Evaluation of post-surgical healing in rats using a topical preparation based on extract of Musa sapientum L., Musaceae, epicarp

Abstract

Abstract:Considering that oral preparations made with peel green bananas (e.g. flour and extracts) demonstrated healing effects on mucous membranes and skin, this study evaluated the healing and the antimicrobial property of a topical preparation based on extract of Musa sapientum L., Musaceae, (apple banana) in surgically induced wounds in the skin of male Wistar rats, 100 g. The extract was obtained by decoction, the presence of tannins was detected by phytochemical screening and 10% of the extract was incorporated into the carbopol gel (CMS gel). The processes of healing and bacterial isolation were evaluated in the following experimental groups: control (no treatment), treatment with placebo or with the CMS gel. The healing of surgical wounds treated with the CMS gel was faster when compared with the control and placebo groups and the treatment with CMS gel also inhibited the growth of pyogenic bacteria and enterobacteria in the wounds. The results indicate that the extract of Musa sapientum epicarp has healing and antimicrobial properties (in vivo), probably, due to tannins.

Chitosan Associated with the Extract of Unripe Banana Peel for Potential Wound Dressing Application

“…Although FTIR analysis was not conclusive, it showed strong evidences of the presence of tannins in unripe banana peel and membranes. Tannins show antimicrobial activity, which plays an important role in wound healing applications [9][10][11][12][13]. We recently demonstrated the efficiency of chitosan membranes associated with unripe banana peel extracts on the growth inhibition of Staphylococcus aureus and Escherichia coli, most common bacteria found in skin wounds [9].…”

“…It is antioxidant and antimicrobial (bacterial, fungal, and yeast activities) and demonstrates higher concentration of phenolic compounds and mineral content [9][10][11]. The healing and antimicrobial properties of banana peel are associated with the presence of tannin, which are found in higher concentration in the unripe banana peel [12,13]. Thus, association of chitosan and unripe banana peel might be a great alternative of a low-cost biomaterial for wound dressing application.…”

Banana Peel: Characteristics and Consideration of Its Extract for Use in Meat Products Preservation: A Review

“…The antibacterial activity of most of the banana peel varieties is correlated with the tannins present, which are believed to have protein precipitating capacity credited to the astringent action which ultimately affects bacterial peptidoglycan. 64 Several authors have supported the fact of using BP for the production of various natural dyes that can protect cotton fabrics against harmful bacterial effects. 65 The banana peel (aqueous extract) has a persuasive antibacterial effect.…”

“…Despite a limited number of studies regarding the antimicrobial potential of BP, particularly in vitro , several authors reported the role of phenolic compounds in inhibiting the growth and development of spoilage and pathogenic microorganisms through different mechanisms. The antibacterial activity of most of the banana peel varieties is correlated with the tannins present, which are believed to have protein precipitating capacity credited to the astringent action which ultimately affects bacterial peptidoglycan . Several authors have supported the fact of using BP for the production of various natural dyes that can protect cotton fabrics against harmful bacterial effects .…”

Antibacterial Activity Extract of Leaves of Kaffir Lime (Citrus hystrix DC) Againts of Staphylococcus aureus Bacteria

“…Apabila dinding sel rusak maka hal tersebut akan mengganggu kegiatan dalam sel sehingga sel tersebut juga akan rusak dan mati. Jadi, tanin berfungsi untuk merusak dinding sel bakteri Staphylococcus aureus (Dalimartha, 2000;Kumar et al, 2012;Min et al, 2008;Lino et al, 2011). Tanin merupakan senyawa fenol bekerja dengan cara menghambat pertumbuhan bakteri dengan melakukan denaturasi protein, sehingga permeabilitas bakteri meningkat.…”