Evaluation of poly(ethylene oxide)–poly(propylene oxide)–poly(ethylene oxide) (PEO–PPO–PEO) gels as a release vehicle for percutaneous fentanyl

Liaw, Jiahorng; Lin, Yen Chao

doi:10.1016/s0168-3659(00)00268-6

Cited by 78 publications

(67 citation statements)

References 22 publications

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“…11 By measuring the intensity ratios of the first to the third vibrational bands of pyrene, it was found that the I 1 /I 3 peak height ratio decreased above 0.1% w/w of only block copolymers (Figure 1, triangles). The magnitude of I 1 /I 3 in the high concentration range (here 1.55) is somewhat higher than that for pyrene in a toluene solution (1.04) but significantly lower than that in water (1.75).…”

Section: Resultsmentioning

confidence: 99%

“…10 This PEO-type carrier of block copolymer not only leads to enhanced passive transport but also avoids liver degradation. In our previous study, 11 we found through pharmacokinetic data, that using a PEO-PPO-PEO copolymer micelle-fentanyl patch in vivo prolonged the half-life (t 1/2 ) of fentanyl in the blood stream up to five times. Thus, this type of copolymer micelle carrier appears to have the potential to act as a topical drug delivery carrier since it prevents serum/protein interaction and the micelle carrier has good stability characteristics.…”

Section: Introductionmentioning

confidence: 93%

“…11 The different weighed amounts of copolymer were added to water with gentle mixing. Different concentrations of plasmid were gently mixed with PEO-PPO-PEO polymeric micelles in a vial for 2 h.…”

Section: Plasmidmentioning

confidence: 99%

“…11 The fluorescence emission spectrum of pyrene in the PEO-PPO-PEO copolymer micelle solutions was measured from 350 to 500 nm using a fixed excitation wavelength of 339 nm with a constant pyrene concentration of 6 × 10 −7 m. The PEO-PPO-PEO block copolymer varied from 0.001% to 20% (w/w) with or without 0.08 g/ l of plasmid. The spectral data were acquired using a Hitachi F-4500 fluorescence spectrophotometer (Hitachi, Tokyo, Japan).…”

Section: Plasmidmentioning

confidence: 99%

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In vivo gene delivery into ocular tissues by eye drops of poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide) (PEO-PPO-PEO) polymeric micelles

2001

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The primary objective of this study was to investigate the feasibility of using PEO-PPO-PEO non-ionic copolymeric micelles as a carrier for eye-drop gene delivery of plasmid DNA with lacZ gene in vivo. Using pyrene fluorescence probe methods, zeta potential, and dynamic light scattering test (DLS), the ability of micelle formation of these block copolymers with plasmid was studied. Gene expressions were visualized by both the quality of enzymatic color reaction using X-gal staining and by the quantification of the substrate chlorophenol red galactopyranoside (CPRG) in enucleated eyes on day 2 after gene transfer. In addition, microscopy to identify the types of cell showing uptake and expression of the transferred gene was used. We found that the block polymeric micelles were formed above 0.1% (w/v) of block copolymer with a size of 160 nm and a zeta potential

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 93%

Section: Plasmidmentioning

confidence: 99%

Section: Plasmidmentioning

confidence: 99%

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In vivo gene delivery into ocular tissues by eye drops of poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide) (PEO-PPO-PEO) polymeric micelles

2001

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“…Studies on PEO-PPO-based polymeric micelles for transdermal drug delivery have been widely carried out with Poloxamer 407 (Pluronic F127) and these studies mostly focused on small drug molecules in order of anti-inflammatory [8][9][10][11][12][13][14][15][16][17][18][19], analgesic [20], local anesthetic [21] and cardiac effectiveness [19,[22][23][24] and rarely focused on big molecules such as arginine vasopressin (AVP) and insulin [25,26].…”

Section: Peo-ppo Based Copolymers In Transdermal Drug Deliverymentioning

confidence: 99%

Poly(ethylene oxide)–Poly(propylene oxide)-Based Copolymers for Transdermal Drug Delivery: An Overview

Yapar¹,

Ýnal²

2013

Trop. J. Pharm Res

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Polymers Exhibiting Lower Critical Solution Temperatures as a Route to Thermoreversible Gelators for Healthcare

Cook

Haddow

Kirton

et al. 2020

Adv Funct Materials

144

113

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The ability to trigger changes to material properties with external stimuli, so‐called “smart” behavior, has enabled novel technologies for a wide range of healthcare applications. Response to small changes in temperature is particularly attractive, where material transformations may be triggered by contact with the human body. Thermoreversible gelators are materials where warming triggers reversible phase change from low viscosity polymer solution to a gel state. These systems can be generated by the exploitation of macromolecules with lower critical solution temperatures included in their architectures. The resultant materials are attractive for topical and mucosal drug delivery, as well as for injectables. In addition, the materials are attractive for tissue engineering and 3D printing. The fundamental science underpinning these systems is described, along with progress in each class of material and their applications. Significant opportunities exist in the fundamental understanding of how polymer chemistry and nanoscience describe the performance of these systems and guide the rational design of novel systems. Furthermore, barriers to translating technologies must be addressed, for example, rigorous toxicological evaluation is rarely conducted. As such, applications remain tied to narrow fields, and advancements will be made where the existing knowledge in these areas may be applied to novel problems of science.

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Evaluation of poly(ethylene oxide)–poly(propylene oxide)–poly(ethylene oxide) (PEO–PPO–PEO) gels as a release vehicle for percutaneous fentanyl

Cited by 78 publications

References 22 publications

In vivo gene delivery into ocular tissues by eye drops of poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide) (PEO-PPO-PEO) polymeric micelles

In vivo gene delivery into ocular tissues by eye drops of poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide) (PEO-PPO-PEO) polymeric micelles

Poly(ethylene oxide)–Poly(propylene oxide)-Based Copolymers for Transdermal Drug Delivery: An Overview

Polymers Exhibiting Lower Critical Solution Temperatures as a Route to Thermoreversible Gelators for Healthcare

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