Evaluation of plasma zonulin level and its relationship with inflammatory cytokines in patients with vitiligo

Arslan, Selami; Altunışık, Nihal; Türkmen, Dursun; Uremis, Muhammed Mehdi; Şener, Serpil; Türköz, Yusuf

doi:10.1111/jocd.15493

Cited by 5 publications

(6 citation statements)

References 18 publications

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“…Thus, in a study involving 36 patients with IBD, zonulin levels directly correlated with serum concentrations of IL10, IL17, and IL22 [23]. S. Arslan et al, in a sample of patients with vitiligo, demonstrated the direct correlations between the level of zonulin and IL6, TNFa, and lipopolysaccharide [24]. On the contrary, in a study by Lacombe L.A.C.…”

Section: Discussionmentioning

confidence: 91%

“…Among other things, it was found that the use of larazotide acetate led to a decrease in the severity of intestinal inflammation, as well as a change in the T cells' homeostasis in the spleen and their shift towards an anti-inflammatory phenotype. Thus, an increase in the serum zonulin concentration reflects not only the dysregulation of the barrier function of the small intestine, but also the associated systemic inflammation and changes in the homeostasis in various immune niches, which, in turn, plays an important role in the progression of IBD and the development of extra-intestinal manifestations [24,[26][27][28].…”

Section: Discussionmentioning

confidence: 99%

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The Relationship between Serum Zonulin and Innate Immunity in Patients with Inflammatory Bowel Disease

Khusainova,

Genkel,

Kuznetsova

et al. 2024

Gastroenterology Insights

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The aim of the study was to investigate the relationship between the serum zonulin and the cellular immunity in patients with ulcerative colitis (UC) and Crohn’s disease (CD). The study included 97 patients, 13 (13.4%) patients with CD and 84 (86.6%) patients with UC. The concentration of zonulin in the serum was studied using the ELISA kits. The investigation of the circulated leukocyte subpopulation was carried out through flow cytometry. The functional activity of the circulating neutrophils was studied using the absorption capacity of the monodisperse polystyrene latex particles and indicators of oxygen-dependent metabolism in the nitroblue tetrazolium test. The serum zonulin concentration in CD patients was significantly higher compared with UC patients (p = 0.003). The zonulin concentration directly correlated with the functional activity of the circulating neutrophils. Patients with a zonulin concentration > 472.4 pg/mL had a significantly higher number of band neutrophils (p = 0.0104), CD3+CD8+ cells (p = 0.0212), NK cells (p = 0.0161), and lower–CD19+ cells (p = 0.0034). Among the IBD patients, zonulin was associated with IBD severity. An increase in the serum concentration of zonulin was associated with an increase in the functional activity of circulating neutrophils and an increase in the number of CD3+CD8+ cells, NK cells, and a decrease in the number of CD19+ cells.

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Section: Discussionmentioning

confidence: 91%

Section: Discussionmentioning

confidence: 99%

The Relationship between Serum Zonulin and Innate Immunity in Patients with Inflammatory Bowel Disease

Khusainova,

Genkel,

Kuznetsova

et al. 2024

Gastroenterology Insights

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“…Studies conducted in recent years have reported that increased intestinal permeability may be associated with many systemic, autoimmune, metabolic, neurological, psychiatric, and dermatological conditions. The diseases that have been subjected to investigation regarding the association between zonulin levels and intestinal permeability include type 1 diabetes mellitus, rheumatoid arthritis, vitiligo, celiac disease, inflammatory bowel diseases, systemic lupus erythematosus, Alzheimer’s disease, multiple sclerosis, schizophrenia, psoriasis, rosacea, dermatitis herpetiformis, atopic dermatitis, and alopecia areata 2 3 4 5 6 7 8 9 10 11 . The zonulin protein regulates tight junction permeability between intestinal absorptive cells.…”

Section: Discussionmentioning

confidence: 99%

“…However, well-developed hypotheses include those related to autoimmunity, histamine-releasing factors, and cellular defects. Recent research has demonstrated that the integrity of the intestinal barrier, which is subject to variations influenced by factors, such as dietary choices and contemporary way of life, is a significant contributor to the development of autoimmune diseases 2 3 4 5 6 7 8 9 10 11 . The intestinal epithelium plays a crucial role in the processes of nutritional digestion and absorption, as well as fluid-electrolyte hemostasis.…”

Section: Introductionmentioning

confidence: 99%

“…Elevated zonulin levels increase the intestinal permeability of antigens, stimulates mucosal and systemic inflammation, and triggers the development of autoimmune diseases. Many scientific investigations have been conducted to evaluate the serum levels of zonulin in some dermatological diseases in which autoimmunity is involved in the etiopathogenesis, such as vitiligo, alopecia areata, psoriasis vulgaris, dermatitis herpetiformis, and rosacea 6 7 8 9 10 . Therefore, the primary objective of the present study was to assess the levels of serum zonulin in patients diagnosed with CSU.…”

Section: Introductionmentioning

confidence: 99%

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Assessment of Serum Zonulin Levels in Individuals Diagnosed With Chronic Spontaneous Urticaria

Ünal,

Ülfer

2024

Ann Dermatol

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Background There have been reports indicating a correlation between heightened intestinal permeability and many autoimmune and chronic inflammatory disorders. The involvement of autoimmunity is now recognized as a significant factor in the development of chronic spontaneous urticaria (CSU). Zonulin is an important biomarker that regulates tight junction permeability within cells in the gastrointestinal tract, hence facilitating intestinal permeability. Objective To evaluate the correlation of CSU with intestinal permeability by measuring the serum levels of zonulin in patients diagnosed with CSU. Methods The study included 60 patients diagnosed with CSU and 64 age- and sex-matched healthy individuals as controls. Levels of serum zonulin were determined using the ELISA method. Results Although the serum zonulin value of the patients was higher compared to the controls, the difference did not reach a significant level (24.65±8.49 ng/ml vs. 21.03±7.36 ng/ml, p =0.077). The serum zonulin level had a significant correlation with the urticaria activity score in the CSU group ( p =0.013). The results of the current study revealed that serum zonulin values significantly differed between patients with CSU and healthy controls. Conclusion This study is important in terms of being the first to investigate the serum zonulin levels in CSU. However, there is a need for further studies with larger patient groups.

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Insights into the gut microbiome of vitiligo patients from India

Kumar,

Mahajan,

Kale

et al. 2024

BMC Microbiol

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Background Vitiligo is an autoimmune disease characterized by loss of pigmentation in the skin. It affects 0.4 to 2% of the global population, but the factors that trigger autoimmunity remain elusive. Previous work on several immune-mediated dermatological disorders has illuminated the substantial roles of the gut microbiome in disease pathogenesis. Here, we examined the gut microbiome composition in a cohort of vitiligo patients and healthy controls from India, including patients with a family history of the disease. Results Our results show significant alterations in the gut microbiome of vitiligo patients compared to healthy controls, affecting taxonomic and functional profiles as well as community structure. We observed a reduction in the abundance of several bacterial taxa commonly associated with a healthy gut microbiome and noted a decrease in the abundance of SCFA (Short Chain Fatty Acids) producing taxa in the vitiligo group. Observation of a higher abundance of genes linked to bacteria-mediated degradation of intestinal mucus suggested a potential compromise of the gut mucus barrier in vitiligo. Functional analysis also revealed a higher abundance of fatty acid and lipid metabolism-related genes in the vitiligo group. Combined analysis with data from a French cohort of vitiligo also led to the identification of common genera differentiating healthy and gut microbiome across populations. Conclusion Our observations, together with available data, strengthen the role of gut microbiome dysbiosis in symptom exacerbation and possibly pathogenesis in vitiligo. The reported microbiome changes also showed similarities with other autoimmune disorders, suggesting common gut microbiome-mediated mechanisms in autoimmune diseases. Further investigation can lead to the exploration of dietary interventions and probiotics for the management of these conditions. Supplementary Information The online version contains supplementary material available at 10.1186/s12866-024-03529-5.

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Evaluation of plasma zonulin level and its relationship with inflammatory cytokines in patients with vitiligo

Cited by 5 publications

References 18 publications

The Relationship between Serum Zonulin and Innate Immunity in Patients with Inflammatory Bowel Disease

The Relationship between Serum Zonulin and Innate Immunity in Patients with Inflammatory Bowel Disease

Assessment of Serum Zonulin Levels in Individuals Diagnosed With Chronic Spontaneous Urticaria

Insights into the gut microbiome of vitiligo patients from India

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