Evaluation of osteogenic potential of Cissus quadrangularis on mandibular alveolar ridge distraction

Abstract

Background This randomized clinical trial was designed to evaluate osteogenic potential of Cissus quadrangularis in alveolar distraction to facilitate implant installation. Material and methods Twenty patients with atrophic ridge were treated by alveolar distraction. After completing distractor activation, patients were randomly divided into two equal groups according to administered drug (placebo and Cissus quadrangularis group). After a consolidation period, distractors were removed and implants were inserted. Clinical evaluation was done to assess wound healing, and distractor and implant stability. Histological evaluation was performed at time of implant insertion. Radiographic evaluation was performed to assess bone volume and density after distraction, as well as, density and bone loss around implant. Results Radiographic and histological results showed that bone formation and maturation of study group were faster than that of control group. There was a significant increased bone density in distracted area and around implant in study group than control group. A significant bone loss at end of consolidation period, and around implant at end of the study was reported in control group than study group. Conclusion Cissus quadrangularis administration during the consolidation period is associated with increased osteogenic potential of distracted bone. The histological and radiographic findings of current study proved that Cissus quadrangularis not only enhances rate of new bone formation, but also bone density to withstand the biomechanical requirements of implant placement in a shorter time. Trial registration This study was retrospectively registered on www.ClinicalTrial.gov: NCT04669795-17\12\2020.

Biocompatibility and antioxidant activity of a novel carrageenan based injectable hydrogel scaffold incorporated with Cissus quadrangularis: an in vitro study

“…To the best of our knowledge, the latter has not been explored for its therapeutic potential; however, its potential for osteogenesis has been extensively studied. The osteogenesis potential of Cissus quadrangularis extract has been explored in various dental clinical situations such as periodontal bone regeneration [ 34 ], mandibular alveolar ridge distractions [ 35 ] and in maxillofacial [ 36 ] and mandibular fractures [ 37 ]. In particular, the Cissus quadrangularis extracts have been shown to contain calcium, along with other compounds [ 38 ] and thus probably have shown to regulate osteoblastic activity [ 39 ] by enhancing osteoblastogenesis [ 39 ], mineralization [ 40 ] and eventually induce bone formation for faster bone healing [ 41 ].…”

Role of Cissus quadrangularis in bone loss pathologies

“…Also, a significant increase in bone density around implant and in distracted area was observed in CQ group. CQ, thus not only enhanced the rate of new bone formation, but also bone density to withstand the biomechanical requirements of implant placement in a shorter time [31] . Multiple case studies have also been published in various fracture conditions to evaluate the effect of CQ on fracture healing.…”

Exploring the Potential of Phytogenic Materials for Bone Regeneration: A Narrative Review of Current Advances and Future Directions

“…Cissus quadrangularis , recognized for its bone regeneration potential, was systemically administered in a study by Altaweel et al The results underscored its ability to speed up mandibular bone formation and boost bone density, suggesting its potential application as a graft material or in combination with other graft materials [ 33 ]. All studies and investigations have been consolidated in Table 1 .…”