Evaluation of oxidative metabolism and oxidative <scp>DNA</scp> damage in patients with obsessive–compulsive disorder

Alici, Demet; Bülbül, Feridun; Virit, Osman; Ünal, Ahmet; Altındağ, Abdurrahman; Alpak, Gökay; Alıcı, Hayri; Ermis, Berna; Örkmez, Mustafa; Taysı, Seyithan; Savaş, Haluk A.

doi:10.1111/pcn.12362

Cited by 37 publications

(19 citation statements)

References 28 publications

(75 reference statements)

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“…From full‐text review of the resulting 31 papers, 14 did not meet inclusion criteria and 17 were included in our qualitative synthesis. Four of these were ineligible for quantitative synthesis, resulting in 13 studies considered for quantitative analysis . Two of these studies assessed the same sample, but data from both were included since they provided complementary information (i.e., distinct markers and correlation between TBARS and Y‐BOCS) .…”

Section: Resultsmentioning

confidence: 99%

“…Growing evidence supports the possibility that psychiatric disorders may be considered multisystem disorders, with patients presenting altered immune and oxidative markers, when compared to healthy controls . Specifically for OCD, while its exact etiology and pathophysiology remain unknown, systemic dysregulation of inflammation and oxidative stress has been increasingly reported . Regarding inflammation, recent meta‐analyses have confirmed that patients with OCD have reduced plasma IL‐1β and increased anti‐basal ganglia antibodies, in comparison with healthy controls .…”

Section: Introductionmentioning

confidence: 99%

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Oxidative and nitrosative stress markers in obsessive–compulsive disorder: a systematic review and meta‐analysis

Maia

Oliveira

Lajnef

et al. 2019

Acta Psychiatr Scand

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Oxidative and nitrosative stress markers in obsessive-compulsive disorder: a systematic review and meta-analysis Maia A, Oliveira J, Lajnef M, Mallet L, Tamouza R, Leboyer M, Oliveira-Maia AJ. Oxidative and nitrosative stress markers in obsessive-compulsive disorder: a systematic review and meta-analysis Objective: Obsessive-compulsive disorder (OCD) is a chronic, prevalent, and highly impairing psychiatric illness. Although the pathophysiology of OCD remains unknown, pathways involved in oxidative and nitrosative stress (O&NS) have been implicated. The present study aims to systematically review the literature for quantitative evidence that patients with OCD have altered measures of blood O&NS markers. Methods: Independent random-effects meta-analyses using standardized mean differences were conducted to assess each marker separately. Additionally, data from multiple markers were pooled together in a metaanalysis for measures of oxidant activity and another for measures of antioxidant activity. Results: Thirteen studies met inclusion criteria, involving 433 OCD patients and 459 controls. Eleven blood O&NS markers were eligible for independent quantitative analyses. We found that, in OCD patients, the oxidant markers 8-hydroxydeoxyguanosine and malondialdehyde, and the antioxidants glutathione peroxidase and superoxide dismutase, were significantly increased while total antioxidant status, vitamin C, and vitamin E were significantly decreased, when comparing with controls. Regarding pooled meta-analyses, we found a statistically significant increase in oxidant markers, but non-significant results regarding antioxidant markers. Conclusions: Our meta-analysis suggests that OCD patients have a systemic oxidative imbalance that is not adequately buffered by the antioxidant system. Additional studies are needed in order to support this association. Summations• Patients with obsessive-compulsive disorder have a dysregulated oxidative profile with increased blood oxidative markers.• No global changes in antioxidant defenses in obsessive-compulsive disorder are of remark thus suggesting that oxidative stress is not adequately buffered.• Our results underline the systemic impact of obsessive-compulsive disorder and should motivate the development of future studies in order to better understand this association. Considerations• Most studies did not provide measurements of oxidative and nitrosative stress markers according to pertinent demographic and clinical characteristics thus impairing relevant sensitivity analyses that would have allowed to assess the potential impact of these factors in the results.• The limited number of studies, their moderate quality and heterogeneity, and the evidence for publication bias prevent more robust conclusions.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Oxidative and nitrosative stress markers in obsessive–compulsive disorder: a systematic review and meta‐analysis

Maia

Oliveira

Lajnef

et al. 2019

Acta Psychiatr Scand

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“…Experimental studies have consistently provided support for a deficient glutathione oxidative protective system in the animal model of OCD, especially in the frontal cortex . The beneficial effect of minocycline in OCD patients is partly due to its anti‐oxidative characteristics, as oxidative stress is known to be associated with OCD …”

Section: Discussionmentioning

confidence: 99%

Minocycline combination therapy with fluvoxamine in moderate‐to‐severe obsessive–compulsive disorder: A placebo‐controlled, double‐blind, randomized trial

Esalatmanesh

Abrishami

Zeinoddini

et al. 2016

Psychiatry Clin Neurosci

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“…[ 6 , 7 ] Oxidative stress and reduced antioxidant status are common to many psychiatric disorders inclusive of schizophrenia, depression, bipolar, and obsessive-compulsive disorders. [ 1 , 8 ] Increasing production of glutathione assists in the restoration of redox imbalance in these conditions.…”

Section: Mechanisms Of Actionmentioning

confidence: 99%

N-Acetylcysteine for the Treatment of Psychiatric Disorders: A Review of Current Evidence

Ooi¹,

Green

Pak

2018

BioMed Research International

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N-acetylcysteine, a sulphur-containing amino acid for the treatment of paracetamol overdose and chronic obstructive pulmonary disease, is a widely available off-the-shelf oral antioxidant supplement in many countries. With the potential to modulate several neurological pathways, including glutamate dysregulation, oxidative stress, and inflammation that can be beneficial to the brain functions, N-acetylcysteine is being explored as an adjunctive therapy for many psychiatric conditions. This narrative review synthesises and presents the current evidence from systematic reviews, meta-analyses, and latest clinical trials on N-acetylcysteine for addiction and substance abuse, schizophrenia, obsessive-compulsive and related disorders, and mood disorders. Good evidence exists to support the use of N-acetylcysteine as an adjunct treatment to reduce the total and negative symptoms of schizophrenia. N-acetylcysteine also appears to be effective in reducing craving in substance use disorders, especially for the treatment of cocaine and cannabis use among young people, in addition to preventing relapse in already abstinent individuals. Effects of N-acetylcysteine on obsessive-compulsive and related disorders, as well as on mood disorders, remain unclear with mixed reviews, even though promising evidence does exist. Larger and better-designed studies are required to further investigate the clinical effectiveness of N-acetylcysteine in these areas. Oral N-acetylcysteine is safe and well tolerated without any considerable adverse effects. Current evidence supports its use as an adjunctive therapy clinically for psychiatric conditions, administered concomitantly with existing medications, with a recommended dosage between 2000 and 2400 mg/day.

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Evaluation of oxidative metabolism and oxidative DNA damage in patients with obsessive–compulsive disorder

Cited by 37 publications

References 28 publications

Oxidative and nitrosative stress markers in obsessive–compulsive disorder: a systematic review and meta‐analysis

Oxidative and nitrosative stress markers in obsessive–compulsive disorder: a systematic review and meta‐analysis

Minocycline combination therapy with fluvoxamine in moderate‐to‐severe obsessive–compulsive disorder: A placebo‐controlled, double‐blind, randomized trial

N-Acetylcysteine for the Treatment of Psychiatric Disorders: A Review of Current Evidence

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