Evaluation of Non-lactose-fermenting Members of the Klebsiella–Enterobacter–Serratia Division: II. Antibiotic Susceptibility

Oberhofer, Thomas R.; Hajkowski, Ruta

doi:10.1093/ajcp/54.5.726

Cited by 12 publications

(6 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…These findings correspond to previous reports concerning the efficacy-of these antibiotics (4,6,10,12). Ampicillin, cephalothin, tetracycline, and colistin are ineffective in vitro and do not appear to be useful in the treatment of Serratia infections.…”

Section: Discussionsupporting

confidence: 90%

“…The ability of this opportunistic pathogen to acquire resistance to a broad range of antibiotics has made effective therapy more difficult. Several recent investigations have dealt with the problem of antibiotic resistance in Serratia (3,4,6,(10)(11)(12)(13). The overall findings of these studies indicate that the polymyxins and cephalosporins are the least effective agents against Serratia in vitro, and although gentamicin, kanamycin, chloramphenicol, and nalidixic acid are the most effective, resistance to kanamycin and chloramphenicol, as well as the p-lactam antibiotics, has increased during the last decade.…”

mentioning

confidence: 99%

“…(12) with an inoculum of approximately 5 X 104 bacteria. The MIC was defined as the lowest concentration of drug preventing visible growth after 18 h of incubation at 37 C. Table 1 gives the results of disk sensitivity testing for the 102 Serratia strains isolated.…”

mentioning

confidence: 99%

See 2 more Smart Citations

Antibiotic Resistance Patterns of Clinical Isolates of Serratia marcescens

Rc¹,

Er²,

1975

Antimicrob Agents Chemother

View full text Add to dashboard Cite

Antimicrobial susceptibility patterns of 102 clinical isolates of Serratia marcescens from three medical centers were studied by using disk sensitivity and agar dilution methods. The least resistance was demonstrated against gentamicin, nalidixic acid, chloramphenicol, and sulfisoxazole, all of which inhibited more than 80% of the strains. Cephalothin was completely ineffective, and more than 90% of strains were resistant to ampicillin and tetracycline. As demonstrated by the agar dilution method, the minimal inhibitory concentration of nalidixic acid, gentamicin, tobramycin, and chloramphenicol for most strains fell within therapeutically attainable concentrations. The prevalence of resistance to ampicillin, cephalothin, and tetracycline was nearly the same at all three medical centers, whereas there appeared to be patterns characteristic for each center with regard to the other drugs used. Eleven of the isolates produced pigment and exhibited patterns similar but not identical to those of the nonpigmented strains, all 11 being resistant to between three and six drugs. Half of the strains were resistant to five or more antibiotics, indicating that some Serratia exhibit resistance to an unusually broad range of therapeutic agents.

show abstract

Section: Discussionsupporting

confidence: 90%

mentioning

confidence: 99%

See 1 more Smart Citation

Antibiotic Resistance Patterns of Clinical Isolates of Serratia marcescens

Rc¹,

Er²,

1975

Antimicrob Agents Chemother

View full text Add to dashboard Cite

show abstract

“…Die Gentamicin-Aktivität gegen Proteus-Bakterien, speziell Proteus mirabilis, ist schon früher nicht als sehr günstig beurteilt worden [2,7,16,18,20 Nach D avis et al [3] sind 73 %> der Serratia-marcescens-lso\ate gent amicinsensibel; auch andere Untersucher [5,17,24,25,29,30] betonen, dass Gentamicin von den wenigen gegen Serratia marcescens in Frage kommenden Antibiotika das noch am besten wirksame ist. Die von uns erhaltenen Ergebnisse können als Bestätigung der von den Vorunter suchern mitgeteilten Befunde dienen.…”

Section: D)unclassified

Die Gentamicin-Sensibilität der gramnegativen «Problemkeime» und Staphylokokken, nachgewiesen mittels Reihenverdünnungstest

Modde¹

1972

Pathobiology

View full text Add to dashboard Cite

A total of 716 strains of the following bacterial species have been tested for their susceptibility to gentamicin: 114 Pseudomonas pyocyanea, 100 Escherichia coli, 100 Proteus mirabilis, 100 Klebsiella pneumoniae, 100 Staphylococcus aureus, 59 Proteus morganii, 45 Proteus vulgaris, 39 Serratia marcescens, 29 Salmonella of the Enteritis group, 17 Salmonella typhi, 7 Salmonella paratyphi B, 6 Proteus rettgeri. Using a tube dilution method it was illustrated that, except for Proteus mirabilis, gentamicin susceptibility of the tested strains remains basically unchanged and favorable. Bacteriostatic and bactericidal concentrations of the drug proved to be very close, if not identical. Since there is, in single cases, a possibility of development of resistance even in usually gentamicin-susceptible germs, sensitivity testing is recommended in each treatment with this antibiotic.

show abstract

“…Investigations of drug resistance in this species have shown Serratia to have resistance to a broader range of therapeutic agents than other Enterobacteriaceae (5,7,9,13). The contribu-.…”

mentioning

confidence: 99%

R Factor-Mediated Antibiotic Resistance in Serratia marcescens

Cooksey¹,

Thorne²,

Farrar

1976

Antimicrob Agents Chemother

View full text Add to dashboard Cite

Nineteen of 39 multiresistant strains of Serratia marcescens isolated from clinical sources transferred antibiotic resistance toEscherichia coli orKlebsiella pneumoniae recipients. Marcesins and/or phage prevented effective resistance transfer to E. coli and attempts to select marcescin-resistant mutants of the E. coli recipient strain were unsuccessful. Transfer of resistance was demonstrated for all drugs tested except nalidixic acid. Approximately 90% of donors resistant to tobramycin, ampicillin, or carbenicillin transferred resistance to these drugs.High levels of transferred resistance (minimal inhibitory concentration, >2,500 ,ug/ml) were demonstrated particularly for ampicillin, carbenicillin, and kanamycin. Transmissibility of Serratia R factors was greatest betwween isogeneic strains of E. coli K-12. Comparative rates of spontaneous loss of R factormediated resistance indicated that Serratia R factors are less stable in E. coli and K. pneumoniae transcipients than in the indigenous hosts.The incidence of hospital-associated infections caused by Serratia marcescens has increased significantly in recent years (3, 4, 13). Investigations of drug resistance in this species have shown Serratia to have resistance to a broader range of therapeutic agents than other Enterobacteriaceae (5, 7, 9, 13). The contribu-. tion of R factors to the multiple resistance of Serratia was studied in 1969 by Medeiros and O'Brien (8) who found that 21 of 22 multipleresistant isolates transferred at least part of their resistance. They also concluded that multiple drug resistance is more prevalent in Serratia than in any other comxnonly isolated member of the Enterobacteriaceae, and that R factors not only mediated resistance to drugs to which the strain was previously susceptible but also conferred additional degrees of resistance to drugs to which the organism was already resistant.Recently, 236 strains of Serratia marcescens obtained from Europe, Canada, and the United States were tested for R factor compatibility groups and transferability to Escherichia coli (7). Only 27 strains transferred resistance; the R factors found belonged either to compatibility groups notable for their wide generic host range or to groups found only in Serratia.In this study 39 multiresistant strains of S. marcescens isolated from clinical sources were studied to evaluate the prevalence, antibiotic resistance patterns, transmissibility, and stability of R factors in S. marcescens and in E. coli and Klebsiella pneumoniae transcipients.MATERIALS AND METHODS Donors. From a collection of 102 strains of S. marcescens isolated from clinical sources at three medical centers (1), 39 multiresistant strains were selected for study. These strains were either resistant to antibiotics to which most strains in the collection were susceptible (streptomycin and kanamycin minimal inhibitory concentrations [MICs] :2 80 ,tg/ ml; chloramphenicol MIC 2 30 ,lg/ml; gentamicin and tobramycin MICs 2 16 ,ug/ml) or were resistant to unusually high levels of ampicillin or t...

show abstract

Evaluation of Non-lactose-fermenting Members of the Klebsiella–Enterobacter–Serratia Division: II. Antibiotic Susceptibility

Cited by 12 publications

References 0 publications

Antibiotic Resistance Patterns of Clinical Isolates of Serratia marcescens

Antibiotic Resistance Patterns of Clinical Isolates of Serratia marcescens

Die Gentamicin-Sensibilität der gramnegativen «Problemkeime» und Staphylokokken, nachgewiesen mittels Reihenverdünnungstest

R Factor-Mediated Antibiotic Resistance in Serratia marcescens

Contact Info

Product

Resources

About