Evaluation of oxidant and intracellular anti-oxidant activity in rheumatoid arthritis patients: In vivo and in silico studies

Ogul, Yasemin; Gür, Fatma; Cengiz, Mustafa; Gür, Bahri; Sari, Refik Ali; Kızıltunç, Ahmet

doi:10.1016/j.intimp.2021.107654

Cited by 18 publications

(6 citation statements)

References 37 publications

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“…All the researchers except one who studied these enzymatic endogenous antioxidant markers selected in this review reported significant reduction of GPx, SOD and Catalase in rheumatoid arthritis patients than normal human volunteers. Ogul Y et al 30 in his studies reported non-significant decrease in catalase level in Rheumatoid arthritis group than that of the control group composed of normal human volunteers.…”

Section: Enzymatic Endogenous Antioxidantsmentioning

confidence: 89%

A Systematic Review on Association of Oxidative Stress in Rheumatoid Arthritis Based on Cross-Sectional Case-Control Studies

Ahmed,

Chetia,

Kalita

2024

Ind. J. Pharm. Edu. Res

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Section: Enzymatic Endogenous Antioxidantsmentioning

confidence: 89%

A Systematic Review on Association of Oxidative Stress in Rheumatoid Arthritis Based on Cross-Sectional Case-Control Studies

Ahmed,

Chetia,

Kalita

2024

Ind. J. Pharm. Edu. Res

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“…In RA patients, joint synovial cells and chondrocytes may produce excessive free radicals, resulting in tissue destruction and inflammation. An observational study conducted by Ogul et al [49] suggested that malondialdehyde, a strong marker of free oxygen radicals, was notably elevated in RA patients. Khojah H. M. et al [50] found that reactive oxygen species (including superoxide anion, hydroxyl radical, hydrogen peroxide, and peroxyl radical) and reactive nitrogen (including nitric oxide and peroxynitrites) levels of RA patients were significantly higher than those in the control group.…”

Section: Discussionmentioning

confidence: 99%

Association between oxidative balance score and rheumatoid arthritis in female: a cross-sectional study

La,

Zhou,

Yin

et al. 2024

BMC Women's Health

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Objective Although oxidative stress is a recognized factor of inflammation, the correlation between oxidative balance score (OBS), a biomarker indicating the balance of oxidation and antioxidant, and rheumatoid arthritis (RA), an immune system disease that tends to occur in women, remains unexplored. Hence, the aim of this study was to investigate the potential association between OBS and RA in women. Methods Observational surveys were performed by employing information extracted from the National Health and Nutrition Examination Survey (NHANES) for the period 2007–2018. Various statistical techniques were employed to investigate the association between OBS and RA, encompassing multivariable logistic regression analysis, subgroup analyses, smooth curve fitting, and threshold effect analysis. Results The study included 8219 female participants, including 597 patients with RA. The results showed that higher Total OBS (TOBS) significantly correlated with lower RA prevalence in the entirely modified model [odd ratio (OR) = 0.968; 95% confidence interval (CI) = 0.952 to 0.984; P = 0.0001]. Dietary OBS (DOBS) and lifestyle OBS (LOBS) also negatively correlated with RA. This association was remarkably consistent across TOBS subgroups by age, race, education level, family poverty-to-income ratio (PIR), hypertension and diabetes. Smooth curve fitting and threshold effect analysis also revealed the linear relationship between OBS and RA. Conclusions Overall, OBS was negatively associated with RA in female. This study suggested that an antioxidant diet and lifestyle may be promising measures to prevent RA in female.

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“…MDA along with the inflammatory marker CRP was also significantly raised, hence, validating the OS state. 14 RA and AS presentation is a picture of prolonged underlying inflammation. OS over a long period of time, particularly in the synovium of RA patients, has been held responsible for bringing about an increase in intra-articular pressure, subsequently leading to augmented production of ROS as a by-product of the electron transport chain and oxidative phosphorylation occurring in the mitochondria.…”

Section: Discussionmentioning

confidence: 99%

Comparison of oxidative stress, lipid peroxidation and inflammatory markers between rheumatoid arthritis and ankylosing spondylitis patients

Sumbal Khan,

Dr M Javad Yousaf,

Dr Amir Rashid

et al. 2024

J Pak Med Assoc

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Objective: To measure the levels of superoxide dismutase and malondialdehyde along with erythrocyte sedimentation rate and C-reactive protein in patients of rheumatoid arthritis and ankylosing spondylitis. Method: The comparative, cross-sectional study was conducted from February 2 to December 30, 2022, at the Centre for Research in Experimental and Applied Medicine laboratory of the Department of Biochemistry and Molecular Biology, Army Medical College, Rawalpindi, Pakistan, in collaboration with the Department of Rheumatology, Pak Emirates Military Hospital, Rawalpindi. The sample comprised healthy controls in group 1, patients of rheumatoid arthritis in group 2 and patients of ankylosing spondylitis in group 3. Blood samples were assessed for levels of superoxide dismutase, malondialdehyde, erythrocyte sedimentation rate and C-reactive protein. Data was analysed using SPSS 25. Results: Of the 180 subjects, 60(33.3%) were in group 1; 32(53.3%) females and 28(46.7%) males with mean age 34.9±6.4 years. There were 60(33.3%) patients in group 2; 35(58.3%) females and 25(41.7%) males with mean age 46.0±11.1 years. There were 60(33.3%) patients in group 3, and all 60(100%) were males with mean age 35.9±6.9 years. Superoxide dismutase level was significantly low and malondialdehyde level was significantly high in groups 2 and 3 compared to group 1 (p<0.05). Erythrocyte sedimentation rate was the highest in group 2, followed by group 3 (p<0.05). C-reactive protein levels were the highest in group 2 and the lowest in group 3 (p<0.05). A significantly negative correlation (p<0.001) was found between superoxide dismutase and malondialdehyde. Conclusion: Oxidative stress played a pivotal role in chronic inflammatory rheumatic diseases, like rheumatoid arthritis and ankylosing spondylitis. Key Words: Rheumatoid arthritis, Ankylosing spondylitis, Superoxide dismutase, Malondialdehyde.

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Evaluation of oxidant and intracellular anti-oxidant activity in rheumatoid arthritis patients: In vivo and in silico studies

Cited by 18 publications

References 37 publications

A Systematic Review on Association of Oxidative Stress in Rheumatoid Arthritis Based on Cross-Sectional Case-Control Studies

A Systematic Review on Association of Oxidative Stress in Rheumatoid Arthritis Based on Cross-Sectional Case-Control Studies

Association between oxidative balance score and rheumatoid arthritis in female: a cross-sectional study

Comparison of oxidative stress, lipid peroxidation and inflammatory markers between rheumatoid arthritis and ankylosing spondylitis patients

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