Evaluation of peritoneal CEA levels following colorectal cancer surgery

Berkovich, Liron; Shpitz, Baruch; Ghinea, Ronen; Greemland, Itzhak; Kravtsov, Vladimir; Kidron, Debora; Mishaeli, Moshe; Avital, Shmuel

doi:10.1002/jso.23676

Cited by 6 publications

(7 citation statements)

References 16 publications

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“…Several studies have demonstrated a significant elevation in CEA levels within the postoperative peritoneal drainage fluid of patients with gastrointestinal tumours. This surge in CEA levels has been closely correlated with tumour invasion depth, lymph node metastasis, and clinical staging, thereby serving as a potential prognostic indicator [ 18 , 19 ]. Wei et al inferred that laparoscopic radical gastrectomy does not increase the shedding of gastric cancer cells by comparing CEA levels in the peritoneal lavage fluid [ 20 ].…”

Section: Discussionmentioning

confidence: 99%

Disparities of tumour markers in intraperitoneal drainage fluid between laparoscopic and open radical gastrectomy for gastric cancer

Guo,

Zheng,

Chen

et al. 2024

Videosurgery and Other Miniinvasive Techniques

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Introduction: Despite the remarkable progress in minimally invasive surgery, the potential association between laparoscopic gastrectomy and the risk of peritoneal metastasis remains uncertain. Aim: To investigate variations in tumour markers in intraperitoneal drainage fluid between laparoscopic radical gastrectomy and open radical gastrectomy for gastric cancer. Material and methods: A total of 106 patients diagnosed with gastric cancer between July 2018 and November 2020 were included in this study, 45 of whom underwent laparoscopic radical gastrectomy (laparoscopic group) and 61 underwent open radical gastrectomy (open group).Variations in the levels of carcinoembryonic antigen (CEA), cancer antigen 125 (CA125), cancer antigen 199 (CA199), and a-fetoprotein (AFP) in the intraperitoneal drainage fluid were compared and analysed on postoperative days (PODs) 1, 2, 3, and 5 between the two groups. Additionally, the postoperative 3-year survival rates between the two groups were compared and analysed. Results: No significant differences in CEA, CA199, and AFP levels in the intraperitoneal drainage fluid were observed between the two groups on postoperative days (PODs) 1, 2, 3, and 5 (p > 0.05). However, the level of CA125 in the intraperitoneal drainage fluid of the laparoscopic group was notably higher than that of the open group on POD 2 (p < 0.05); however, there were no significant differences between the two groups on PODs 1, 3, and 5 (p > 0.05). There was no significant difference in the 3-year postoperative survival rates between the two groups. Conclusions: There were no significant differences in CEA, CA125, CA199, and AFP levels in the intraperitoneal drainage fluid between laparoscopic radical gastrectomy and open radical gastrectomy for gastric cancer, confirming from another perspective that laparoscopic radical gastrectomy does not increase the risk of intraperitoneal metastasis.

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Section: Discussionmentioning

confidence: 99%

Disparities of tumour markers in intraperitoneal drainage fluid between laparoscopic and open radical gastrectomy for gastric cancer

Guo,

Zheng,

Chen

et al. 2024

Videosurgery and Other Miniinvasive Techniques

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“…Given that the progression of CRC is dependent on both local and systemic inflammatory responses, these indices have been used to develop CRC-specialized screening markers or scoring systems, namely, the single neutrophil-to-lymphocyte ratio (NLR), lymphocyte-to-monocyte ratio (LMR) (13)(14)(15), CRC tumor markers (CA19-9 and CEA), modified Glasgow Prognostic Score (mGPS, albumin, and C-reactive protein in serum) (16,17), systemic inflammation score (SIS, serum albumin, and LMR) (18), and fecal-based testing (19,20). However, the lack of sensitivity of these methods makes early diagnosis of CRC challenging (21). Therefore, the development of a more effective, noninvasive, and high-throughput method for disease-progress surveillance is necessary.…”

Section: Introductionmentioning

confidence: 99%

Metabolomic Comparison of Patients With Colorectal Cancer at Different Anticancer Treatment Stages

Deng

Luo

et al. 2022

Front. Oncol.

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BackgroundThe difficulties of early diagnosis of colorectal cancer (CRC) result in a high mortality rate. The ability to predict the response of a patient to surgical resection or chemotherapy may be of great value for clinicians when planning CRC treatments. Metabolomics is an emerging tool for biomarker discovery in cancer research. Previous reports have indicated that the metabolic profile of individuals can be significantly altered between CRC patients and healthy controls. However, metabolic changes in CRC patients at different treatment stages have not been explored.MethodsTo this end, we performed nuclear magnetic resonance (NMR)-based metabolomic analysis to determine metabolite aberrations in CRC patients before and after surgical resection or chemotherapy. In general, a total of 106 urine samples from four clinical groups, namely, healthy volunteers (n = 31), presurgery CRC patients (n = 25), postsurgery CRC patients (n = 25), and postchemotherapy CRC patients (n = 25), were collected and subjected to further analysis.ResultsIn the present study, we identified five candidate metabolites, namely, N-phenylacetylglycine, succinate, 4-hydroxyphenylacetate, acetate, and arabinose, in CRC patients compared with healthy individuals, three of which were reported for the first time. Furthermore, approximately ten metabolites were uniquely identified at each stage of CRC treatment, serving as good candidates for biomarker panel selection.ConclusionIn summary, these potential metabolite candidates may provide promising early diagnostic and monitoring approaches for CRC patients at different anticancer treatment stages.

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“…Therefore, CEA is considered as a tumor marker in clinical findings. 18,19) In medicine, the CEA test contributes to the early and clearly identification of etiologies so that appropriate and effective preventive and curative measures can be taken timely.…”

Section: Introductionmentioning

confidence: 99%

Characterization of Gd2O3:Eu3+ Nanocomplexes Conjugate with IgG for the Identification of CEA Tumor Cells

Lien

Diep

et al. 2020

Mater. Trans.

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In this paper, the Gd 2 O 3 :Eu 3+ nanospheres with the ratio Eu 3+ /Gd 3+ of 6% mol were successfully synthesized by a multi-step chemical method with the mean nanoparticles size of about 200 to 220 nm and a low standard deviation. The morphology, structure and optical behavior of as-synthesized and annealed Gd 2 O 3 :6%Eu 3+ samples were investigated by field-emission scanning electron microscopy (FESEM), X-ray diffractions (XRD), and photoluminescence spectroscope (PL) The luminescence lifetime of samples was also investigated and discussed. The biomedical nanocomplexes of Gd 2 O 3 :6%Eu 3+ with IgG were fabricated by glutaraldehyde linking after covering nanospheres with amino Silica. The luminescent nanocomplexes Gd 2 O 3 :6%Eu 3+ @Silica-NH 2 -IgG with different concentrations have been incubated with CEA tumor cells to investigate and evaluate the detection capacity by using a fluorescence optical microscopy for the early detection and treatment of cancer.

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Evaluation of peritoneal CEA levels following colorectal cancer surgery

Abstract: Postoperative pCEA levels may be significantly elevated following a curative resection for CRC. Its significance within patient's prognostic evaluation remains to be studied. Inclusion of patient's follow-up data may reveal the significance of elevated pCEA levels following CRC resection.

Cited by 6 publications

References 16 publications

Disparities of tumour markers in intraperitoneal drainage fluid between laparoscopic and open radical gastrectomy for gastric cancer

Disparities of tumour markers in intraperitoneal drainage fluid between laparoscopic and open radical gastrectomy for gastric cancer

Metabolomic Comparison of Patients With Colorectal Cancer at Different Anticancer Treatment Stages

Characterization of Gd<sub>2</sub>O<sub>3</sub>:Eu<sup>3+</sup> Nanocomplexes Conjugate with IgG for the Identification of CEA Tumor Cells

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