Evaluation of nucleolar organizer region (NOR) parameters in the uterine leiomyoma

Madej, Paweł; Madej, Janusz A.; Plewka, Andrzej; Kazimierczak, Wojciech; Dzimira, Stanisław

doi:10.1016/j.prp.2005.05.014

Cited by 2 publications

(1 citation statement)

References 20 publications

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“…In a similar manner expression of cdks (cdk2 and edk2), cyclins E and A, p16 protein, metallothionein 2 and PG receptor were higher in myosarcoma than in SMTUMP [18]. In both types of tumours AgNORs [25], PCNA, HER-2/neu, p53 protein and MDM -2 were studied and the indiced proved to be of a high diagnostic value. In serum levels of lactic dehydrogenase (LDH) and of isoenzymes, particularly of LDH3 type, were higher in myosarcoma than in myomas.…”

Section: Myoma and Leiomyoma -Presence Of Dis-oric Zonementioning

confidence: 73%

Pathomorphosis of Uterine Myomas in Women

Madej¹,

Madej²

2008

TOPATJ

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Taking stroma (ECM-extracellular matrix) and not tumour parenchyma as a criterion of categorization, the tumours can be divided into two groups, i.e. those which produce stroma (non-epithelial malignant tumours) or sarcomas and the tumours which take advantage of the local tissue stroma (malignant epithelial tumours) or carcinomas. Involvement of stroma is noted also within the reciprocal relationship between stroma and tumour cells, which has been described in detail on the example of uterine myoma. ECM also "collaborates" with CAM (cell adhesion molecules), particularly in development of neoplastic metastases.Pathomorphosis of myomas, myosarcomas and of "stromal" uterine tumours was described with particular attention given to differential diagnosis and the resulting clinic predictive and prognostic implications. A probable mechanism of neoplasia based on dissipative structures of cells was presented and introduction of a disoric zone of a tumour, i.e. of a marginal zone between the tumour and the morphologically normal tissue was suggested. The zone seems extremely important in prediction and prognosis related to relapse and/or tumour metastases.

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Section: Myoma and Leiomyoma -Presence Of Dis-oric Zonementioning

confidence: 73%

Pathomorphosis of Uterine Myomas in Women

Madej¹,

Madej²

2008

TOPATJ

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Prognostic Value of Microvessel Density in Tumor and Peritumoral Area as Evaluated by CD31 Protein Expression and Argyrophilic Nucleolar Organizer Region Count in Endothelial Cells in Uterine Leiomyosarcoma

Avdalyan

Бобров

Климачев

et al. 2012

Sarcoma

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The objective of this study was to investigate the prognostic value of microvessel density (MVD) in uterine leiomyosarcoma (LMS) and peritumoral area (PA) as evaluated by CD31 expression and argyrophilic nucleolar organizer region (AgNOR) count in endothelial cells. Tissue specimens from 66 patients with uterine LMS were examined. There were no significant differences in the mean MVD between tumor itself and the PA (P = 0.9); moreover, the MVD in the PA often exceeded that in the tumor. No correlation or significant differences were also found in the MVD between different grades of malignancy of LMS (r = 0.1; P = 0.07). The number of AgNORs in tumor endothelial cells was significantly higher in tumor vessels than in the peritumoral area (P < 0.005) and increased with the tumor grade. Analysis of the prognostic value of MVD in uterine LMS and PA showed that the density of tumor vessels was not an independent criterion, while the MVD in the PA affected 10-year survival to a significantly greater extent (χ 2 = 27.5; P = 0.0003). The number of AgNORs also had an important effect on survival of LMS patients: when the threshold of 11.6 granules was exceeded, prognosis was significantly more unfavorable than that prior to exceeding the threshold.

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Evaluation of nucleolar organizer region (NOR) parameters in the uterine leiomyoma

Cited by 2 publications

References 20 publications

Pathomorphosis of Uterine Myomas in Women

Pathomorphosis of Uterine Myomas in Women

Prognostic Value of Microvessel Density in Tumor and Peritumoral Area as Evaluated by CD31 Protein Expression and Argyrophilic Nucleolar Organizer Region Count in Endothelial Cells in Uterine Leiomyosarcoma

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