Evaluation of point‐of‐care haemoglobin measuring devices: a comparison of Radical‐7™ pulse co‐oximetry, HemoCue^® and laboratory haemoglobin measurements in obstetric patients*

Abstract

SummaryWe prospectively compared two point-of-care haemoglobin concentration measuring devices with laboratory measurements to determine their accuracy in women undergoing caesarean section delivery. The two devices were the Masimo Rainbow SET Ò Radical -7 TM pulse co-oximeter and the HemoCue Ò HB 201+, which is a cuvette-type system that uses photometry. Co-oximeter readings and HemoCue measurements were taken before and after surgery, and compared with laboratory measurements of haemoglobin concentration taken at the same time. We analysed data from 137 patients using Bland-Altman plots. Limits of agreement for co-oximeter readings were )4.20 to 2.02 g.dl )1 and for HemoCue were )1.49 to 1.48 g.dl )1 . The bias (mean difference) for the co-oximeter was )1.09 g.dl )1 (95% CI )1.28 to )0.91) and for the HemoCue was )0.001 g.dl )1 (95% CI )0.089 to 0.088). Overall, 110 ⁄ 274 (40%) co-oximeter readings were within 1 g.dl

Noninvasive Assessment of Excessive Erythrocytosis as a Screening Method for Chronic Mountain Sickness at High Altitude

“…In our study, we found that Pronto-7 had an overall bias of -0.2 g/dL, when compared to a laboratory hemoglobin analyzer, which is well within the limits of acceptable difference of 1.0 g/dL (Gehring et al, 2002. Adam et al, 2012. Skelton et al, 2013.…”

3D printed auto-mixing chip enables rapid smartphone diagnosis of anemia

“…48 Several portable devices for anemia diagnosis have been developed, 49,50 such as HemoCue-B Hemoglobin, 51 STAT-Site V R MHgb, 52 Rainbow V R signal extraction technology (SET), and SpectOLight TM Occlusion. 53 However, few of these tools are well-suited for transferring to low-resource areas, due to their costs and sophisticated designs that require professional operation. Simple and disposable platforms have recently been developed to test blood Hgb levels, 37,54,55 including the WHO Hb color scale (HbCS) test, 56 but these platforms require fabrication facilities in scientific laboratories or skilled technicians for mass production and technology transfer, thereby offering limited adaptability for establishing study capacity in rural areas or low-income countries.…”

Direct Analysis of Dried Blood Spot Samples

“…Alternatively, if sufficient sample volume is available, automated analysers are available that can measure haematocrit (from wet blood samples) in isolation (typically using electrical impedance). Similarly, point-of-care testing systems are available that can measure the haemoglobin in blood, which enables the calculation of HCT (88) . Knowing the HCT value of a sample means it can be checked against the accepted HCT range, defined during method validation.…”