Evaluation of Occupational Exposure to N-Nitrosamines in a Rubber-Manufacturing Industry

Iavicoli, Ivo; Carelli, G

doi:10.1097/01.jom.0000200938.96781.64

Cited by 24 publications

(16 citation statements)

References 18 publications

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“…and Poland (41,42); and half of the rubber workers in this study exceeded the German target value, the only available exposure limit (31). N-nitrosamines have been reported to induce oxidative stress and DNA damage (43)(44)(45)(46), and the main mechanism suggested for N-nitrosamine carcinogenesis is through the formation of DNA adducts that can cause mutations (47,48).…”

Section: Et Almentioning

confidence: 99%

N–nitrosamines are associated with shorter telomere length

Li¹,

Jönsson²,

Lindh³

et al. 2011

Scand J Work Environ Health

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Section: Et Almentioning

confidence: 99%

N–nitrosamines are associated with shorter telomere length

Li¹,

Jönsson²,

Lindh³

et al. 2011

Scand J Work Environ Health

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“…In environmental surveys of a number of European rubber factories De Vocht et al (26) and Jönsson et al (27) found average N -nitrosamine levels well below current regulatory limits, although exposure has not completely been eliminated and accidental high exposures still occur. High urinary levels of N -nitrosamines have been detected in exposed workers (28). Recent studies have reported a strong correlation between N -nitrosamine exposure and telomere shortening among workers in the rubber industry.…”

Section: Resultsmentioning

confidence: 99%

Non-infective occupational risk factors for hepatocellular carcinoma: A review

Ledda

Loreto

Zammit

et al. 2016

Molecular Medicine Reports

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Liver cancer is the second leading worldwide cause of cancer-associated mortalities. Hepatocellular carcinoma, which accounts for the majority of liver tumors, ranks fifth among types of human cancer. Well-established risk factors for liver cancer include the hepatitis B and C viruses, aflatoxins, alcohol consumption, and oral contraceptives. Tobacco smoking, androgenic steroids, and diabetes mellitus are suspected risk factors. Current knowledge regarding non-infective occupational risk factors for liver cancer is inconclusive. The relevance of liver disorders to occupational medicine lies in the fact that the majority of chemicals are metabolized in the liver, and toxic metabolites generated via metabolism are the predominant cause of liver damage. However, their non-specific clinical manifestations that are similar in a number of liver diseases make diagnosis difficult. Furthermore, concomitant conditions, such as viral hepatitis and alcohol or drug abuse, may mask liver disorders that result from occupational hepatotoxic agents and block the demonstration of an occupational cause. The identification of environmental agents that result in human cancer is a long and often difficult process. The purpose of the present review is to summarize current knowledge regarding the association of non-infective occupational risk exposure and HCC, to encourage further research and draw attention to this global occupational public health problem.

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“…Only aromatic amine and inhalable aerosol exposure were considered in these analyses whilst exposure to other airborne chemicals generated in the manufacturing process that have been associated to cancer, such as rubber fumes, but also for example nnitrosamines and solvents [4,12,13,45,46,51], have not been taken into account. This could theoretically have resulted in erroneous conclusions on aetiological mechanisms if these other exposures were highly correlated with aromatic amine or inhalable aerosol exposure; for example for solvents [47][48][49] in the Component Assembly departments or n-nitrosamines in the Curing departments [4].…”

Section: Discussionmentioning

confidence: 99%