Evaluation of penile vascular status in men with epilepsy with erectile dysfunction

Hamed, Sherifa A.; Hermann, Bruce P.; Moussa, Ehab M.; Youssef, Ahmad H.; Rageh, Tarek A.; Elserogy, Yaser E.; NasrEldin, Eman

doi:10.1016/j.seizure.2014.12.002

Cited by 14 publications

(11 citation statements)

References 49 publications

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“…Ascertained by GRADEpro, the rates of events of SD on average were 59.1% and 19.5% for female PWE and healthy individuals, respectively; and 58.6% and 9.8% for male PWE and the healthy controls, respectively. These results were in line with the findings of some other pertinent trials failing to meet our pre-defined eligibility criteria [13,[28][29][30][31], which showed the suspicious association between epilepsy and SD. Sensitivity analyses suggested that the quantification of the risk for the SD in PWE remained prominently high in nearly all of the studies, indicating our findings were robust.…”

Section: Discussionsupporting

confidence: 90%

Association between epilepsy and risk of sexual dysfunction: A meta-analysis

Zhao

Tang

Xie

et al. 2019

Seizure

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A B S T R A C TPurpose: Sexual functioning is an important factor influencing quality of life. Mounting evidence suggests that both male and female patients with epilepsy (PWE) have an increased risk of developing sexual dysfunction (SD). The aim of this meta-analysis was to quantify the association between epilepsy and the risk of SD. Methods: PubMed, Embase, and Cochrane Library database were systematically searched to identify the pertinent studies focusing on the association between epilepsy and SD. Relative risk (RR) for SD with 95% confidence interval (CI) was calculated. The overall quality of the evidence was generated by applying the GRADE-profiler. This meta-analysis was registered on the PROSPERO (ID: CRD42018103572, http://www.crd.york.ac.uk/ PROSPERO). Results: Nine studies (3 cross-sectional, 5 case-control, and 1 cohort) were included in this meta-analysis, for a total of 1556 subjects and 599 cases of epilepsy. Synthetic results demonstrated that epilepsy was associated with an increased risk of female SD (6 studies, pooled RR = 2.69, 95%CI: 1.48-4.89, P = 0.001; heterogeneity: I 2 = 88.9%, P < 0.001) as well as male SD (3 studies, pooled RR = 4.85, 95%CI: 2.01-11.7, P < 0.001; heterogeneity: I 2 = 74.2%, P = 0.021). The GRADE-profiler showed that the rate of events of SD on average in the PWE and the controls were 383/659 (58.1%) and 168/1017 (16.5%), respectively. The quality of evidence across outcomes was MODERATE. Conclusions: Epilepsy is significantly associated with an increased risk of SD in both sexes. These findings suggest that both clinicians and patients should recognize that epilepsy has a potential hazardous effect on sexual functioning.

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Section: Discussionsupporting

confidence: 90%

Association between epilepsy and risk of sexual dysfunction: A meta-analysis

Zhao

Tang

Xie

et al. 2019

Seizure

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“…The IIEF has been useful for evaluating the sexual function of patients with cardiovascular and metabolic diseases [23], psychiatric disorders [24], and epilepsy [5][6][7]22]. A score of ≥ 22 corresponded to an absence of ED, whereas scores of 17-21, 8-16, and 1-7 corresponded to mild, moderate, and severe ED, respectively.…”

Section: Main Outcome Measuresmentioning

confidence: 99%

“…Reproductive and endocrine system disorders were associated with epilepsy as early as 1950 [2], and the prevalence of reproductive endocrine disorders and sexual dysfunction is significantly higher in males with epilepsy than in the general population [3][4][5][6][7]. The mechanisms related to reproductive and endocrine changes in male patients with epilepsy are still not completely understood, but abnormalities in central nervous system control, peripheral hormone levels, or antiepileptic drugs (AEDs) are influencing factors [5,8].…”

Section: Introductionmentioning

confidence: 99%

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How predictable is the erectile function of patients with epilepsy?

Vieira

Ronsoni

Hohl

et al. 2015

Epilepsy & Behavior

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“…In terms of etiology both physical (ED in men due to circulatory disorders) and psychological factors (inadequate interpersonal associations, psychiatric illness) are responsible for sexual dysfunction. Another cause of sexual dysfunction is the use of drugs such as anti-hypertensive (Fogari et al 1998), anti-psychotics (Baldwin and Birtwistle 1997), anti-depressants (Baldwin et al 1997; Goldstein and Goodnick 1998) and anti-epileptic drugs (AEDs) (Hamed et al 2015; Kirmani et al 2014; Lombardi et al 2015; Meryn 2015; Svalheim et al 2015; Urso et al 2014; Kaufman et al 2015; Sivaraaman and Mintzer 2011; Kaufman and Struck 2011b). The link between sexual dysfunction and drug induced as opposed to disease induced effects is complicated, and the case of epilepsy and AEDs has received less attention than one might expect.…”

Section: Introductionmentioning

confidence: 99%

The relationship between epilepsy and sexual dysfunction: a review of the literature

2016

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Background and objectivesRegardless of the disease states that people suffer from, maintaining sexual function is an important indicator of quality of life. The objective of this review was to figure out the relationship between epilepsy, antiepileptic drugs (AEDs) and sexual dysfunction.ResultsIn various epidemiological and clinical studies, epilepsy has been correlated with a reduction in sexual function. This sexual dysfunction is not always detected in epileptic patients until systematic efforts are put in place, as part of the assessment and treatment process. Therefore, precise evaluations of the incidence of treatment related sexual dysfunction in epileptic patients is still lacking.ConclusionsThis literature review concluded that sexual function is influenced by the pathophysiology of epilepsy, as well as through the use of AEDs. To maximize quality of care in patients with epilepsy and those patients with other disease states who receive AEDs, it is important to address the status of the patient’s sexual function as part of the initial routine assessment and with any treatment related follow-up. Minimizing the effects of AED related sexual dysfunction can be achieved by raising awareness among patients, providing education and training for physicians regarding sexual dysfunction and obtaining a baseline sexual history from the patient so are important recommendations. In addition, systematic studies are needed to explore the risk and mechanism of such treatment related side effects on sexual function.

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Evaluation of penile vascular status in men with epilepsy with erectile dysfunction

Abstract: Vasculogenic ED is frequent with epilepsy and its relationship to systemic atherosclerosis cannot be excluded.

Cited by 14 publications

References 49 publications

Association between epilepsy and risk of sexual dysfunction: A meta-analysis

Association between epilepsy and risk of sexual dysfunction: A meta-analysis

How predictable is the erectile function of patients with epilepsy?

The relationship between epilepsy and sexual dysfunction: a review of the literature

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