Evaluation of Osteoconduction of a Synthetic Hydroxyapatite/β-Tricalcium Phosphate Block Fixed in Rabbit Mandibles

Abstract

(1) Background: This study aimed to evaluate the incorporation of hydroxyapatite/β-tricalcium phosphate blocks grafted in rabbit mandibles. (2) Methods: Topographic characterization of biomaterial was performed through scanning electron microscopy coupled with energy-dispersive X-ray spectroscopy (SEM-EDX). Ten rabbits randomly received autogenous bone graft harvested from the tibia (Autogenous Group—AG) or synthetic biomaterial manufactured in β-tricalcium phosphate (Biomaterial Group—BG) at their right and left mandibular angles. Euthanasia was performed at 30 and 60 postoperative days; (3) Results: SEM-EDX showed a surface with the formation of crystals clusters. Histological analyses in BG at 30 days showed a slower process of incorporation than AG. At 60 days, BG showed remnants of biomaterial enveloped by bone tissue in the anabolic modeling phase. Histometric analysis showed that mean values of newly formed bone-like tissue in the AG (6.56%/9.70%) were statistically higher compared to BG (3.14%/6.43%) in both periods, respectively. Immunohistochemical analysis demonstrated early bone formation and maturation in the AG with more intense osteopontin and osteocalcin staining. (4) Conclusions: The biomaterial proved to be a possible bone substitute, being incorporated into the receiving bed; however, it showed delayed bone incorporation compared to autogenous bone.

Combination of anthocyanin ternatin and hydroxyapatite/β-tricalcium phosphate coralline as a socket preservation biomaterial in dental implant: A narrative review

“…The decreased volume of bone will form a rounded and flat structure which will reduce the retention and stability of fixed dentures, removable dentures, and dental implants. [2,13]In general, tooth sockets will undergo a process of physiological healing of hard tissue and soft tissue, however, defects in the alveolar bone cannot regenerate completely, so treatment is needed to restore the condition of the alveolar bone. [13] Nowadays, researchers are developing preservation treatments to restore the alveolar bone anatomy.…”

“…[2,13]In general, tooth sockets will undergo a process of physiological healing of hard tissue and soft tissue, however, defects in the alveolar bone cannot regenerate completely, so treatment is needed to restore the condition of the alveolar bone. [13] Nowadays, researchers are developing preservation treatments to restore the alveolar bone anatomy. Socket preservation is a procedure in which a graft material is placed in a post-extraction tooth socket with or without a membrane barrier to maintain or increase ridge dimensions for an ideal implant site.…”

Cell-Based Tissue Engineering for Guided Bone Regeneration in Rats: A Preliminary Study with 3D-Printed β-Tricalcium Phosphate Scaffolds and Polydioxanone Membranes

“…β-tricalcium phosphate (β-TCP) has been an attractive alternative for bone substitutes due to its excellent bioactive, incorporating, osteoconductive, and resorbable capacity when used in bone grafting [16][17][18][19]. The scienti c interest in β-TCP use for alveolar/maxillofacial region is based on its formulation that enables the creation of scaffolds, which liberate calcium ions when reabsorbed [18].…”

Performance of Polydioxanone-Based Membrane in Association with 3D-Printed Bioceramic Scaffolds in Bone Regeneration

“…Bioactive ceramics from alloplastic material are entirely synthesized from nonorganic sources [ 12 ], including β-tricalcium phosphate (β-TCP) and hydroxyapatite (HA) ceramics [ 13 ]. β-TCP has been an attractive alternative for bone substitutes due to its excellent bioactive, incorporating, osteoconductive and resorbable capacity when used in bone grafting [ 14 , 15 , 16 , 17 ]. The scientific interest in β-TCP use for alveolar/maxillofacial regions is based on its formulation that enables the creation of scaffolds, which liberate calcium ions when reabsorbed [ 16 ].…”