Evaluation of Oxidative Stress in Patients with Cancer

Hristozov, D.; Gadjeva, V.; Vlaykova, Tatyana; Dimitrov, G

doi:10.1076/apab.109.4.331.4248

Cited by 57 publications

(22 citation statements)

References 27 publications

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“…Namely, in all examined groups higher levels of LOOH were recorded than in controls, though the elevation was not significant only in patients with polypus endometrii. The increase in LOOH may also be due to the impaired antioxidant system as observed in the previous studies (26,22). We also observed that circulating levels of lipid hydroperoxides are generally higher in subjects with either form of hyperplasia or adenocarcinoma than those found in polypus or myoma patients.…”

Section: Discussionsupporting

confidence: 54%

Antioxidative biomarkers and cancerogenesis

Pajovic¹,

Saicic²,

Pejić³

et al. 2006

Jugoslav Med Biohem

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Cancer development includes three major steps, initiation, promotion and progression, in which oxidative stress is involved. Oxidative stress is defined as an imbalance between the levels of prooxidants and antioxidants in favour of the former and resulting in irreversible cell damage. We examined the lipid peroxidation levels and antioxidant enzyme activities in women diagnosed with different forms of uterine cell transformations in order to evaluate the extent of oxidative stress in the blood of such patients. Blood samples of healthy subjects and gynecological patients were collected and subjected to assays for superoxide dismutase, catalase, glutathione peroxidase, glutathione reductase and lipid hydroperoxides. The results show that alterations of the measured parameters vary with the enzyme type and diagnosis. However, both reduction in antioxidants and elevation of lipid peroxidation were observed in general. In addition, lipid hydroperoxide levels were negatively correlated with superoxide dismutase and glutathione peroxidase activities, as well as positively correlated with catalase activity. The obtained results also show that perturbation of the antioxidant status is more pronounced in blood of patients with premalignant (hyperplastic) and malignant (adenocarcinoma) lesions, compared to those with benign uterine changes such as polypus and myoma.

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Section: Discussionsupporting

confidence: 54%

Antioxidative biomarkers and cancerogenesis

Pajovic¹,

Saicic²,

Pejić³

et al. 2006

Jugoslav Med Biohem

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“…Previous studies have reported both increased and decreased erythrocytes catalase activity in oral cancer patients. [38][39] In the present study, erythrocyte catalase activity was significantly elevated in WHT and patients with OPC than NHT. However, erythrocyte catalase activity was decreased in oral cancer patients than OPC.…”

Section: Discussionmentioning

confidence: 76%

Role of nitric oxide and antioxidant enzymes in the pathogenesis of oral cancer

Patel¹,

Shah²,

Shukla³

et al. 2009

J Can Res Ther

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Background: Oral cancer is the leading malignancy in India. Nitric oxide and antioxidant enzymes play an important role in etiology of oral cancer. Therefore, the present study evaluates nitric oxide and antioxidant enzyme levels in healthy individual without tobacco habits (NHT, N=30) and healthy individuals with tobacco habits (WHT, n=90), patients with oral precancers (OPC, n=15) and oral cancer patients (n=126).Materials and Methods: Blood samples were collected from the subjects. NO 2 +NO 3 (nitrite+nitrate), superoxide dismutase (SOD) and catalase levels were estimated using highly specific spectrophotometeric methods. Statistical analysis was done by SPSS statistical software version 10.Results: Mean plasma NO 2 +NO 3 levels were elevated in patients with OPC and oral cancer patients as compared to the controls. Mean activities of erythrocyte SOD and catalase were higher in WHT than NHT. Erythrocyte SOD and catalase levels were higher in WHT and patients with OPC as compared to NHT. The erythrocyte SOD and catalase activities were lower in oral cancer patients than patients with OPC. The erythrocyte SOD activity was higher in advanced oral cancer than the early disease. Erythrocyte catalase activity was lower in poorly differentiated tumors than well and moderately differentiated tumors. Pearson's correlation analysis revealed that alterations in plasma NO 2 +NO 3 levels were negatively associated with changes in erythrocyte SOD activities. Conclusion:The data revealed that the alterations in antioxidant activities were associated with production of nitric oxide in oral cancer, which may have significant role in oral carcinogenesis.

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“…Hristozov et al, found significantly higher levels of lipid peroxidation products (malonaldehyde) in early and advanced cancers in comparison to controls. [38] Das, suggested that tumor cells have relatively low amounts of SOD, which quenches superoxide anion and as a result of a higher level of aerobic metabolism, higher concentration of hydroxyl ion compared with normal cells. He also suggested that ionizing ration radiation and chemotherapeutic agents like anthracyclines and bleomycin exert their anticancer effect by the producing free radicals.…”

Section: Mode Of Actionmentioning

confidence: 98%

Future prospective and current status of antioxidants in premalignant and malignant lesions of oral cavity

Rai¹,

Malik²,

Misra³

et al. 2014

Int J Nutr Pharmacol Neurol Dis

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In the late 19 th and early 20 th century, extensive study was devoted to the use of antioxidants in important industrial processes, such as the prevention of metal corrosion, vulcanization of rubber, and polymerization of fuels in the fouling of internal combustion engines. In recent years, there is an upsurge in the areas related to newer developments in prevention of disease, especially the role of free radicals and antioxidants. So it will be pertinent to examine the possible role of 'free radicals' in disease and 'antioxidants' in its prevention. Antioxidants are intimately involved in the prevention of cellular damage-the common pathway for cancer and a variety of diseases. The reversal or suppression of premalignant lesions is an important strategy against carcinogenesis for the prevention of cancer. Whether antioxidants can protect the human population from diseases like leukoplakia, lichen planus, carcinoma in situ or oral cancer and also from cancers of the upper aero digestive tract i.e. larynx, pharynx and esophagus and increase the life expectancy is still controversial. This article deals with the action of various chemopreventive agents along with brief review of literature about the outcome of effect of antioxidant on potentially premalignant and malignant lesions of oral mucosa.

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Evaluation of Oxidative Stress in Patients with Cancer

Cited by 57 publications

References 27 publications

Antioxidative biomarkers and cancerogenesis

Antioxidative biomarkers and cancerogenesis

Role of nitric oxide and antioxidant enzymes in the pathogenesis of oral cancer

Future prospective and current status of antioxidants in premalignant and malignant lesions of oral cavity

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