Evaluation of porous gradient hydroxyapatite/zirconia composites for repair of lumbar vertebra defect in dogs

Shao, Rongxue; Quan, Renfu; Huang, Xiaolong; Wang, Tuo; Xie, Shangju; Gao, Huanhuan; Wei, Xicheng; Yang, Disheng

doi:10.1177/0885328215627616

Cited by 8 publications

(18 citation statements)

References 32 publications

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“…87,128,158 Researchers have also investigated combinations of these materials to produce composites such as SF/ceramic, 91 HAp/polymer, 49,53,140 and metal/ceramic composites. 54 Often, composites are produced to improve a particular aspect of a bone graft.…”

Section: Discussionmentioning

confidence: 99%

A novel classification of bone graft materials

2022

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Over the past few decades, the field of biomaterials concerning bone tissue engineering has gained a significant amount of interest. This has led to new biomaterials to be used as bone substitute materials. Despite the rapid increase in the types and forms of bone substitutes, a comprehensive classification encompassing all types of bone graft materials that have so far been developed and evaluated is lacking. Therefore, this review aims to integrate and bring together the published data on bone substitutes within the last 5 years and produce a novel classification that would provide bone material researchers with a better understanding of what materials have so far been used and evaluated and the areas, where research is lacking and deserves more attention. The literature available in all major databases was obtained and filtered using an elimination criterion to extract all the articles related to studies that tested bone substitute materials in nonclinical and clinical trials over the last 5 years. The review article would provide bone material researchers with an insight into the materials that have been evaluated for bone tissue engineering applications and identify future perspectives for bone graft material research.

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Section: Discussionmentioning

confidence: 99%

A novel classification of bone graft materials

2022

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“…Moreover, the PGHC demonstrated excellent biocompatibility and surface roughness. A porous structure of this type was found to significantly increase the connective surface area between the graft materials and the new bone, which can allow the materials to form a strong connection with the host bone (Shao et al, ).…”

Section: Discussionmentioning

confidence: 99%

“…Our previous study indicated that the cytotoxicity of the HA/ZrO 2 composite is low and acceptable (Quan et al, ). A biomechanical assay showed that the ultimate compressive strength of PGHC was significantly greater than that of the porous HA material and lower than that of porous ZrO 2 materials (Shao et al, ). BMSCs are capable of osteogenic cell transformation and self‐renewal (Nakamura et al, ).…”

Section: Discussionmentioning

confidence: 99%

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Effects of a bone graft substitute consisting of porous gradient HA/ZrO₂and gelatin/chitosan slow‐release hydrogel containing BMP‐2 and BMSCs on lumbar vertebral defect repair in rhesus monkey

Shao

Quan

Wang

et al. 2017

J Tissue Eng Regen Med

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Dense biomaterial plays an important role in bone replacement. However, it fails to induce bone cell migration into graft material. In the present study, a novel bone graft substitute (BGS) consisting of porous gradient hydroxyapatite/zirconia composite (PGHC) and gelatin/chitosan slow-release hydrogel containing bone morphogenetic protein 2 and bone mesenchymal stem cells was designed and prepared to repair lumbar vertebral defects. The morphological characteristics of the BGS evaluated by a scanning electron microscope showed that it had a three-dimensional network structure with uniformly distributed chitosan microspheres on the surfaces of the graft material and the interior of the pores. Then, BGS (Group A), PGHC (Group B), or autologous bone (Group C) was implanted into lumbar vertebral body defects in a total of 24 healthy rhesus monkeys. After 8 and 16 weeks, anteroposterior and lateral radiographs of the lumbar spine, microcomputed tomography, histomorphometry, biomechanical testing, and biochemical testing for bone matrix markers, including Type I collagen, osteocalcin, osteopontin, basic fibroblast growth factor, alkaline phosphatase, and vascular endothelial growth factor, were performed to examine the reparative efficacy of the BGS and PGHC. The BGS displayed excellent ability to repair the lumbar vertebral defect in rhesus monkeys. Radiography, microcomputed tomography scanning, and histomorphological characterization showed that the newly formed bone volume in the interior of the pores in the BGS was significantly higher than in the PGHC. The results of biomechanical testing indicated that the vertebral body compression strength of the PGHC implant was lower than the other implants. Reverse-transcription polymerase chain reaction and western blot analyses showed that the expression of bone-related proteins in the BGS implant was significantly higher than in the PGHC implant. The BGS displayed reparative effects similar to autologous bone. Therefore, BGS use in vertebral bone defect repair appears promising.

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“…These scaffolds can promote bone repair and support bone to grow into the scaffold pores. 78 Zirconia/HA scaffolds with different zirconia: HA ratios have also been fabricated, optimized, and extensively characterized. The porosity of a zirconia/HA scaffold can be adjusted from approximately 70% to 90%, and the compressive strength of the scaffold increases from 2.5 to 13.8 MPa when the zirconia content increased from 50 to 100 wt%.…”

Section: Osteogenic Scaffolds For Hard Tissue Engineeringmentioning

confidence: 99%

Zirconia-Based Biomaterials for Hard Tissue Reconstruction

Tosiriwatanapong

Singhatanadgit

2018

Bone�Tissue�Regen�Insights

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Implantable biomaterials are increasingly important in the practice of modern medicine, including fixative, replacement, and regeneration therapies, for reconstruction of hard tissues in patients with pathologic osseous and dental conditions. A number of newly developed advanced biomaterials have been introduced as promising candidates for tissue reconstruction. Among these, zirconia-based biomaterials have gained attention as a biomaterial for hard tissue reconstruction due to superior mechanical properties and good chemical and biological compatibilities. This review summarizes the types of zirconia, advantages of zirconia-based biomaterials for hard tissue reconstruction including bone and dental tissues, responses of tissue and cells to zirconia, and surface modifications for enhanced bioactivity of zirconia. Current and future applications of zirconia-based biomaterials for bone and dental reconstruction, ie, medical implanted devices, dental prostheses, and biocompatible osteogenic scaffolds, are also discussed.

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Evaluation of porous gradient hydroxyapatite/zirconia composites for repair of lumbar vertebra defect in dogs

Abstract: New porous gradient hydroxyapatite/zirconia composites can promote the repair of bony defect, and induce bone tissue to ingrow into the pores, which may be applied widely to the treatment of bony defect in the future.

Cited by 8 publications

References 32 publications

A novel classification of bone graft materials

A novel classification of bone graft materials

Effects of a bone graft substitute consisting of porous gradient HA/ZrO₂and gelatin/chitosan slow‐release hydrogel containing BMP‐2 and BMSCs on lumbar vertebral defect repair in rhesus monkey

Zirconia-Based Biomaterials for Hard Tissue Reconstruction

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Evaluation of porous gradient hydroxyapatite/zirconia composites for repair of lumbar vertebra defect in dogs

Abstract: New porous gradient hydroxyapatite/zirconia composites can promote the repair of bony defect, and induce bone tissue to ingrow into the pores, which may be applied widely to the treatment of bony defect in the future.

Cited by 8 publications

References 32 publications

A novel classification of bone graft materials

A novel classification of bone graft materials

Effects of a bone graft substitute consisting of porous gradient HA/ZrO2and gelatin/chitosan slow‐release hydrogel containing BMP‐2 and BMSCs on lumbar vertebral defect repair in rhesus monkey

Zirconia-Based Biomaterials for Hard Tissue Reconstruction

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Effects of a bone graft substitute consisting of porous gradient HA/ZrO₂and gelatin/chitosan slow‐release hydrogel containing BMP‐2 and BMSCs on lumbar vertebral defect repair in rhesus monkey