Evaluation of Possible Genotoxic Mechanisms for Acrylonitrile Tumorigenicity

Whysner, John; Ross, Peter M.; Conaway, C. Clifford; Verna, Lynne; Williams, Gary M.

doi:10.1006/rtph.1998.1204

Cited by 30 publications

(47 citation statements)

References 85 publications

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“…No DNA adducts of acrylonitrile or its metabolites have been identified in rat brain (31). However, recently, increased levels of 8-oxodeoxyguanosine have been found in rats at doses of acrylonitrile similar to those that produced increases in brain tumors (32), and increased levels of 8-hydroxy-2'deoxyguanosine have been found in acrylonitrile-treated Syrian hamster embryo cells in parallel with a dose-dependent increase in morphologically transformed Syrian hamster embryo cell colonies (33).…”

Section: Discussionmentioning

confidence: 99%

Reconciling animal and human data in a cancer risk assessment of acrylonitrile

Schulz¹,

Hertz‐Picciotto²,

Todd³

et al. 2001

Scand J Work Environ Health

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Section: Discussionmentioning

confidence: 99%

Reconciling animal and human data in a cancer risk assessment of acrylonitrile

Schulz¹,

Hertz‐Picciotto²,

Todd³

et al. 2001

Scand J Work Environ Health

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“…Studies in rats showed that brain tumors can be induced by various carcinogenic substances (1,2), but observational studies in human showed no definitive association between occupational or environmental exposures and brain tumor incidence (3,4). These negative findings may reflect the difficulty in characterizing exposure, particularly as a doseresponse relationship.…”

Section: Introductionmentioning

confidence: 99%

Genetic Polymorphisms of GlutathioneS-Transferases and the Risk of Adult Brain Tumors: A Meta-analysis

Lai

Crevier

Thabane

2005

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Background: Studies investigating the association between genetic polymorphisms of glutathione S-transferases (GST) and risk of adult brain tumors have reported conflicting results. The rationale of this meta-analysis was to determine whether GST variants increase the susceptibility of adult brain tumors by pooling data. Methods: Two investigators independently searched the HuGENet database, MEDLINE, EMBASE, conference articles, and manually reviewed bibliographies of retrieved articles. Papers were included if they were observational studies investigating the influence of GSTM1, GSTT1, GSTP1 I105V, or GSTP1 A114V on the development of adult brain cancers. Potential sources of heterogeneity between studies were explored in a meta-regression. Results: We identified eight eligible studies, which included 1,630 cases of glioma, 245 cases of meningioma, and 7,151 controls. Using the random effects model, there was no

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“…This is the ¢rst report of B. subtilis having the ability to metabolize AN. Mammalian cells are able to convert AN into cyanide and CEO utilizing cytochrome P450 enzymes [9]. Chemical analyses indicated that cyanide was produced, but in only micromolar levels (Fig.…”

Section: Discussionmentioning

confidence: 99%

“…Animal cells are known to metabolize AN to cyanoethylene oxide and to cyanide [9]. B. subtilis, however, has not been reported to possess the ability to metabolize AN.…”

Section: B Subtilis Converts An To Cyanide and Cyanoethylene Oxidementioning

confidence: 99%

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Acrylonitrile induces autolysis Bacillus subtilis

Reyes

2000

FEMS Microbiology Letters

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Acrylonitrile (AN) is an industrial chemical used in the manufacture of plastics and other polymers. AN has been reported to be an acute toxin and is a known carcinogen in rodents. When AN was mixed with suspensions of Bacillus subtilis, the bacteria began autolysis. It was determined that AN is partially converted to cyanide, a strong protonophore in B. subtilis. Autolytic enzymes in B. subtilis become active when the protonmotive force is dissipated. The amount of cyanide produced from AN, however, was not enough to promote autolysis in exponential B. subtilis. This is the first report showing that AN may induce autolytic reactions in bacteria. It is suggested the autolysis of B. subtilis may be useful in the environmental monitoring of AN. In addition, the metabolism of AN by bacilli may be useful in bioremediation. ß

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Evaluation of Possible Genotoxic Mechanisms for Acrylonitrile Tumorigenicity

Cited by 30 publications

References 85 publications

Reconciling animal and human data in a cancer risk assessment of acrylonitrile

Reconciling animal and human data in a cancer risk assessment of acrylonitrile

Genetic Polymorphisms of GlutathioneS-Transferases and the Risk of Adult Brain Tumors: A Meta-analysis

Acrylonitrile induces autolysis Bacillus subtilis

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