Evaluation of oxidative stress and antioxidant status of pregnant women suffering from malaria in Cameroon

Ifoue, Serge Herve Tiyong; Mofor, Clautilde Teugwa; Gouado, Inocent; Této, Georges; Asonganyi, Tazoacha; Zollo, Paul Henri Amvam

doi:10.1007/s12291-009-0054-6

Cited by 20 publications

(33 citation statements)

References 32 publications

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“…falciparum infection might cause oxidative stress in placenta tissue. These observations corroborate previous findings where associations between peripheral plasma levels of MDA and cerebral malaria in children [ 14 ] as well as malaria infection during pregnancy in women have been reported [ 10 ]…”

Section: Discussionsupporting

confidence: 92%

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Impact of Placental Plasmodium falciparum Malaria on the Profile of Some Oxidative Stress Biomarkers in Women Living in Yaoundé, Cameroon

et al. 2015

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BackgroundImpact of the pathophysiology of Plasmodium falciparum placental malaria (PM) on the profile of some oxidative stress biomarkers and their relationship with poor pregnancy outcomes in women remain unknown.MethodsBetween 2013 and 2014, peripheral blood and placenta tissue from 120 Cameroonian women at delivery were assessed for maternal haemoglobin and, parasitaemia respectively. Parasite accumulation in the placenta was investigated histologically. The levels of oxidative stress biomarkers Malondialdehyde (MDA), Nitric Oxide (NO), Superoxide dismutase (SOD), Catalase (CAT) and Gluthatione (GSH) in the supernatant of teased placenta tissues were determined by Colorimetric enzymatic assays.ResultsParasitaemia was inversely related to haemoglobin levels and birth weight (P <0.001 and 0.012, respectively). The level of lipid peroxide product (MDA) was significantly higher in the malaria infected (P = 0.0047) and anaemic (P = 0.024) women compared to their non-infected and non-anaemic counterparts, respectively. A similar trend was observed with SOD levels, though not significant. The levels of MDA also correlated positively with parasitaemia (P = 0.0024) but negatively with haemoglobin levels (P = 0.002). There was no association between parasitaemia, haemoglobin level and the other oxidative stress biomarkers. From histological studies, levels of MDA associated positively and significantly with placenta malaria infection and the presence of malaria pigments. The levels of SOD, NO and CAT increased with decreasing leukocyte accumulation in the intervillous space. Baby birth weight increased significantly with SOD and CAT levels, but decreased with levels of GSH.ConclusionsPlacental P. falciparum infection may cause oxidative stress of the placenta tissue with MDA as a potential biomarker of PM, which alongside GSH could lead to poor pregnancy outcomes (anaemia and low birth weight). This finding contributes to the understanding of the pathophysiology of P. falciparum placental malaria in women.

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Section: Discussionsupporting

confidence: 92%

“…However, Tiyong Ifoue et al . [ 10 ] reported an imbalance between oxidants and antioxidants with regards to malaria in women during pregnancy.…”

Section: Introductionmentioning

confidence: 99%

Impact of Placental Plasmodium falciparum Malaria on the Profile of Some Oxidative Stress Biomarkers in Women Living in Yaoundé, Cameroon

et al. 2015

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“…4-HNE has received little attention by malariologists as yet, although elevated levels of free, unconjugated 4-HNE had been described in RBCs of P. vinckei -infected mice as early as 1988 [ 41 ]; one study reported the growth inhibition of in vitro cultured parasites by 4-HNE [ 42 ], and the general presence of oxidative stress in malaria was detected long ago [ 43 – 46 ].…”

Section: 4-hne Production In Malariamentioning

confidence: 99%

Role of the Lipoperoxidation Product 4-Hydroxynonenal in the Pathogenesis of Severe Malaria Anemia and Malaria Immunodepression

Schwarzer

Arese

Skorokhod

2015

Oxidative Medicine and Cellular Longevity

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Oxidative stress plays an important role in the pathogenesis of falciparum malaria, a disease still claiming close to 1 million deaths and 200 million new cases per year. Most frequent complications are severe anemia, cerebral malaria, and immunodepression, the latter being constantly present in all forms of malaria. Complications are associated with oxidative stress and lipoperoxidation. Its final product 4-hydroxynonenal (4-HNE), a stable yet very reactive and diffusible molecule, forms covalent conjugates with proteins, DNA, and phospholipids and modulates important cell functions at very low concentrations. Since oxidative stress plays important roles in the pathogenesis of severe malaria, it appears important to explore the role of 4-HNE in two important malaria complications such as malaria anemia and malaria immunodepression where oxidative stress is considered to be involved. In this review we will summarize data about 4-HNE chemistry, its biologically relevant chemical properties, and its role as regulator of physiologic processes and as pathogenic factor. We will review studies documenting the role of 4-HNE in severe malaria with emphasis on malaria anemia and immunodepression. Data from other diseases qualify 4-HNE both as oxidative stress marker and as pathomechanistically important molecule. Further studies are needed to establish 4-HNE as accepted pathogenic factor in severe malaria.

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“…Oxidative stress, generally described as an imbalance between the formation of free radicals, such as reactive oxygen species (ROS), and protective antioxidant defense molecules within cells and tissues, leads to cellular damage to lipids, proteins, RNA, and DNA. Recently, oxidative stress has been documented to play a crucial role in pregnancy outcome in some mouse models of PM [24,26,27] and is implicated in human populations experiencing malaria during pregnancy [18,19] as well as other types of pregnancy complications [38][39][40]. To interrogate the role of oxidative stress in our models, placentae from serially sacrificed mice were evaluated for alterations in antioxidant gene expression by RT-qPCR (Fig.…”

Section: Resultsmentioning

confidence: 99%

Novel murine models of post-implantation and midgestional malaria-induced preterm birth

Andrew

Cooper

Moore

2021

Preprint

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Despite major advances made in malaria treatment and control over recent decades, the development of new models for studying disease pathogenesis remains a vital part of malaria research efforts. The study of malaria infection during pregnancy is particularly reliant on mouse models, as a means of circumventing many challenges and costs associated with pregnancy studies in endemic human populations. Here, we introduce three novel murine models that will further our understanding of how post-implantation and midgestional malaria infection affects pregnancy outcomes. When C57BL/6J (B6) mice are infected with Plasmodium chabaudi chabaudi AS on either embryonic day (E) 6.5, 8.5, or 10.5, preterm birth occurs in all animals by E16.5, E17.5, or E18.5 respectively, with no evidence of intrauterine growth restriction. We found that the time to delivery, placental inflammatory and antioxidant transcript upregulation, and the relationships between parasitemia and transcript expression prior to preterm birth are different based on the embryonic day of infection. On the day before preterm delivery, E6.5 infected mice did not experience significant upregulation of the inflammatory or antioxidant gene transcripts examined; however, parasitemia correlated positively with Il1β , Cox1 , and Hmox1 placental transcript abundance. E8.5 infected mice had elevated transcripts for Ifn g , Tnf , Il10 , Cox1 , Cox2 , Sod1 , Sod2 , Cat , and Nrf2 , while Sod3 was the only transcript that correlated with parasitemia. Finally, E10.5 infected mice had elevated transcripts for Ifn g only, with a tendency for Tnf transcripts to correlate with parasitemia. Tumor necrosis factor deficient (TNF -/- ) and TNF receptor 1 deficient (TNFR1 -/- ) mice infected on E8.5 experienced preterm birth at the same time as B6 controls. Further characterization of these models is necessary to discover new and/or existing mechanism(s) or trigger(s) responsible for malaria-driven preterm birth that is determined by gestational age upon maternal infection, parasite-host dynamics, or both.

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Evaluation of oxidative stress and antioxidant status of pregnant women suffering from malaria in Cameroon

Abstract: ABSTRACT

Cited by 20 publications

References 32 publications

Impact of Placental Plasmodium falciparum Malaria on the Profile of Some Oxidative Stress Biomarkers in Women Living in Yaoundé, Cameroon

Impact of Placental Plasmodium falciparum Malaria on the Profile of Some Oxidative Stress Biomarkers in Women Living in Yaoundé, Cameroon

Role of the Lipoperoxidation Product 4-Hydroxynonenal in the Pathogenesis of Severe Malaria Anemia and Malaria Immunodepression

Novel murine models of post-implantation and midgestional malaria-induced preterm birth

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