Evaluation of Pharmacokinetic Interactions Between the New SGLT2 Inhibitor SHR3824 and Valsartan in Healthy Chinese Volunteers

Huang, Yunzhe; Liu, Ran; Wang, Yaqin; Liu, Gege; Wang, Changmao; Chen, Xinyan; Jia, Yuanwei; Shen, Jie

doi:10.1016/j.clinthera.2022.06.001

Cited by 12 publications

(4 citation statements)

References 30 publications

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“…These reactions have attracted much attention due to their ability to produce complex polycyclic structures ( e.g. natural products, pharmaceuticals, or valuable intermediates) 11–55 (Scheme 1).…”

Section: From Classical Cycloadditions To Higher-order Cycloadditionsmentioning

confidence: 99%

Recent advances in metal-free catalytic enantioselective higher-order cycloadditions

Zhang,

Wang

2024

Org. Chem. Front.

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Section: From Classical Cycloadditions To Higher-order Cycloadditionsmentioning

confidence: 99%

Recent advances in metal-free catalytic enantioselective higher-order cycloadditions

Zhang,

Wang

2024

Org. Chem. Front.

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“…Saraya et al (2022) adopted a spectrofluorimetric method with a lower limit of quantification (LLOQ) up to 8.57 ng/ml and sample consumption up to 1 ml for a single assay alone; in addition, this method was time consuming, with 15 min being required for the heating step of the substitution reaction alone. Diabetes and hypertension are common elderly diseases, which increase the risk of renal complications (Huang et al, 2022). Taking vonoprazan in patients with renal dysfunction could cause drug accumulation in vivo (Echizen, 2016), thus it is necessary to conduct therapeutic drug monitoring in such populations.…”

Section: Introductionmentioning

confidence: 99%

LC–MS/MS method for quick detection of vonoprazan fumarate in human plasma: Development, validation and its application to a bioequivalence study

Chen,

Huang

et al. 2024

Biomedical Chromatography

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A liquid chromatography–tandem mass spectrometry method with vonoprazan fumarate‐d4 as a stable isotope‐labeled internal standard was developed and validated aiming at quantification of vonoprazan fumarate in human plasma for a bioequivalence study. Chromatographic separation was achieved by acetonitrile one‐step protein precipitation using a gradient elution of 0.1% formic acid aqueous solution and acetonitrile with a run time of 3.65 min. Detection was carried out on a tandem mass spectrometer in multiple reaction monitoring mode via a positive electrospray ionization interface. The multiple reaction monitoring mode of precursor–product ion transitions for vonoprazan fumarate and vonoprazan fumarate‐d4 were m/z 346.0 → 315.1 and 350.0 → 316.0, respectively. The linear range was 0.150–60.000 ng/ml. This method was fully validated with acceptable results in terms of selectivity, carryover, lower limit of quantification, calibration curve, accuracy, precision, dilution effect, matrix effect, stability, recovery and incurred sample reanalysis. A successful application of this method was realized in the bioequivalence study of vonoprazan fumarate tablet (20 mg) among healthy Chinese volunteers.

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“…Currently, clinical strategies to alleviate the progression of diabetic nephropathy are limited. The treatment options such as angiotensin II receptor blockers (ARB), sodium–glucose cotransporter-2 (SGLT-2) inhibitors, and angiotensin-converting enzyme (ACE) inhibitors have received much attention for their anti-inflammatory and cardio-protective activities, but their risks and benefits need to be clarified ( Fineberg et al, 2013 ; Hu et al, 2020 ; Huang et al, 2022 ; He et al, 2023 ; Shen et al, 2023 ). The development and progression of diabetic nephropathy involve multiple factors, including inheritance and environment, resulting in the underlying pathogenesis that is still not fully understood.…”

Section: Introductionmentioning

confidence: 99%

Zn(II)–curcumin prevents cadmium-aggravated diabetic nephropathy by regulating gut microbiota and zinc homeostasis

Sun,

Mei,

Wang

et al. 2024

Front. Pharmacol.

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Background: Diabetic nephropathy (DN) is known as the most common complication of diabetes, resulting from a complex inheritance-environment interaction without effective clinical treatments. Herein, we revealed the protective effects and mechanisms of Zn(II)-curcumin, a curcumin derivative, against streptozotocin-induced DN in rats in the presence or absence of cadmium exposure.Methods: The present study focused on investigating the therapy of Zn(II)-curcumin against cadmium-aggravated DN by regulating gut microbiota, metabolism, inflammation and zinc homeostasis based on pathological changes, TLR4/NF-κB signaling pathway, inductively coupled plasma-mass spectrometry (ICP-MS), 16S rRNA gene sequencing and gas chromatography-mass spectrometer (GC-MS).Results: We found Zn(II)-curcumin significantly mitigated the cadmium-aggravated phenotypes of diabetic nephropathy, as indicated by the remission of renal dysfunction, pathological changes, inflammation and zinc dyshomeostasis in streptozotocin-treated rats exposed to cadmium. Administration of Zn(II)-curcumin significantly alleviated the dysbiosis of gut microbiota and the changes of serum metabolite profiles in rats treated with streptozotocin in combination with cadmium. Notably, fecal microbial transplantation identified the ability of Zn(II)-curcumin to regulate renal function, inflammation and zinc homeostasis was partly dependent on the gut microbiota.Conclusion: These findings revealed that Zn(II)-curcumin alleviated cadmium-aggravated diabetic nephropathy by reshaping the gut microbiota and zinc homeostasis, which provided unique insights into the mechanisms of the treatment and prevention of diabetic nephropathy.

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Evaluation of Pharmacokinetic Interactions Between the New SGLT2 Inhibitor SHR3824 and Valsartan in Healthy Chinese Volunteers

Cited by 12 publications

References 30 publications

Recent advances in metal-free catalytic enantioselective higher-order cycloadditions

Recent advances in metal-free catalytic enantioselective higher-order cycloadditions

LC–MS/MS method for quick detection of vonoprazan fumarate in human plasma: Development, validation and its application to a bioequivalence study

Zn(II)–curcumin prevents cadmium-aggravated diabetic nephropathy by regulating gut microbiota and zinc homeostasis

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