The aim of this study is to investigate oxidative stress and leptinlevel in obese women. Fifty obese women with BMI value of ≥ 30.0 kg/m2 and thirty healthy women with BMI<24.9 kg/m2 were involved in the study during their attendance at Gastroenterology and Liver Hospital/ Medical city in Baghdad province from October 2018 to February 2019. The age range for all women was 30-50 years. Blood samples were collected from each participant for the evaluation of the levels of leptin hormone, Super Oxide Dismutase (SOD), and Malondialdehyde (MDA). The results of BMI, leptin hormone, MDA and SOD showed highly significant increase (P<0.01) in obese women in comparison with the control group. Results: The results show that BMI value were significantly higher (P<0.01) in obese women (41.90 ± 0.87kg/m2)  in comparison with the control (23.58 ± 0.28kg/m2). The level of leptin hormone was significantly higher(P<0.01) in obese women (1444.00 ± 10.67pg/ml) in comparison with the control (932.26 ± 25.92pg/ml). Also, MDA level was significantly higher(P<0.01) in obese women (6.81 ± 0.29mg/dl) in comparison with the control (4.53 ± 0.44) mg/dl. The level of SOD was significantly higher(P<0.01) in obese women (15.67 ± 1.42mg/dl) in comparison with the control group (3.75 ± 0.60mg/dl). Conclusions: Obesity is detected by the level of leptin Hormone; leptin is regarded as a good parameter for monitoring obesity,showing a high increasewith increasing BMI.Theincrease in obesity causes oxidant stress and formation of MDA that is considered as a major risk factor in obesity,where adecrease in antioxidants was also recorded.

The present study investigates the utilization of the waterworks sludge by-product that generated from water supply treatment plant for the remediation of simulated groundwater contaminated with leachate spilled from the sanitary landfill by permeable reactive barrier (PRB) technology. Batch sorption experiments were conducted for describing the interaction between the acetogenic phase (pH = 5.5 ± 0.1) of leachate contaminated with cadmium (Cd(II)), ammonia nitrogen (NH 3 -N) or dissolved organic matter (COD) and waterworks sludge. Also, conventional sorbents such as the activated carbon and amberlite ion-exchange resin were tested to evaluate their ability in comparison with waterworks sludge in the remediation process. Results proved that the Langmuir model describes well the sorption data with maximum sorption capacities of 5.634, 14.908 and 3.938 mg/g for Cd(II) onto sludge, NH 3 -N onto resin and COD onto activated carbon, respectively. The batch and column tests signified that the sludge, resin, and carbon can be used for removing Cd(II), NH 3 -N, and COD, respectively. The multi-layered bed of sorbents under consideration has a remarkable ability in the remediation of a leachate contaminated with Cd(II), NH 3 -N, and COD. Finally, the Yan model is more representative than Thomas and Belter models for characterization of the contaminants propagation in the column packed with single sorbent.

Silver nanoparticles (AgNPs) is the most important nano molecules that have many medical, industrial, and cosmetic application. We study the effect of these particles on the most vital organs such as the liver and spleen in Wister rats. AgNPs are characterized by using a scanning probe microscope device (SPM). Twenty females were divided into two groups, the control, and the treated group. All treated female's gavage 20mg/ml of AgNPs suspension orally for 29 days. The weight of females was 130±5 g. The liver and spleen were used in this study after staining by H&E. The result showed few intracytoplasmic fat vacuoles on liver tissue, on the other hand, the result displayed brown pigment in the sinusoids. The result showed found marked vascular congestion in liver tissue after being treated with AgNPs compared to the control group. The histological examination of the spleen in treated rats showed the presence of brown pigment in the red pulp of the spleen and congestion, and hemorrhage in treated rats. The result showed brown pigments deposited mainly in red pulp compared to the control group. The result presented that this nanoparticle could penetrate the membranes and reaches into many body organs because can penetrate the brain barrier, bloodstream, and many barriers to the harmful effect of acute exposure or chronic exposure to these nanoparticles.

Introduction Struma Ovarii (SO) is one of the types of mature teratoma accounting for up to 3% of all ovarian tumors, with predominant thyroid tissue (&gt;50%). Most cases are reported in middle-aged women. We are presenting a case of asymptomatic papillary thyroid cancer (PTC) presented in SO that was incidentally found and treated successfully Case presentation A 72-year-old Hispanic female with a history of hysterectomy, tobacco smoking was found to have a suspicious lung nodule on screening with CT scan of Chest. A subsequent PET/CT Scan revealed incidental findings of left adnexal lesion of 12×12 cm with no FDG uptake and had a minimal uptake in lung nodule favoring a hamartoma. At the gynecology clinic, patient denied having vaginal bleeding, bowel dysfunction, abdominal pain or weight loss. She did report urinary incontinence. Pelvic exam demonstrated a mobile left adnexal mass without tenderness. MRI of Pelvis revealed a 15 cm multi-cystic, left ovarian mass compressing the urinary bladder without any lymphadenopathy. Tumor markers of CEA and CA-125 were normal. The patient underwent bilateral salpingo-oophorectomy with extensive adhesolysis. Entire ovarian mass was removed intact. Surgical Pathology revealed a 1.2 cm Unifocal PTC arising in 3 cm SO associated with mucinous cystadenoma without lympho-vascular invasion and extra-ovarian extension. No malignant cells were identified in peritoneal washing. This was staged according to AJCC 8th edition as pT1aNxMna. Immunostaining of TTF-1 and TG were positive, which additionally supported above diagnosis. Mutational testing of BRAF, K-RAS and N-RAS were negative. Post-operatively, at the Endocrine clinic, her TSH and Free T4 were normal. No nodules were detected on the thyroid ultrasound. She was deemed low risk for recurrence and no further treatment was advised except serial monitoring of Thyroglobulin levels and goal TSH &lt; 2.5 mIU/L. Discussion In general, SO can be diagnosed only on a histopathological specimen and no specific radiological or biomarkers are available. Most patients are euthyroid and remain asymptomatic like our patient. Thyrotoxicosis occurs in only 5–15% of patients. SO is mostly benign. Its malignant transformation occurs in only 5% of all cases. The most widespread malignant forms of SO are papillary and follicular carcinomas. There are no well-established guidelines for optimal management of malignant SO. After undergoing oophorectomy, the decision to perform a prophylactic thyroidectomy and administration of 131I-Radioiodine is typically reserved for presence of metastatic disease or high risk of recurrence (&gt;4 cm tumor size, gross extra-ovarian extension, BRAF positivity or histology other than papillary type). Presentation: Sunday, June 12, 2022 12:30 p.m. - 2:30 p.m.

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