Evaluation of Oxidative Stress and LeptinLevel in Samples of Iraqi Obese Women

Ali, Israa; Yenzeel, Jabbar H.; Al-ansari, Hani M. Saleh

doi:10.24996/ijs.2020.61.7.3

Cited by 11 publications

(11 citation statements)

References 21 publications

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“…In medicine, obesity is known as a state of accumulation of fatty bodies in the body, which leads to an increase in cases of diseases, leading to death, especially in people who suffer from obesity (10) As for rheumatoid arthritis, it is an auto-immune disorder that infect women more than men, especially in the old age (11). Our study evaluated body measurements, including (WHR and BMI), which showed a severe increase in obese women and obese women with RA in comparison to control women and this finding agrees with results of a previous study (12). The BMI has a positive correlation to BF% and thus the BMI increases with increase of BF%.…”

Section: Discussionsupporting

confidence: 92%

Study of some physiological and hematological parameters in obese women with arthritis

Jabbar¹,

Hussain²

2023

Biomedicine

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Introduction and Aim: Obesity and overweight refers to excessive buildup of fat in the body. Arthritis is a group of medical disorders associated with obesity and being overweight. Obesity associated with rheumatoid arthritis is more pronounced in women. In this study, we aimed to evaluate some physiological and hematological parameters in obese women with arthritis. Materials and Methods: This study included 90 women aged between 18 and 68 years. The women were divided into three groups based on their BMI as Obese (n=30), Obese+RA (n=30) and normal lean women as controls (n=30). Blood drawn from each participant was tested for their complete blood tests, lipid profiles, C-reactive protein reaction and presence of rheumatoid factor. Data was subjected to statistical analysis. Results: Our study revealed the mean +SE for age, WHR and BMI to be elevated in women in the obese as well as Obese+RA groups and to be significantly higher in comparison to women in the control group. Except for HDL, all the other lipid parameters were seen elevated in the obese and Obese+RA group and showed significant difference from the control group. Similarly, among the complete blood count indices only ESR, WBC and PLT were found to be significantly elevated in obese and Obese+RA groups. The prevalence percentage for CRP and RF was seen to be highest in individuals belonging to the Obese+RA group. Conclusion: Obese women as well as obese women with RA have elevated hematological and physiological parameters when compared to lean women.

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Section: Discussionsupporting

confidence: 92%

Study of some physiological and hematological parameters in obese women with arthritis

Jabbar¹,

Hussain²

2023

Biomedicine

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“…The estrogen hormone showed highly significant difference (P≤0.01) among G1 (55.74 ± 9.23) and G2 (55. 35 ------------------------------------------------------------------------------------------------------------------------------------------In this study the age, BMI and WHR in obese and obese RA women showed highly significant difference compared to control and this finding agrees with another study (20) .…”

Section: Estrogen Hormonesupporting

confidence: 93%

Estimation of Leptin and Estrogen Hormones in Obese Women with Arthritis

Jabbar¹,

Hussein²

2023

The Egyptian Journal of Hospital Medicine

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Background: Obesity is abnormal accumulation of fat in the body, which led to many health problems that will reduce the life expectancy. Arthritis is joints inflammation that cause many of symptoms such as swelling, tenderness, pain and stiffness of most joints. The arthritis is divided into many types, but the most common types are osteoarthritis and rheumatoid arthritis the last type is the focus of our topic. Rheumatoid arthritis (RA) is an auto-immune, chronic inflammation that can cause damage for joints and other body organs like skin, eyes, lungs, heart and blood vessels.Objective: The study aimed to investigate the levels of leptin and estrogen hormones in obese women with arthritis. We focused on rheumatoid arthritis especially. Patients and Methods: The research included ninety women They were distributed into three groups, 30 obese women with body mass index (BMI) more than 25 Kg/m 2 for overweight and more than 30 Kg/m 2 for obese, 30 obese women with rheumatoid arthritis which have positive rheumatoid factor (RF) and 30 control women with normal weight and BMI < 25Kg/m 2 and healthy from RA. BMI, WHR was calculated for all participants. Result: The result of estrogen hormone showed highly significant difference (P≤0.01) in G1 (55. 74 ± 9.23), G2 (55.35 ± 11.77) compared to G3 (129.85 ±16.69). While leptin hormone revealed no significant difference among G1 (2102.13 ±78.03), G2 (2005.80 ±23.81) and G3 (1931.27 ±22.91). Conclusion:We concluded that leptin levels did not differ among the three groups. Conversely estrogen levels showed highly difference between the three groups.

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“…on MDA levels of 4.34 and 1.88 μ mol / L for thalassemia and control respectively with a high moral difference between the two. The MDA rates for both thalassemia and control groups were 2.807 and 1.009 nmol / ml, respectively [26]. This was acceptable to [32] with levels of 1.211 and 1.615 μmol / L in male patients with thalassemia and control respectively, 0.84 and 1.846 μmol / L in female thalassemia patients and control Respectively.…”

Section: Discussionmentioning

confidence: 75%

Effect of sex class on the levels of some biochemical variables in thalassemia patients

Mohammed¹,

Marbut²

2019

Tikrit J. Pure Sci.

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The study was conducted at Azadi Teaching Hospital - Thalassemia Center for the period from 1/10/2017 to 1/4/2018. It included 60 patients including 30 males and 30 females, as well as control group which included 20 Healthy people were all 10 to 21 years of age. The following variables were studied: ferritin, GSH, insulin-like growth factor-1 (IGF-1) Malondialdehyde (MDA) Interleukin-6 (IL-6), and Cortisol. The analysis of correlation coefficients and simple linear regression was carried out to determine the effect of the variables among them. The results were as follows: Thalassemia patients recorded the lowest levels of GSH, IGF-1 and cortisol at 2.2 μmol / L and 50.4 ng / ml and 10.11 μg / dL respectively, while the same group recorded the highest levels of ferritin, MDA and IL- 6 was 3083 ng / ml, 941 mmol / L and 368 pg / mol. There were significant effects of both sexes in the group of thalassemia patients in both ferritin, GSH, IGF-1, MDA, and IL-6 with 2573, 3592 μg / dL, 2.821, 1.573 μmol / L, 63.3, 37.47 ng / ml and 1163.1 719.3 mmol / L 300.9 and 435.6 pg / mol for males and females, respectively. The results of the correlation coefficient analysis showed existence of and low correlations in the negative and positive direction between the study variables of the two groups of patients and control. The results of the simple linear regression analysis showed positive and negative regression ratios of IL-6 and IGF-1 growth factor on the rest of the study variables.

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Evaluation of Oxidative Stress and LeptinLevel in Samples of Iraqi Obese Women

Cited by 11 publications

References 21 publications

Study of some physiological and hematological parameters in obese women with arthritis

Study of some physiological and hematological parameters in obese women with arthritis

Estimation of Leptin and Estrogen Hormones in Obese Women with Arthritis

Effect of sex class on the levels of some biochemical variables in thalassemia patients

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