Evaluation of olibanum and its resin as rate controlling matrix for controlled release of diclofenac

Chowdary, K. P. R.; Mohapatra, Prithwiraj; Krishna, M. N. Murali

doi:10.4103/0250-474x.27826

Cited by 30 publications

(23 citation statements)

References 1 publication

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“…Tramadol release from the prepared matrix tablets followed either concentration dependent or independent kinetics, and non-Fickian mechanism. The observed non-Fickian mechanism of drug release was in contrast to the findings of Chowdary et al 16 who reported a Fickian mechanism of drug release. This deviation could possibly related to the nature of polymer matrix.…”

Section: Model Dependent and Independent Analysiscontrasting

confidence: 99%

“…The difference in drug release between formulations is further supported by MDT values wherein F1 exhibited a lower MDT (112.5 min) than F2 and F3 (Table 2). Similar release profile for diclofenac sodium using resin extracted from gum olibanum was reported by Chowdary et al 16 With increase in the concentration of gum olibanum in the matrix prepared with combinations of polymers, drug release increased. This observed phenomenon is best explained on the basis of the hydrophilic properties of the polymers.…”

Section: Model Dependent and Independent Analysissupporting

confidence: 82%

“…This deviation could possibly related to the nature of polymer matrix. While Chowdary et al 16 used extracted resin from gum olibanum as matrix in the present study untreated gum olibanum was evaluated. Change in solubility profile of drugs and nature of the resin alter the mechanism of drug release from the matrix tablets.…”

Section: Model Dependent and Independent Analysismentioning

confidence: 99%

“…The resin is composed of a resin acid (boswellic acid) and resene (olibamoresena) in equal proportions. 16 Chowdary et al 16 reported matrix forming ability of resin of gum olibanum using diclofenac as model drug. But study was limited and the formulation variables were not investigated.…”

Section: Introductionmentioning

confidence: 99%

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Evaluation of Hydrophilic Polymers and their Combinations in Formulation of Sustained-Release Matrix Tablets of Water-Soluble Drug

Manjula¹,

Srinatha²,

Sridhar³

2014

IJPER

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Aim of the work: The present study was aimed to investigate matrix-forming property of gum olibanum for sustained-release tablets of tramadol, a freely water-soluble drug. The possible synergistic effect of gum olibanum with hydroxypropyl methylcellulose (HPMC) and xanthan gum, and widely used pharmaceutical excipients on tablet properties was investigated. Methods: Matrix tablets were prepared containing polymers, either alone or in combinations, by wet granulation. Tablets were evaluated for their physico-mechanical properties, drug release and hydration properties. Results: Tablets swelling increased till ~3-4 h this was followed by a decline phase. Drug release from the matrix tablets was dependent on the concentration of gum olibanum. Formulation with drug: gum olibanum in 1:2 released 94.37±2.37% drug in 6 h. The drug release data was analyzed by model dependent and model independent equations. Combination of gum olibanum with HPMC or xanthan gum matrices significantly (p<0.05) modulated drug release, which was reflected by the mean dissolution times (MDTs). Incorporation of lactose induced faster drug release compared to dicalcium phosphate and microcrystalline cellulose. Drug release largely followed first-order kinetics and non-Fickian type of diffusion.

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Section: Model Dependent and Independent Analysiscontrasting

confidence: 99%

Section: Model Dependent and Independent Analysissupporting

confidence: 82%

Section: Model Dependent and Independent Analysismentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Evaluation of Hydrophilic Polymers and their Combinations in Formulation of Sustained-Release Matrix Tablets of Water-Soluble Drug

Manjula¹,

Srinatha²,

Sridhar³

2014

IJPER

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“…Ether soluble resin extracted from olibanum exhibited excellent release retarding properties in microentrapment for controlled release due to its hydrophobic water repellant properties. Preliminary studies indicated that the resin has good film forming property when dried from chloroform 7 solution . In the present work the resin extracted from the olibanum was evaluated as coating material in microentrapment.…”

Section: Introductionmentioning

confidence: 99%

Mannequin-Simulator as a New Teaching and Learning Method in Performance-Based Pharmacotherapy

Makmor‐Bakry¹,

Azmi²,

Ali³

2013

IJPER

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Olibanum gum resin was evaluated as rate controlling agent and to prepare resin-coated microspheres. Zidovudine (AZT), an anti-retroviral drug was selected as novel drug for the experiment. Resin coated microspheres of AZT were prepared by spray drying technique using olibanum gum resin as a rate controlling polymer and the microspheres were evaluated. The resin-coated microspheres were spherical, discrete, free flowing and multinucleate monolithic type. The mean size range was found for formulation D: P1, D: P2, D: P3 in the range of 16.88, 18.51, and 21.72 µm respectively. Entrapment efficiency was in the range of 67.41 to 80.32%. The FTIR and DSC study confirmed that no chemical interaction took place during entrapment process. The X-ray diffraction study indicates the amorphous dispersion of the drug after entrapment into microspheres. The effect of polymeric resin on release profile of drug was calculated. AZT release from the resin coated microspheres was slow over 24 hr and dependant on core: coat ratio, and size of microspheres. Drug release was by non-fickian diffusion mechanism. Good linear relationships were observed between core: coat ratio of the microspheres and release rate. Resin-coated microspheres of AZT exhibited good controlled release characteristics and were found suitable for once a day oral controlled release products.Keywords: Olibanum gum resin, spray drying, non-fickian diffusion, controlled release ABSTRACT

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Formulation characterization and in vitro evaluation of acacia gum–calcium alginate beads for oral drug delivery systems

Benfattoum

Haddadine

Bouslah

et al. 2017

Polymers for Advanced Techs

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In the present work, new matrix bead formulations based on linear and branched polysaccharides have been developed using an ionic gelation technique, and their potential use as oral drug carriers has been evaluated. Using calcium chloride as a cross-linking agent and sodium diclofenac (SD), as a model drug, acacia gum-calcium alginate matrix beads were formulated.The response surface methodology based on 3 2 factorial design was used as a statistical method to evaluate and optimize the effects of the biopolymers-blend ratio and the concentration of calcium chloride on the particle size (mm), density (g/cm 3 ), drug encapsulation efficiency (%), and the cumulative drug release after 8 hours (R 8h ,%). The optimized beads with the highest drug encapsulation efficiency were examined for a drug-excipients compatibility by powder X-ray diffraction, differential scanning calorimetry, thermo-gravimetric analysis, and Fourier transforminfrared spectroscopy analyses. The swelling and degradation of the matrix beads were found to be influenced by the pH of medium. Higher degrees of swelling were observed in intestinal pH than in stomach pH. Accordingly, the drug release study showed that the amount of SD released from the acacia gum-calcium alginate beads was higher in intestinal pH than in stomach pH. Therefore, the in vitro drug release from the SD-loaded beads appears to follow the controlledrelease (Hixson-Crowell) pattern involving a case-2 transport mechanism operated by swelling and relaxation of the polymeric blend matrix. KEYWORDS acacia gum-calcium alginate, beads, branched polysaccharide, linear polysaccharide, oral drug delivery 1 | INTRODUCTION Polysaccharides represent a class of natural chemical compounds characterized by repetitive structural units with a wide degree of dispersion. 1 A growing interest in these chemical compounds has resulted in the identification of a number of important biochemical and biomedical applications, not only because of their low cost, biocompatibility, biodegradability, high swelling capability, and stability in various pHs but also because of their potential use in controlled drug delivery systems. 1-4 Different forms of natural polysaccharides such as nanostructures, 5,6 films, 7 tablets, 8,9 and hydrogels 10 have been reported in the literature. Recently, attention has been focused on the development of ionic polysaccharide hydrogel beads for use as oral drug carriers. 11 Different ionic polysaccharide beads based on sodium alginate (SA), 12 chitosan, 13 and pectin 14 have been extensively developed and examined for the encapsulation of a wide range of drugs. 15,16 However, major limitations of these ionic beads are the small drug encapsulation capacity due to drug leaching through the pores and the fast degradation in alkaline pH media resulting in burst release of drugs. 17 To overcome the limitations of these ionic polysaccharide beads, the combination of ionic and natural polysaccharides has been proposed. 18,19 Most of the reported results using this approach are based ...

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Evaluation of olibanum and its resin as rate controlling matrix for controlled release of diclofenac

Cited by 30 publications

References 1 publication

Evaluation of Hydrophilic Polymers and their Combinations in Formulation of Sustained-Release Matrix Tablets of Water-Soluble Drug

Evaluation of Hydrophilic Polymers and their Combinations in Formulation of Sustained-Release Matrix Tablets of Water-Soluble Drug

Mannequin-Simulator as a New Teaching and Learning Method in Performance-Based Pharmacotherapy

Formulation characterization and in vitro evaluation of acacia gum–calcium alginate beads for oral drug delivery systems

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