients, healthcare workers and inanimate surfaces. Risk factors for C . auris colonisation were evaluated, and the fungemia episodes that occurred after the investigation were also analysed and described. Antifungal susceptibility of the C . auris isolates was determined, and they were genotyped with microsatellite analysis. Results Among body swabs collected from 47 patients, eight ( n = 8/47, 17%) samples from the axillae were positive for C . auris . Among samples collected from inanimate surfaces, digital thermometers had the highest rate of positive cultures ( n = 8/47, 17%). Antifungal susceptibility testing showed MICs of 0.5 to 1 mg/L for AMB, 0.03 to 0.06 mg/L for voriconazole, 2 to 4 mg/L for fluconazole and 0.03 to 0.06 mg/L for anidulafungin. Microsatellite analysis revealed that all C . auris isolates belong to the South Asian clade (Clade I) and had different genotypes. In multivariate analysis, having a colonised digital thermometer was the only independent risk factor associated with C . auris colonisation. Three episodes of C . auris fungemia occurred after the investigation, with 30‐day attributable mortality of 33.3%. Conclusions Emergence of C . auris in Salvador, Brazil, may be related to local C . auris clade I closely related genotypes. Contaminated axillary monitoring thermometers may facilitate the dissemination of C . auris reinforcing the concept that these reusable devices should be carefully cleaned with an effective disinfectant or replaced by other temperature monitoring methods.

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“…The United States Center for Disease Control and Prevention (CDC) identifies C. auris as a major global threat, with fatality rates in immunocompromised individuals ranging from 10-60% [1] . Finding safe and effective non-toxic disinfectants against C. auris has proven difficult [2] , [3] , [4] , [5] , [6] . The plant oil Isomerized Linoleic acid has maintained Generally Recognized as Safe (GRAS) status as a food additive since 2008 [7] .…”

Section: Introductionmentioning

confidence: 99%

Potassium isomerized linoleate satisfies EPA MB-35-00 for surface disinfection ofCandida auris(AR-0381)

Changaris¹,

Carenbauer²

2021

Preprint

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Four distinct lots of Potassium Isomerized Linoleate, 442 mM or 141 mg/ml (within the cosmetic-cleanser and commercial-soap acceptable concentration ranges but much greater than physiologic conditions), showed greater than 5 log kill rates (total) for Candida auris (AR-0381) for all carriers during 5 separate procedural runs of EPA MB-35-00. After exposing the inoculated stainless-steel carriers to the plant-oil soap for 1, 2, or 10 minute(s), we recovered no Candida auris on these tested carriers. Control carriers with phosphate-buffered saline applied, recovered 5.0-6.8 Log of colony-forming units per carrier.

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Evaluation of nine surface disinfectants against Candida auris using a quantitative disk carrier method: EPA SOP-MB-35

Cited by 25 publications

References 6 publications

Effectiveness and real-world materials compatibility of a novel hydrogen peroxide disinfectant cleaner

Effectiveness and real-world materials compatibility of a novel hydrogen peroxide disinfectant cleaner

Axillary Digital Thermometers uplifted a multidrug‐susceptible Candidaauris outbreak among COVID‐19 patients in Brazil

Potassium isomerized linoleate satisfies EPA MB-35-00 for surface disinfection ofCandida auris(AR-0381)

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