Poly(ethylene oxide)–Poly(propylene oxide)-Based Copolymers for Transdermal Drug Delivery: An Overview

Yapar, E Algin; Ýnal, Ö

doi:10.4314/tjpr.v11i5.20

Cited by 18 publications

(21 citation statements)

References 55 publications

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“…Their unique properties, such as high water content, biocompatibility and flexibility, give rise to potential applications in topical or transdermal drug delivery. Following the marketing of the primary wound dressings based on polyethylene oxide (PEO), e.g., Vigilon ® , this non-ionic, synthetic, hydrophilic polymer has also gained interest from researchers as a suitable platform to transport drugs topically or transdermally [ 1 , 2 , 3 ]. PEO is an FDA-approved material and it is ideal for topical and transdermal drug delivery due to little to no immunogenicity, absence of residues, sediments, or vaporous elements when applied onto skin [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

Effect of Crosslinking Agent Concentration on the Properties of Unmedicated Hydrogels

2015

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Novel polyethylene oxide (PEO) hydrogel films were synthesized via UV crosslinking with varying concentrations of pentaerythritol tetra-acrylate (PETRA) as crosslinking agent. The aim was to study the effects of the crosslinking agent on the material properties of hydrogel films intended for dermatological applications. Fabricated film samples were characterized using swelling studies, scanning electron microscopy, tensile testing and rheometry. Films showed rapid swelling and high elasticity. The increase of PETRA concentration resulted in significant increase in the gel fraction and crosslinking density (ρc), while causing a significant decrease in the equilibrium water content (EWC), average molecular weight between crosslinks (trueM¯normalc), and mesh size (ζ) of films. From the scanning electron microscopy, cross-linked PEO hydrogel network appeared as cross-linked mesh-like structure with interconnected micropores. Rheological studies showed PEO films required a minimum of 2.5% w/w PETRA to form stable viscoelastic solid gels. Preliminary studies concluded that a minimum of 2.5% w/w PETRA is required to yield films with desirable properties for skin application.

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Section: Introductionmentioning

confidence: 99%

Effect of Crosslinking Agent Concentration on the Properties of Unmedicated Hydrogels

2015

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“…The borneol could increase transportation of geniposide across the human nasal epithelial cell [ 18 , 19 ]. Poloxamer was temperature-triggered, nontoxic, nonirritating and non-sensitizing polymer [ 20 – 22 ]. Poloxamer and hydroxypropyl methylcellulose have been used for the in situ gel [ 23 – 25 ].…”

Section: Introductionmentioning

confidence: 99%

A mucoadhesive, thermoreversible in situ nasal gel of geniposide for neurodegenerative diseases

et al. 2017

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Neurodegenerative diseases are becoming prevalent as the population ages. Geniposide could inhibit oxidative stress, reduce apoptosis, protect neuron, and has been used for therapy of the neurodegenerative diseases. The bioavailability of geniposide by nasal route is greater than that by oral administration. However, mucociliary clearance is a rate-limiting factor for nasal route administration. The objective of this study was to develop and evaluate a mucoadhesive, thermoreversible in situ nasal gel of geniposide. The poloxamers (P407, P188) and the hydroxypropyl methylcellulose were used as thermoreversible and mucoadhesive polymers, respectively. Borneol was used as a permeation enhancer. The hydrogel was prepared with the cold method and optimized by the response surface methodology-central composite design. Gelation temperature, pH, clarity, gel strength, mucoadhesive strength, in vitro and ex vivo release kinetics of formulations were evaluated. The optimized amounts of poloxamer407 (P407), poloxamer188 (P188) and hydroxypropyl methylcellulose were determined to be 19.4–20.5%, 1.1–4.0% and 0.3–0.6% respectively. The second-order polynomial equation in terms of actual factors indicated a satisfactory correlation between the independent variables and the response (R2 = 0.9760). An ANOVA of the empirical second-order polynomial model indicated the model was significant (P<0.01). P407, P188, P407×P188, P4072 and P1882 were significant model terms. The effects of P407 on gelation temperature were greater than those of other independent variables. The pH values of all the formulations were found to be within 6.3–6.5 which was in the nasal physiological pH range 4.5–6.5. The drug content, gel strength, mucoadhesive strength of the optimized formulations were 97–101%, 25–50 sec and 4000–6000 dyn/cm2 respectively. The in vitro release kinetics of cumulative release of geniposide was fitted to the zero-order model. The ex vivo cumulative release kinetics of geniposide was fitted to the Weibull model. This study concludes that the release of geniposide is controlled by gel corrosion, and that the permeation of geniposide is time-dependent. The more residence time, mucoadhesive, thermoreversible in situ nasal gel of geniposide for neurodegenerative diseases is of compliance and potential application.

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“…The percutaneous behavior could greatly be enhanced with a microneedle and an ultrasound. In this regard, poloxamer 407, which is a thermosensitive amphiphilic block copolymer, has found extensive applications as a drug carrier matrix in the development of transdermal delivery systems [152].…”

Section: Hydrogel Based Transdermal Therapymentioning

confidence: 99%

Functionalized Textile Based Therapy for the Treatment of Atopic Dermatitis

2017

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Atopic dermatitis (AD) is a common chronic inflammatory skin condition characterized by intense puritus and skin dryness. The pathogenesis for AD has not been fully understood to date. Complementary therapies are very popular as effective treatment for AD among clinical practitioners. This study presents a comprehensive review of published works associated with textiles-based complementary therapies for AD treatment such as wet-wrap dressing, functionalized textiles, and the application of hydrogel techniques in the textile industry to provide a better understanding of the development and design of new textiles-based transdermal therapies.

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Poly(ethylene oxide)–Poly(propylene oxide)-Based Copolymers for Transdermal Drug Delivery: An Overview

Abstract: Amphiphilic poly (ethylene

Cited by 18 publications

References 55 publications

Effect of Crosslinking Agent Concentration on the Properties of Unmedicated Hydrogels

Effect of Crosslinking Agent Concentration on the Properties of Unmedicated Hydrogels

A mucoadhesive, thermoreversible in situ nasal gel of geniposide for neurodegenerative diseases

Functionalized Textile Based Therapy for the Treatment of Atopic Dermatitis

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