Evaluation of Potential Antidepressant-Like Activity of Chalcone-1203 in Various Murine Experimental Depressant Models

Abstract

Two classic animal behavior despair tests-the forced swimming test (FST) and the tail suspension test (TST) were used to evaluate antidepressant-like activity of a new chalcone compound, chalcone-1203 in mice. It was observed that chalcone-1203 at dose of 1, 5, and 10 mg/kg significantly reduced the immobility time in the FST and TST in mice 30 min after treatment. In addition, chalcone-1203 was found to exhibit significant oral activity in the FST in mice. It also produced a reduction in the ambulation in the open-field test in mice not previously habituated to the arena, but no effect in the locomotor activity in mice previously habituated to the open-field. The main monoamine neurotransmitters and their metabolites in mouse brain regions were also simultaneously determined by HPLC-ECD. It was found that chalcone-1203 significantly increased the concentrations of the main neurotransmitters 5-HT and NE in the hippocampus, hypothalamus and cortex. Chalcone-1203 also significantly reduced the ratio of 5-HIAA/5-HT in the hippocampus and cortex, shown down 5-HT metabolism compared with mice treated with stress vehicle. In conclusion, chalcone-1203 produced significant antidepressant-like activity, and the mechanism of action may be due to increased 5-HT and NE in the mouse hippocampus and cortex.

Antidepressant-like effects and mechanisms of flavonoids and related analogues

“…Chalcone-1203 significantly increased the concentrations of 5-HT and NE in the hippocampus, hypothalamus and cortex and significantly lowered the ratio of 5-HIAA/5-HT in the hippocampus and cortex, slowing down 5-HT metabolism compared with stressed mice treated with vehicle. The mechanism of action of chalcone-1203 may be because of increased 5-HT and NE in the mouse hippocampus and cortex [102].…”

Andrographolide Exerts Significant Antidepressant-Like Effects Involving the Hippocampal BDNF System in Mice

“…Briefly, naive mice received a single injection of vehicle/fluoxetine (20 mg/kg)/Andro (10, 20, 50, or 100 mg/kg). After 30 minutes, the FST, TST, or OFT was performed (Farzin and Mansouri, 2006; Wang et al, 2008; Guan et al, 2014). Separate groups of mice were used for the 3 tests (n = 10).…”

Design, synthesis, and anticonvulsant effects evaluation of nonimidazole histamine H3receptor antagonists/inverse agonists containing triazole moiety

“…Supported by the above results, in this work, we designed and synthesised some novel H 3 R antagonists/inverse agonists by hybriding the H 3 R pharmacophore (aliphatic amine with propyloxy chain) with the 1,2,4-triazole, the latter have been identified as an important and effective anticonvulsive fragment in recent years (Figure 1, II and III) [33][34][35][36][37] . According to Quan's reports, the 1,2,4-triazole derivatives were likely to have several mechanisms of action such as inhibiting voltage-gated sodium ions channel and modulating GABAergic activity [38][39][40] . And a group of Plech illustrated the anticonvulsive effects of 4-alkyl-5-aryl-1,2,4-triazole-3-thione derivatives and suggested that the influence on the voltage-gated Na þ channels was involved in them at least 41,42 .…”