Evaluation of perinatal arterial ischemic stroke using noninvasive arterial spin labeling perfusion MRI

Vis, Jill B. De; Petersen, Esben Thade; Kersbergen, Karina J.; Alderliesten, Thomas; Vries, Linda S. de; Bel, Frank van; Groenendaal, Floris; Lemmers, Petra; Hendrikse, Jeroen; Benders, Manon J. N. L.

doi:10.1038/pr.2013.111

Cited by 41 publications

(18 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…For instance, the basal ganglia and thalamus are known to be more susceptible to damage in HIE . Another example is perinatal arterial ischemic stroke, and De Vis et al reported that cerebral oxygen saturation was higher in the infarcted hemisphere than the contralateral hemisphere . The ability to measure regional Y v will provide new insights into the disease pathology and guide therapy on an individual basis.…”

Section: Discussionmentioning

confidence: 99%

Vessel‐specific quantification of neonatal cerebral venous oxygenation

Jiang

Parkinson

et al. 2019

Magnetic Resonance in Med

View full text Add to dashboard Cite

Purpose: Noninvasive measurement of cerebral venous oxygenation (Y v ) in neonates is important in the assessment of brain oxygen extraction and consumption, and may be useful in characterizing brain development and neonatal brain diseases.This study aims to develop a rapid method for vessel-specific measurement of Y v in neonates. Methods: We developed a pulse sequence, named accelerated T 2 -relaxation-underphase-contrast (aTRUPC), which consists of velocity-encoding phase-contrast module to isolate pure blood signal, flow-insensitive T 2 -preparation to quantify blood T 2 , and turbo-field-echo (TFE) scheme for rapid image acquisition, which is critical for neonatal MRI. A series of studies were conducted. First, the pulse sequence was optimized in terms of TFE factor, velocity encoding (VENC), and slice thickness for best sensitivity. Second, to account for the influence of TFE acquisition on T 2 quantification, simulation and experiments were conducted to establish the relationship between TFE-T 2 and standard T 2 . Finally, the complete aTRUPC sequence was applied on a group of healthy neonates and normative Y v values were determined. Results: Optimal parameters of aTRUPC in neonates were found to be a TFE factor of 15, VENC of 5 cm/s, and slice thickness of 10 mm. The TFE-T 2 was on average 3.9% lower than standard T 2 . These two measures were strongly correlated (R 2 = 0.86); thus their difference can be accounted for by a correction equation, T 2,standard = 1.2002 × T 2,TFE − 10.6276. Neonatal Y v values in veins draining cortical brain and those draining central brain were 64.8 ± 2.9% and 70.2 ± 3.3%, respectively, with a significant difference (P =.02). Conclusion:The aTRUPC MRI has the potential to provide vessel-specific quantification of cerebral Y v in neonates. |JIANG et Al.

show abstract

Section: Discussionmentioning

confidence: 99%

Vessel‐specific quantification of neonatal cerebral venous oxygenation

Jiang

Parkinson

et al. 2019

Magnetic Resonance in Med

View full text Add to dashboard Cite

show abstract

“…Calculating the cerebral tissue oxygen extraction may offer better correlation with brain injury than regional cerebral oximetry alone [ 20 , 23 ]. Altered brain oxygen consumption that may be related to dysfunctional autoregulation [ 24 ] and regional differences in cerebral perfusion [ 25 ] have been described in preterm neonates and neonates with HIE or perinatal arterial ischemic strokes. Methods to assess autoregulation by correlating blood pressure with tissue oxygen levels or oxygen extraction measured by NIRS are being tested in neonates [ 26 – 28 ].…”

Section: Discussionmentioning

confidence: 99%

A pilot cohort study of cerebral autoregulation and 2-year neurodevelopmental outcomes in neonates with hypoxic-ischemic encephalopathy who received therapeutic hypothermia

et al. 2015

View full text Add to dashboard Cite

BackgroundNeurodevelopmental disabilities persist in survivors of neonatal hypoxic-ischemic encephalopathy (HIE) despite treatment with therapeutic hypothermia. Cerebrovascular autoregulation, the mechanism that maintains cerebral perfusion during changes in blood pressure, may influence outcomes. Our objective was to describe the relationship between acute autoregulatory vasoreactivity during treatment and neurodevelopmental outcomes at 2 years of age.MethodsIn a pilot study of 28 neonates with HIE, we measured cerebral autoregulatory vasoreactivity with the hemoglobin volume index (HVx) during therapeutic hypothermia, rewarming, and the first 6 h of normothermia. The HVx, which is derived from near-infrared spectroscopy, was used to identify the individual optimal mean arterial blood pressure (MAPOPT) at which autoregulatory vasoreactivity is greatest. Cognitive and motor neurodevelopmental evaluations were completed in 19 children at 21–32 months of age. MAPOPT, blood pressure in relation to MAPOPT, blood pressure below gestational age + 5 (ga + 5), and regional cerebral oximetry (rSO2) were compared to the neurodevelopmental outcomes.ResultsNineteen children who had HIE and were treated with therapeutic hypothermia performed in the average range on cognitive and motor evaluations at 21–32 months of age, although the mean performance was lower than that of published normative samples. Children with impairments at the 2-year evaluation had higher MAPOPT values, spent more time with blood pressure below MAPOPT, and had greater blood pressure deviation below MAPOPT during rewarming in the neonatal period than those without impairments. Greater blood pressure deviation above MAPOPT during rewarming was associated with less disability and higher cognitive scores. No association was observed between rSO2 or blood pressure below ga + 5 and neurodevelopmental outcomes.ConclusionIn this pilot cohort, motor and cognitive impairments at 21–32 months of age were associated with greater blood pressure deviation below MAPOPT during rewarming following therapeutic hypothermia, but not with rSO2 or blood pressure below ga + 5. This suggests that identifying individual neonates’ MAPOPT is superior to using hemodynamic goals based on gestational age or rSO2 in the acute management of neonatal HIE.Electronic supplementary materialThe online version of this article (doi:10.1186/s12883-015-0464-4) contains supplementary material, which is available to authorized users.

show abstract

“…In addition, NIRS presents as an effective research tool in clinical studies. The concentration of oxy-Hb and deoxy-Hb obtained by NIRS could be measured, calculated and analyzed, evaluating hemodynamic, oxygenation changes and cortical function, thus widely used in assessing the effects of different therapies or the evolution of diseases (20, 21). Ferrante et al combined functional electrical stimulation and time-domain NIRS (TD NIRS) to examine muscular metabolism on post-stroke patients and the result indicated metabolic dysfunction of muscles seemed to be local and unilateral (22).…”

Section: Other Applicationsmentioning

confidence: 99%

“…NIRS combined with BCI offers great potential as a therapeutic tool (18, 19). In addition, NIRS has used in several clinical studies (20, 21), reflecting hemodynamic or oxygenation changes of brain, as well as in evaluation of the risks for postoperative stroke and muscle metabolism (22). NIRS has shown to be an effective and promising method, however, its clinical value still remains controversial (23).…”

Section: Introductionmentioning

confidence: 99%

A Systemic Review of Functional Near-Infrared Spectroscopy for Stroke: Current Application and Future Directions

et al. 2019

View full text Add to dashboard Cite

Background: Survivors of stroke often experience significant disability and impaired quality of life. The recovery of motor or cognitive function requires long periods. Neuroimaging could measure changes in the brain and monitor recovery process in order to offer timely treatment and assess the effects of therapy. A non-invasive neuroimaging technique near-infrared spectroscopy (NIRS) with its ambulatory, portable, low-cost nature without fixation of subjects has attracted extensive attention.Methods: We conducted a comprehensive literature review in order to review the use of NIRS in stroke or post-stroke patients in July 2018. NCBI Pubmed database, EMBASE database, Cochrane Library and ScienceDirect database were searched.Results: Overall, we reviewed 66 papers. NIRS has a wide range of application, including in monitoring upper limb, lower limb recovery, motor learning, cortical function recovery, cerebral hemodynamic changes, cerebral oxygenation, as well as in therapeutic method, clinical researches, and evaluation of the risk for stroke.Conclusions: This study provides a preliminary evidence of the application of NIRS in stroke patients as a monitoring, therapeutic, and research tool. Further studies could give more emphasize on the combination of NIRS with other techniques and its utility in the prevention of stroke.

show abstract

Evaluation of perinatal arterial ischemic stroke using noninvasive arterial spin labeling perfusion MRI

Cited by 41 publications

References 24 publications

Vessel‐specific quantification of neonatal cerebral venous oxygenation

Vessel‐specific quantification of neonatal cerebral venous oxygenation

A pilot cohort study of cerebral autoregulation and 2-year neurodevelopmental outcomes in neonates with hypoxic-ischemic encephalopathy who received therapeutic hypothermia

A Systemic Review of Functional Near-Infrared Spectroscopy for Stroke: Current Application and Future Directions

Contact Info

Product

Resources

About