Evaluation of Photoprotective Potential and Percutaneous Penetration by Photoacoustic Spectroscopy of the Schinus terebinthifolius Raddi Extract

Abstract

Schinus terebinthifolius is a plant rich in phenolic compounds, which have antioxidant properties and can provide new opportunities for treatment and prevention of diseases mediated by ultraviolet radiation like photoaging and skin cancer. The aim of this study was to evaluate the photoprotective potential and ex vivo percutaneous penetration of the crude extract of Schinus terebinthifolius leaves. The extract was tested for antioxidant activity using the 2,2-diphenyl-1-picrylhydrazyl (DPPH) method and β-carotene bleaching test. The sun protection factor was also evaluated. The ex vivo skin permeation of the emulsion and gel formulations were assayed. Fractionation of the extract resulted in gallic acid, ethyl gallate and a mixture of flavonoids, suggesting derivatives of quercetin and myricetin. The phenolic content of the extract was 384.64 ± 2.60 mg GAE g(-1) extract. The antioxidant activity was superior to butylated hydroxytoluene, in DPPH method, and ascorbic acid and rutin, in β-carotene bleaching assay. The extract showed UV absorption with photoprotector potential in the UVB region. The photoacoustic spectroscopy measurements confirmed absorption in the UV region and topical application of the formulations caused no histological changes in the rats' skin. These results suggest that the crude extract of Schinus terebinthifolius leaves may be a promising natural sunscreen product.

Photoprotection of Fractions Obtained from Phyllanthus Orbicularis Extract against UVB -Induced DNA Damage

“…The skin cancer incidences have been increasing dramatically over the past few years, so, skin protection against UV exposure is a fundamental part of cancer prevention. In this sense, the inhibition of UVB-induced CPDs or ROS formation could be an important approach for the prevention of UVB-skin neoplasic process [2,3,9,14,15].…”

“…Nowadays, the development of sun protection approaches includes compounds with the ability of absorbing UV-radiation in combination with compounds able to decrease the oxidative stress induced by UV. In this sense, numerous phytocompounds have been evaluated as potential photochemopreventive agents due to their absorptive and antioxidative properties [1][2][3][4].…”

Chitosan, zinc oxide and pink pepper essential oil: potential properties and applications

“…Therefore, it did not exhibit antimicrobial action against this microorganism. 56 The pink pepper essential oils showed a promising antioxidant activity in vitro and exhibited cytotoxicity in the fight against breast cancer. The best biological action was localized in the essential oil which comprised the higher sesquiterpene content.…”

trans-RESVERATROL AND ANTIOXIDANT ACTIVITY OF GRAPE (Vitis vinifera sp) BYPRODUCTS

“…The search for uses for such residues and byproducts is important and beneficial to the economy, society, and the environment (DEVESA-REY et al, 2011;Lavelli et al, 2014;PEDROZA et al, 2012). Residues that are produced in wineries are rich in polyphenols, substances that demonstrate health benefits with potential use as antioxidants in food preparations or in the production of phytochemicals (BULLA et al, 2015;SELVI;SAKARIAH, 2003;ROCKENBACH et al, 2011a;ROCKENBACH et al, 2011b;SHINAGAWA et al, 2015). The development of cookies containing grape pomace flour as a replacement for conventional wheat flour, showed significant increase of the content of fibers, antioxidant activity and total phenolic content of the cookies (KARNOPP et al, 2015).…”