Evaluation of phytochemical content, antioxidant, antimicrobial activity and DNA cleavage effect of endemic<i>Linaria corifolia Desf</i>. (Plantaginaceae)

Gül, Melek; Çalı, İlkay Öztürk; Cansaran, Arzu; İdil, Önder; Kulu, İrem; Çelikoğlu, Umut

doi:10.1080/23312009.2017.1337293

Cited by 8 publications

(4 citation statements)

References 30 publications

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“…Polar fraction of Kickxia ramosissima showed good antibacterial, antifungal as well as antioxidant activity. This is also in agreement with other species of family Plantaginaceae [39]. Therefore, these extracts may act as good candidate for antibacterial and/or antifungal drug discovery.…”

Section: Discussionsupporting

confidence: 88%

Protective Effect of Kickxia ramosissima (Wall.) Janchn Extracts Against Pathogenic Bacterial Strains and Free Radicals

et al. 2020

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Plants are the major source of a wide array of antimicrobials and antioxidants. Present study describes the biochemical exploration of the methanol and chloroform extracts of aerial parts of Kickxia ramosissima (Wall.) Janchn. Main objective of study was to verify the antimicrobial and antioxidant value of its extracts. The crude extracts were subjected to different biological activities to explore the traditional medicinal potential of this herb. Antibacterial and antifungal activities were determined by using agar well diffusion and tube dilution assays, respectively, while antioxidant activity was investigated by DPPH free radical scavenging assay, phosphomolybdate assay and reducing power assay. The results indicated that both the extracts of aerial parts showed varied degree of antimicrobial, antifungal and antioxidant activities. Overall, the methanol extract showed comparatively better activities in various assays. It revealed significantly higher activity against all the tested bacterial strains (Pseudomonas spp. > Staphylococcus aureus > Staphylococcus epidermidis > Klebsiella pneumoniae > Escherichia coli). A maximum fungicidal activity (54.8%) has shown by methanol extract against Aspergillus terreus. The highest radical scavenging activity by DPPH method was found in case of methanol extracts (49.8% and IC 50 228.53 µg ml −1 ) at 250 µg ml −1 . In phosphomolybdate method, the highest activity was shown by methanolic extract (0.459 nm) at same concentration. Similarly, the highest activity evaluated by reducing power assay was 0.521 nm at the highest concentration of 250 µg ml −1 . In conclusion, Kickxia ramosissima is a potential candidate for further studies to explore active compounds particularly responsible for antibacterial and antifungal and activities.

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Section: Discussionsupporting

confidence: 88%

Protective Effect of Kickxia ramosissima (Wall.) Janchn Extracts Against Pathogenic Bacterial Strains and Free Radicals

et al. 2020

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“…Also, below-ground ethanol extracts of Leucojum aestivum L. were displayed highly effect on pBR322 plasmid DNA [45]. In a similar study with endemic Linaria corifolia Desf., the above and below-ground ethanol, ethyl acetate and dichloromethane extracts were determined to show protective activity on plasmid DNA [46]. The plasmid DNA results of the mentioned-above studies are compatible with plasmid DNA results in our study.…”

Section: Dna Interactionsupporting

confidence: 88%

Investigation of Some Biological Activities of Extracts Centranthus longiflorus subsp. longiflorus

Kandemir¹,

KANDEMİR²,

Çelikoğlu³

et al. 2020

International Journal of Secondary Metabolite

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In this study, the effects of above and below-ground extracts of Centranthus longiflorus subsp. longiflorus plant, commonly found in Turkey, on antioxidant, antimicrobial and DNA damage were evaluated. Plant extracts were prepared by applying three different solvents (hexane, methanol and ethanol). The antimicrobial activity tests of the extracts were performed using four different standard strains and one yeast. DPPH, total phenolic content calculation and CUPRAC methods were applied for antioxidant activity studies. Additionally, the effects of plant extracts on DNA damage were investigated using pBR322 plasmid DNA. According to the data obtained, especially the below-ground hexane (MIC value:375µg/mL) extract showed more antimicrobial activity than other plant extracts, and it was found to be more effective Gram negative bacteria. The highest antioxidant activity was determined in extracts prepared with above (IC50 value of methanol extract:4.5mg/mL) and below-ground (IC50 value of methanol extract:5.7mg/mL) methanol. The above (93,9 µg GAE/mL) and below-ground (96.9 µg GAE/mL) methanol extracts were seen to have high total phenolic content. It has also been observed that above-ground hexane and methanol extracts have no effect on pBR322 plasmid DNA, but other extracts affect pBR322 plasmid DNA in the direction of degradation or deformation. Especially, the extracts of the above and below-ground ethanol had the effect of completely eliminating the open ring form. Therefore, it was concluded that this taxon could be widely used in the treatment and prevention of oxidative stress-related diseases in the future.

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“…Therefore, studies on the synthesis of new complexes to be used for chemotherapeutic purposes have become very important in recent years. Investigations, primarily to obtain new antimicrobials from plants, are continuing rapidly [31][32]. However, the increasing resistance of microorganisms to chemotherapeutics has made it necessary to synthesize new chemicals.…”

Section: Effects Of Complexes On the Life Of Bacteria And Time-killin...mentioning

confidence: 99%

Synthesis, Characterization, Antimicrobial and Time Killing Activities of New Sulfa-Derived Schiff Bases Coordinated with Cu(II)

et al. 2023

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Synthesis of three Schiff bases of 5-bromo-3-nitro salicylaldehyde containing different sulfonamide group antibiotic compounds and their Cu(II) complexes was carried out. Structures of all compounds were characterized with spectroscopic methods, including Fourier transform infrared, proton nuclear magnetic resonance, and elemental analysis. The in vitro antimicrobial activity of ligands and complexes against Gram-negative and Gram-positive bacteria and the yeast Candida albicans was evaluated. It was determined that the ligand and complexes showed outstanding antimicrobial activity against almost all of the microorganisms tested. It has been observed that the newly synthesized complexes have more antimicrobial effects than the corresponding ligands. It has been determined that the newly synthesized complexes have more antimicrobial effects than the others (E. coli, L. monocytogenes, and C. albicans), especially on Staphylococcus aureus and Pseudomonas aeruginosa.

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Evaluation of phytochemical content, antioxidant, antimicrobial activity and DNA cleavage effect of endemicLinaria corifolia Desf. (Plantaginaceae)

Cited by 8 publications

References 30 publications

Protective Effect of Kickxia ramosissima (Wall.) Janchn Extracts Against Pathogenic Bacterial Strains and Free Radicals

Protective Effect of Kickxia ramosissima (Wall.) Janchn Extracts Against Pathogenic Bacterial Strains and Free Radicals

Investigation of Some Biological Activities of Extracts Centranthus longiflorus subsp. longiflorus

Synthesis, Characterization, Antimicrobial and Time Killing Activities of New Sulfa-Derived Schiff Bases Coordinated with Cu(II)

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