Evaluation of platelet indices as a useful marker in papillary thyroid carcinoma

Dinçel, Oğuzhan; Bayraktar, Cem

doi:10.4149/bll_2017_030

Cited by 32 publications

(41 citation statements)

References 17 publications

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“…It decreased to 7.60 fL (p = 0.005), so the postoperative MPV levels of patients and healthy controls were comparable. The same association was confirmed by other studies, which showed that MPV was significantly higher in the group of patients with thyroid cancer than in the benign group [25,26]. However, the prognostic role of MPV in this type of cancer has not yet been established.…”

Section: Evaluation Of Various Hematological Indices In Patients Withsupporting

confidence: 78%

The prognostic value of mean platelet volume in cancer patients

Masternak

Knap

Giannopoulos

2019

Acta Haematologica Polonica

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Basic hematological indices, such as platelets count (PLT), platelet distribution width (PDW), mean platelet volume (MPV), and plateletcrit (PCT), are readily accessible and commonly tested indicators. As platelets play a significant role in many physiological and patho- logical pathways, the abnormalities in these indices inference about irregularities within the organism, such as homeostatic disorders or inflammation. Recent studies revealed a significant impact of MPV on the course and prediction in different types of neoplasms. This review summarizes the most important studies on the impact of MPV levels on outcome and prognosis in different types of cancer conducted in recent years. MPV levels have a significant impact on the length of progression-free survival (PFS) and overall survival (OS) in many types of solid tumors, such as colorectal carcinoma, gastric cancer, pancreatic cancer, esophageal cancer, non-small cell lung cancer, breast cancer, and thyroid cancer. They also affect the prognosis in some lymphoproliferative diseases, such as diffuse large B-cell lymphoma, acute lymphoblastic leukemia, or primary and secondary myelofibrosis.

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Section: Evaluation Of Various Hematological Indices In Patients Withsupporting

confidence: 78%

The prognostic value of mean platelet volume in cancer patients

Masternak

Knap

Giannopoulos

2019

Acta Haematologica Polonica

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“…PCT, a factor that is calculated by PC and MPV, is now generally recognized to reflect platelet activity and the percentage of platelets in blood 19 . To date, PCT is only found to be higher in epithelial ovarian cancer, papillary thyroid carcinoma 14 , and pancreatic adenocarcinoma 46 . Our results firstly showed that PCT was increased in CRC patients.…”

Section: Discussionmentioning

confidence: 98%

“…New automated hematologic analyzers enabled to measure platelet count (PC) and platelets parameters with low cost. Parameters that are related to platelet are known as platelet indices, which mainly include platelet count (PC), mean platelet volume (MPV), platelet distribution width (PDW), and plateletcrit (PCT) 14 – 17 . MPV shows the average platelet volume in the blood, while PDW reflects the heterogeneity in platelet volume 18 .…”

Section: Introductionmentioning

confidence: 99%

Evaluation of platelet indices as diagnostic biomarkers for colorectal cancer

Zhu

Cao

et al. 2018

Sci Rep

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Altered platelet indices, including platelet count (PC), mean platelet volume (MPV), platelet distribution width (PDW), and plateletcrit (PCT), have been found in various cancer types. This study aimed to evaluate the role of platelet indices as potential biomarkers for the diagnosis of colorectal cancer (CRC), and to assess the association between platelet indices and CRC clinicopathological characteristics. The study included 783 subjects with CRC, 463 subjects with colorectal adenomas (CA), and 689 control subjects from June 2015 to October 2017. All participants’ clinicopathological characteristics were collected and analyzed. Here, we found that PC, MPV and PCT levels in CRC patients were significantly higher than those in CA patients and healthy participants (p < 0.001); however, PDW level in CRC patients was significantly higher than that in healthy participants while lower than that in CA patients. Receiver-operating characteristic (ROC) analysis indicated that combined detection of PCT and CEA appears to be a more effective marker to distinguish CRC patients from CA patients, with 70% sensitivity and 83% specificity. Among CRC patients, PC and PCT levels were associated with TNM stages and tumor size; MPV and PCT levels were associated with vascular invasion. Our findings suggest that altered PC, MPV and PCT levels might serve as potential biomarkers for the diagnosis and prognosis of CRC.

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“…The plateletcrit is determined by the formula platelet count times MPV divided by 10 4 , and the normal range for plateletcrit is 0.22−0.24% [23]. In a study of patients with papillary thyroid carcinoma (PTC), the plateletcrit ranges were 0.24±0.05 in the group with PTC and 0.17±0.02 in the control group, with a significant difference between the two groups (P < 0.01) [24]. In the present study, the plateletcrit range was 0.0870-0.3802% and the cut-off value was 0.2755% according to maximally selected rank statistics using R (maxstat package) software.…”

Section: Discussionmentioning

confidence: 99%

Preoperative plateletcrit is a Prognostic Biomarker for Survival in Patients with Non-Small Cell Lung Cancer

Hur¹,

Lee²,

Chang³

et al. 2020

J. Cancer

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Objectives: Several factors associated with the prognosis of patients with NSCLC have been reported in the literature; however, most of these factors cannot be examined preoperatively. In this study, the clinical utility of platelet parameters in patients with NSCLC who underwent curative resection was evaluated. Materials and Methods: A retrospective study on patients with NSCLC who underwent curative resection from July 2006 to September 2016 was conducted. The Cox proportional hazard regression model was applied to evaluate the variables that demonstrated effects on disease-free and overall survival (DFS and OS). Results: A total of 116 patients with NSCLC were analyzed. There were 15 patients with plateletcrit greater than 0.2755%, and 101 patients whose plateletcrit was 0.2755% or lower. Multivariate analysis identified plateletcrit higher than 0.2755% (hazard ratio [HR] = 4.18, 95% confidence interval [CI] = 1.54-11.34, P =0.004), patient age of 65 years or more (HR = 4.02, 95% CI = 1.67−9.66, P = 0.001), and stage II or IIIA disease (HR = 2.95, 95% CI = 1.26−6.87, P = 0.012) as independent factors for OS that predicted a poor prognosis. Multivariate analysis identified plateletcrit higher than 0.2755% (HR = 4.07, 95% CI = 1.52−10.94, P = 0.005), stage II or IIIA disease (HR = 5.38, 95% CI = 2.71−10.66, P < 0.001) and non-adenocarcinoma (HR = 1.92, 95% CI = 1.02-3.59, P = 0.040) as independent prognostic factors for DFS that predicted a poor prognosis. Conclusion: Our results suggest a potential role of preoperative plateletcrit as an independent prognostic marker for patients with resectable NSCLC.

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Evaluation of platelet indices as a useful marker in papillary thyroid carcinoma

Cited by 32 publications

References 17 publications

The prognostic value of mean platelet volume in cancer patients

The prognostic value of mean platelet volume in cancer patients

Evaluation of platelet indices as diagnostic biomarkers for colorectal cancer

Preoperative plateletcrit is a Prognostic Biomarker for Survival in Patients with Non-Small Cell Lung Cancer

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