Evaluation of predictive formulae for glomerular filtration rate for carboplatin dosing in gynecological malignancies

Lemos, Mário L de; Hsieh, Teresa; Hamata, Linda; Levin, Adeera; Swenerton, K.; Djurdjev, Ognjenka; Vu, Thanh H.; Hu, F.; Conklin, James; Taylor, S. Martin

doi:10.1016/j.ygyno.2006.06.024

Cited by 47 publications

(51 citation statements)

References 48 publications

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“…The Wright and CKD-EPI formulae had good accuracy (i.e., 0.69 and 0.63, respectively), with statistical significance, which was not the case for MDRD and CG formulae. As this group of patients has a high risk of overdosing and toxicity, they need the most accurate formula because they might even be at risk of not receiving the CP, even under medical recommendation [15]. …”

Section: Discussionmentioning

confidence: 99%

Carboplatin Dosing Accuracy by Estimation of Glomerular Filtration versus Creatinuria in Cancer Patients

2018

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Background: The glomerular filtration rate (GFR) is essential for calculating the dose and the monitoring of carboplatin. Although GFR measurement (mGFR) by external markers is ideal, in most cases these are not employed; the most used method is GFR estimation (eGFR) by formulae, hence the need to identify the formula with the best performance. Methods: Patients admitted between 2011 and 2017 and diagnosed with ovarian, endometrial, lung, esophageal, or testicular cancer were assessed retrospectively. The accuracy of the carboplatin dose calculated by creatinine concordance and by the Cockroft-Gault (CG), CKD-EPI, MDRD, Wright, and Jelliffe formulae was assessed using the intraclass correlation coefficient. Results: Fifty-six medical histories were analyzed. The best accuracy was observed between the Wright formula (i.e., 0.71) and the dose calculated based on the 24-h creatinine clearance. Stratification by CKD was made in depurations < 60 mL/min, where the Jelliffe value was excellent (i.e., 0.75). In depurations ≥60 mL/min, CKD-EPI was the best formula, with an accuracy of 0.65. CG was the formula with the worst performance in calculating the dose and glomerular filtration, losing its usefulness with very low filtrations. Conclusions: GFR formulae and calculation of the carboplatin dose have good accuracy with the GFR obtained based on the 24-h creatinine clearance, with the Wright formula being the one with best performance and CG the one with worst performance.

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Section: Discussionmentioning

confidence: 99%

Carboplatin Dosing Accuracy by Estimation of Glomerular Filtration versus Creatinuria in Cancer Patients

2018

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“…The CG equation is generally not recommended when carboplatin is administered, and previous reports have shown that the MDRD equation is better for this purpose [15]. Lately, both the National Kidney Education Program and FDA have recommended the use of estimations of GFR based on serum creatinine for drug dosing.…”

Section: Discussionmentioning

confidence: 99%

A New Equation for Estimating Glomerular Filtration Rate in Cancer Patients

Giglio¹

2014

Chemotherapy

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Background: The accuracy of the Cockcroft-Gault (CG) equation, the Modification of Diet in Renal Disease (MDRD) equation and the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation in cancer patients was tested. An equation for estimating glomerular filtration rate (GFR) was created that was adapted to cancer patients. Methods: Data from 641 oncology patients referred for ⁵¹Cr-EDTA measurements were included. Factors that may affect GFR, i.e. gender, hypertension, diabetes, non-steroid anti-inflammatory drugs (NSAID), exposure to chemotherapy, age, weight, height, BMI, body surface area and creatinine value were correlated to ⁵¹Cr-EDTA-measured GFR. The significant factors were then included in a multiple regression analysis correlated to the measured GFR (mGFR). Results: The equation of log₁₀ (GFR; ml/min/1.73 m²) = 2.36-0.33*log₁₀ (age) - 0.78*log₁₀ (creatinine) + 0.87*log₁₀ (weight) - 0.03*NSAID*log₁₀ (creatinine) + gender (1 = female, 0 = male)*(0.05*NSAID - 0.003*BMI) was generated. Expressed as a mean (standard deviation) of mGFR <60 ml/min/1.73 m², this equation, the ‘New Equation', overestimated GFR by 26 (33)%, while CG, MDRD and CKD-EPI overestimated GFR by 26 (40)%, 32 (42)% and 48 (47)%, respectively. For mGFR ≥60 ml/min/1.73 m², the New Equation underestimated GFR by only 3 (16)%, while CG, MDRD and CKD-EPI overestimated GFR by 12 (25)%, 10 (26)% and 5 (23)%, respectively. Conclusion: This study describes a novel equation with a higher accuracy than other commonly used GFR equations for estimating GFR in cancer patients.

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“…Toutes ces é tudes sont cependant des simulations et nous en ré sumons les principales dans le Tableau 2 [49,50,52,[54][55][56][57][66][67][68][69][70][71][72][73][74][75][76][77][78][79][80][81][82][83][84]. À la vue de ce tableau, le moins que l'on puisse dire est que les é tudes ne sont pas toujours d'une qualité mé thodologique irré prochable (notamment en termes de « cré atinine »), que les mé thodologies et les simulations sont parfois assez diffé rentes, et enfin que les ré sultats de ces publications, en termes du choix de la formule, sont trè s contradictoires.…”

Section: Le Choix De La Formule : Que Nous Dit La Litte´rature ?unclassified

Adaptation posologique des médicaments et fonction rénale : quel(s) estimateur(s) faut-il choisir ?

Delanaye

Flamant

Guerber³

et al. 2016

Néphrologie & Thérapeutique

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Le choix de la formule d'estimation du dé bit de filtration glomé rulaire (DFG) à utiliser pour l'adaptation posologique fait encore dé bat, principalement entre la formule de Cockcroft et les é quations plus ré centes, MDRD (pour Modified Diet in Renal Disease) et CKD-EPI (pour Chronic Kidney Disease Epidemiology). Les arguments mis en avant en faveur de l'utilisation de la formule de Cockcroft sont : qu'elle a é té pré fé rentiellement utilisé e pour dé cider des adaptations posologiques avant la mise sur le marché des mé dicaments, qu'elle permettrait une meilleure pré diction du risque de survenue des effets indé sirables à l'accumulation des mé dicaments, qu'elle permettrait de limiter le surdosage mé dicamenteux chez la personne âgé e. Dans cet article d'opinion, nous discutons les faiblesses de l'argumentaire des partisans du maintien de l'utilisation de la formule de Cockcroft dans le contexte de l'adaptation posologique, ainsi que les limites et le manque de fiabilité de cette formule. Nous soutenons la recommandation de la Haute Autorité de santé (HAS) sur l'utilisation systé matique, en 2015, de l'é quation CKD-EPI pour l'estimation du DFG. Lorsque le DFG est é valué dans le but d'adapter la posologie d'un mé dicament, la dé sindexation de la surface corporelle est pré fé rable. Compte tenu des difficulté s d'estimation du DFG chez la personne âgé e et chez les individus à gabarit hors norme, nous recommandons d'utiliser en priorité dans ces populations, des mé dicaments pour lesquels un suivi pharmacologique est disponible, ou d'avoir recours à une mé thode de ré fé rence de mesure du DFG.ß 2015 Association Socié té de né phrologie. Publié par Elsevier Masson SAS. Tous droits ré servé s.

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Evaluation of predictive formulae for glomerular filtration rate for carboplatin dosing in gynecological malignancies

Cited by 47 publications

References 48 publications

Carboplatin Dosing Accuracy by Estimation of Glomerular Filtration versus Creatinuria in Cancer Patients

Carboplatin Dosing Accuracy by Estimation of Glomerular Filtration versus Creatinuria in Cancer Patients

A New Equation for Estimating Glomerular Filtration Rate in Cancer Patients

Adaptation posologique des médicaments et fonction rénale : quel(s) estimateur(s) faut-il choisir ?

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