Evaluation of organ function in patients with severe COVID-19 infections

Abstract

Objective The purpose of our study was to assess organ function in 102 patients with severe COVID-19 infections, using retrospective clinical analysis. Material and methods A retrospective analysis was conducted on 102 patients with severe COVID-19 infections. The patients were divided into a survival group ( n = 73) and a non-survival group ( n = 29) according to their prognosis. The age, sex, underlying diseases, clinical laboratory data within 48 h (routine blood tests, ALT, AST, TBIL, ALB, BUN, CR, D-Dimer, PT, APTT, FIB, F VIII:C, CK-MB, CK, and LDH), and ventilation status were collected. The organ functions of these severe COVID-19 patients were assessed by comparing the differences between the two groups. Results AST, BUN, CR, CK-MB, LDH, and CK in the non-survival group were higher than those in the survival group, and the differences were statistically significant ( P < 0.05). D-Dimer, PT, FIB, and F VIII:C in the non-survival group were higher than the values observed in the survival group, and the differences were statistically significant ( P < 0.05). PLT, AST, BUN, CR, D-Dimer, PT, FIB, F VIII:C, CK-MB, CK, and LDH predicted the area under the ROC curve (AUC) of the COVID19 endpoint events and were 0.721, 0.854, 0.867, 0.757, 0.699, 0.679, 0.715, 0.811, 0.935, and 0.802, respectively. Conclusion The results showed that there were different degrees of damage to the liver, kidneys, blood coagulation, and heart function in the non-survival group. In addition, PLT, AST, BUN, CR, D-Dimer, PT, FIB, F VIII:C, CK-MB, CK, and LDH had value in evaluating disease prognosis.

Liver injury in the era of COVID-19

“…AST was evaluated in patients with a severe presentation of COVID-19 as a potential diagnostic marker and its level was significantly higher in non-survivors compared with survivors. Receiver operating characteristic (ROC) curve analysis of AST revealed an area under the curve (AUC) of 0.854, indicating the prognostic value of this marker in infected patients[ 57 ].…”

Lactate dehydrogenase and aspartate aminotransferase levels associated with the severity of COVID‑19: A systematic review and meta‑analysis

“…Fifteen studies were conducted in Asia. Eleven of the studies were in China ( 15 , 22 , 23 , 25 , 29 , 30 , 32 , 33 , 35-37 ), one in Japan ( 31 ), one in India ( 19 ), one in Iran ( 28 ), and one in Pakistan ( 24 ); four studies were conducted in Europe, one in Georgia ( 21 ), one in Belgium ( 17 ), one in the Italian ( 18 ), one in Spain ( 34 ); two studies were performed in the Eurasian country of Turkey ( 16 , 26 ); one study was performed in African Morocco ( 27 ); one study was performed in North America Mexico ( 20 ). All studies were retrospective observation studies, except one was the case-control study ( 15 ).…”

Cardiovascular Disease Complicating COVID-19 in the Elderly

“…In COVID-19, LDH may be released from the lung since this is a key site for inflammatory processes [ 150 ]. LDH levels above 445 μg/mL on admission can be predictive of more severe COVID-19 [ 133 , 151 , 152 , 153 ]. An analysis of 353 COVID-19 patients, 79 (22.4%) of whom presented with myocardial injury, revealed more frequent elevations in LDH (mean level: 244 U/L (without MI) vs. 655 U/L (with MI) and creatinine (71 μmol/L (without MI) vs. 155 μmol/L (with MI) in the MI group during their hospitalization [ 154 ].…”