Evaluation of nutritional risk factors in hematopoietic stem cell transplantation-eligible patients

Satellite Cells Exhibit Decreased Numbers and Impaired Functions on Single Myofibers Isolated from Vitamin B6-Deficient Mice

“…Interestingly, among the 13 vitamins for humans, vitamin D is the only one that has been extensively studied at both physiological and cellular levels. However, recent research suggests that other nutrients, such as antioxidants, manganese, vitamin A, vitamin E, and vitamin B6, also play a role in the prevention or improvement of sarcopenia [4,[7][8][9][10][11][12][13]. Recent human studies (2016-2021) in European countries as well as Japan have demonstrated that the low intake and low levels of vitamin B6 coexist with sarcopenia [7][8][9][10][11].…”

“…However, recent research suggests that other nutrients, such as antioxidants, manganese, vitamin A, vitamin E, and vitamin B6, also play a role in the prevention or improvement of sarcopenia [4,[7][8][9][10][11][12][13]. Recent human studies (2016-2021) in European countries as well as Japan have demonstrated that the low intake and low levels of vitamin B6 coexist with sarcopenia [7][8][9][10][11]. In 2021, Grootswagers et al [8] reported that increased vitamin B6 intake in older European people is related to improvements in the chair rest test, thereby reflecting muscle power, as well as handgrip strength, which reflects muscle strength.…”

“…Interestingly, among the 13 vitamins in humans, only vitamin D has been extensively studied at both physiological and muscle cell levels. However, emerging research over the last 5 years suggests that other nutrients and vitamins may be potentially involved in sarcopenia [4,[7][8][9][10][11][12][13]. In fact, human studies in both European countries and Japan have demonstrated that low intake as well as low levels of vitamin B6 coexist with sarcopenia [7][8][9][10][11].…”

“…However, emerging research over the last 5 years suggests that other nutrients and vitamins may be potentially involved in sarcopenia [4,[7][8][9][10][11][12][13]. In fact, human studies in both European countries and Japan have demonstrated that low intake as well as low levels of vitamin B6 coexist with sarcopenia [7][8][9][10][11]. Although these reports provide crucial evidence for the association of vitamin B6 with sarcopenia, the evidence has largely been obtained from observational studies.…”

“…Subsequently, we cultured the myofibers for 0, 24, 48, and 72 h and ultimately observed the number and function of the satellite cells on them. Since the main function of vitamin B6 is to be a cofactor for enzymes required in amino acid metabolism [14,15], its deficiency is suspected to affect amino acid and protein synthesis in sarcopenia [7,8,11]. Therefore, we further examined whether vitamin B6 deficiency can induce changes in the levels of amino acids and major muscle protective peptides, namely carnosine and anserine, in skeletal muscles.…”