Background It has been proven that there is an increase in intestinal permeability in some autoimmune diseases. In our study, we purposed to assess intestinal permeability in vitiligo disease by looking at zonulin levels. At the same time, we aimed to examine the correlation of inflammatory cytokines and lipopolysaccharide (LPS) levels with zonulin. Methods Forty‐one patients and 41 healthy participants were involved in our study. Blood samples were taken from all patients and controls, and the levels of zonulin, tumor necrosis factor (TNF)‐α, interleukin (IL)‐6 and LPS were examined. Results The mean of zonulin in the patient group was found to be statistically higher than the control group (p < 0.05). A positive correlation was found between zonulin level and IL‐6, TNF‐α, and LPS levels (p < 0.05). TNF‐α and LPS levels in the vitiligo group were significantly higher than in the control group, but there was no such significance in terms of IL‐6 levels. Conclusion We think that serum zonulin level increases and intestinal permeability increases in vitiligo disease.

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Orf, a viral zoonotic disease, is caused by the orf virus, an epitheliotropic DNA virus from the parapoxvirus group. 1 It is caused by direct or indirect contact of decontaminated skin with infected animals. The incubation period is 3-15 days, and it usually progresses with one or more nodular lesions that appear on the dorsal surface of the fingers. The disease usually heals spontaneously after a course of 4-8 weeks. [2][3][4][5] Here, we present two pediatric patients with orf, unlike the classical localization, occurred in the burn area and progressed with multiple lesions. CASE REPORTS CASE 1A two-year-old male patient had a second degree burn due to hot water on the right side of his scalp, face and neck 10 days ago. In his dermatological examination, numerous red papules, plaques and vegetative masses were found on an erythematous and intensely edematous surface in the area extending from the right frontal region of the scalp to the occipital region (Figure 1A). Herpes simplex virus (HSV), Varicella-Zoster virus (VZV) polymerase chain reaction (PCR) and skin punch biopsy were taken from the lesions of the patient whose family was engaged in ovine breeding. Since eczema herpeticum was in the differential diagnosis and some of the lesions had a secondary infected appearance, acyclovir and ampcillin sulbactam treatments were started. As the HSV and VZV PCR results were negative, acyclovir treatment was discontinued, but ampicillin sulbactam treatment was continued for one week. Histopathological examination of the case re-

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