Evaluation of optic nerve head blood flow in normal rats and a rodent model of non-arteritic ischemic optic neuropathy using laser speckle flowgraphy

Hidaka, Toshikazu; Chuman, Hideki; Nao‐i, Nobuhisa

doi:10.1007/s00417-017-3753-3

Cited by 5 publications

(2 citation statements)

References 24 publications

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“…By determining different parameters of blood flow such as MBR of total area (MA), vessel region (MV), and tissue region (MT) regional differences in blood flow could be found ( 162 ). There have also been reports of parallel studies in different groups providing the possibility to compare blood flow in physiologic and pathological animal models in longtime studies ( 163 ). The monitoring of pharmacological interventions in rats has also been studied using LSFG ( 164 ).…”

Section: Methods Of Measurementmentioning

confidence: 99%

Methods to measure blood flow and vascular reactivity in the retina

Böhm

Pfeiffer²,

Wagner³

et al. 2023

Front. Med.

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Disturbances of retinal perfusion are involved in the onset and maintenance of several ocular diseases, including diabetic retinopathy, glaucoma, and retinal vascular occlusion. Hence, knowledge on ocular vascular anatomy and function is highly relevant for basic research studies and for clinical judgment and treatment. The retinal vasculature is composed of the superficial, intermediate, and deep vascular layer. Detection of changes in blood flow and vascular diameter especially in smaller vessels is essential to understand and to analyze vascular diseases. Several methods to evaluate blood flow regulation in the retina have been described so far, but no gold standard has been established. For highly reliable assessment of retinal blood flow, exact determination of vessel diameter is necessary. Several measurement methods have already been reported in humans. But for further analysis of retinal vascular diseases, studies in laboratory animals, including genetically modified mice, are important. As for mice, the small vessel size is challenging requiring devices with high optic resolution. In this review, we recapitulate different methods for retinal blood flow and vessel diameter measurement. Moreover, studies in humans and in experimental animals are described.

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Section: Methods Of Measurementmentioning

confidence: 99%

Methods to measure blood flow and vascular reactivity in the retina

Böhm

Pfeiffer²,

Wagner³

et al. 2023

Front. Med.

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“…Laser speckle flowgraphy (LSFG) is based on the laser speckle phenomenon and is a noninvasive instrument that can measure two-dimensional relative blood flow velocity of the ocular microcirculation in real time ( 12 , 13 ). The mean blur rate (MBR), which represents the velocity of optic nerve blood flow, has been previously applied to monitor the severity of glaucoma ( 14 , 15 ), evaluate ischemic optic neuropathy ( 16 , 17 ), and detect retinal diseases ( 18 ). Although LSFG can be used to estimate optic nerve blood flow, to the best of our knowledge, it has never been used to monitor blood flow changes in patients with TED or to evaluate the severity of TED.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Microcirculation in Optic Nerve Head Using Laser Speckle Flowgraphy in Active Thyroid Eye Disease

Tsai

Chu

et al. 2022

BioMed Research International

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Background. Laser speckle flowgraphy (LSFG) can be used to estimate optic nerve blood flow. This study used LSFG to evaluate optic nerve microcirculation in patients with thyroid eye disease (TED). Methods. This was a retrospective review of patients with active TED who underwent LSFG between October 2020 and June 2021. The mean blur rate (MBR) for different severities of active TED was analyzed by one-way analysis of variance (ANOVA). Results. A total of 30 patients (60 eyes) with a diagnosis of active TED who underwent LSFG were included. The mean age was 49 (range, 33–74) years. Mean best-corrected visual acuity was the worst in the group with sight-threatening active TED ( 0.29 ± 0.33 logarithm of the minimum angle of resolution, p = 0.01 ). The MBR-overall was the highest in the group with mild active TED ( 28.5 ± 2.7 ), followed by that in the moderate to severe ( 23.6 ± 3.2 ), and in the sight-threatening ( 20.2 ± 4.3 ) active TED groups ( p < 0.001 ). The MBR-vessel was 57.1, 47.0, and 39.3 in the mild, moderate to severe, and sight-threatening active TED groups, respectively ( p < 0.001 ). The MBR-tissue was 16.9, 14.4, and 12.0 in the mild, moderate to severe, and sight-threatening active TED groups, respectively ( p < 0.001 ). Conclusions. This study demonstrates that optic nerve blood flow is lower with more severe active TED. In addition, LSFG is an effective, objective, and noninvasive method for evaluating the severity of TED.

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Effects of ripasudil, a rho kinase inhibitor, on blood flow in the optic nerve head of normal rats

Wada

Higashide

Nagata

et al. 2018

Graefes Arch Clin Exp Ophthalmol

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Evaluation of optic nerve head blood flow in normal rats and a rodent model of non-arteritic ischemic optic neuropathy using laser speckle flowgraphy

Abstract: Our results indicated that the ONH blood flow of the rNAION rats fell in the acute and chronic phases.

Cited by 5 publications

References 24 publications

Methods to measure blood flow and vascular reactivity in the retina

Methods to measure blood flow and vascular reactivity in the retina

Evaluation of Microcirculation in Optic Nerve Head Using Laser Speckle Flowgraphy in Active Thyroid Eye Disease

Effects of ripasudil, a rho kinase inhibitor, on blood flow in the optic nerve head of normal rats

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