Evaluation of Plasma-Assisted Noninvasive Surgery (PANIS) as a New Technique for Sublimating Large Benign Conjunctival Nevus with Amniotic Membrane Transplantation (AMT); A Clinical Case Report

Abstract

Background: conjunctival nevi are benign ocular lesions with a low risk of malignant transformation to melanoma. Due to cosmetic reasons patients usually consider surgical removal options. In this case report, we are presenting a new approach using plasma-assisted noninvasive surgery (PANIS) with amniotic membrane transplantation (AMT) to sublimate the nevus border and fuse the AMT with the remaining conjunctiva.Case presentation: A 33-year-old man with a history of large conjunctival nevus in his left eye, that its benignity was proved by an expert ophthalmologist through years of examination, has visited our center in September 2020. Plasma spots were used to sublimate the nevus border and fuse AMT with the conjunctiva. The patient was discharged fully satis ed without any complications and no recurrences were seen in a year of follow-up. Visual parameters were not signi cantly changed while the Ocular Surface Disease Index (OSDI) was reduced dramatically.Conclusion: Conjunctival nevi removal using the PANIS method with AMT is a safe, minimally invasive, and inexpensive therapeutic option. Plasma spots are suitable for AMT adhesion to the remaining conjunctiva after the nevus removal.

Innovative Solutions for Swift Enhancement: A Case Series on Filamentary keratitis treatment with Plasma Occlusion of Puncta

“…These safety evaluations confirmed the initiation of human trials to use plasma technology for treating ocular surface diseases such as conjunctival cyst, conjunctivochalasis, pinguecula, pseudophakic bullous keratopathy, conjunctival concretion, pterygium, dry eye disease, and conjunctival nevus. A published case series about the PANIS modality (plasma-assisted noninvasive surgery) with an average follow-up of 6 months proved the safety and efficacy of this novel technique for treating common ocular surface diseases [7,[25][26][27][28][29][30][31][32].…”

PANIS Method: A Cutting-Edge Approach for Lid Margin and Periocular Benign Lesions

“…The PANIS method has been used to treat ocular surface diseases such as conjunctivochalasis, conjunctival cysts, dry eye disease, pinguecula, conjunctival concretion, pseudophakic bullous keratopathy, pterygium, and conjunctival nevus [36][37][38][39][40][41][42][43][44][45][46].…”

Evaluating plasma assisted noninvasive surgery (PANIS) as a new method for pterygium removal; a clinical case series

“…In the other study, concentrations of candidate cytokines as well as duration of inflammation after conjunctival exposure of ALTP were assessed [27]. In the following, this team investigated the outcomes of three plasma-basedapproachesfor treating conjunctival cysts [28], conjunctivochalasis [29], pinguecula [30], and benign conjunctival nevus [31] using the Plexrdevice (GMV, Rocca Priora, RM, Italy). They reported ALTP application as a simple and effective method without serious complications for treating ocular surface disorders.…”