Evaluation of Prognostic Impact of Soluble CD14 in B-Chronic Lymphocytic Leukemia

Al-Kahiry, Waiel; Sharshira, H. M.; Ghanem, Ahmed I; El-Gammal, Maha; Mikhael, Irene Lewis

doi:10.1007/s12288-016-0745-0

Cited by 2 publications

(2 citation statements)

References 32 publications

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“…Синтез СРБ при воспалении повышается под влиянием активированных цитокинов (интерлейкин-1, 6, 8, фактор некроза опухоли α), являющихся индукторами повышенной продукции СРБ гепатоцитами. Есть информация о больной тяжелой НКИ с большим объемом легочного поражения и низкими показателями ферритина, интерлейкина-6, СРБ [19].…”

Section: Discussionunclassified

Exudative pericarditis with tamponade after COVID-19. Case report

Dvoretsky,

Rachina,

Poltavskaya

et al. 2023

Terapevticheskii arkhiv

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A description of a COVID-19 patient with the development of exudative pericarditis complicated by cardiac tamponade is provid. A peculiarity of this case is the presence of an underlying disease in the patient (chronic lymphocytic leukemia), which was in remission for 1.5 years after chemotherapy. Another feature of the patient was the relatively small area of lung damage and the hemorrhagic nature of the pericardial effusion, which persisted for a long time. The insignificant activity of inflammatory markers was noteworthy. Possible mechanisms of development and features of the course of exudative pericarditis in the described patient, issues of diagnosis and treatment of this category of patients are discusse.

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Section: Discussionunclassified

Exudative pericarditis with tamponade after COVID-19. Case report

Dvoretsky,

Rachina,

Poltavskaya

et al. 2023

Terapevticheskii arkhiv

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“…Reportedly, some clinical, genetic, and immunological features could be used as indicators to monitor the prognosis and response to CLL treatment. For instance, serum IL‐10 concentration in patients with CLL could be used as a surrogate marker for disease progression 3 . Also, it is associated with advanced stage of multiple myeloma patients 4 .…”

Section: Introductionmentioning

confidence: 99%

Molecular characteristics in Chinese with chronic lymphocytic leukemia by next‐generation sequencing: A single‐center retrospective analysis

Cao

Chen

Tao

et al. 2023

Int J Lab Hematology

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IntroductionAlthough the prevalence of Asian chronic lymphocytic leukemia (CLL) patients is not as high as that of Caucasians, there are more atypical CLLs in Asia whose genetic characteristics and their clinical significance are distinct and remain unclear.MethodsA retrospective analysis of 85 CLL samples in our center was conducted from 2019 to 2022. We used next‐generation sequencing with a 172 gene panel to explore the multi‐gene mutational data and the mutational status of immunoglobulin heavy variable (IGHV) gene.ResultsMYD88 (20.0%) was the most frequently mutated gene, much higher than in Europe, followed in order by TP53 (18.8%), NOTCH1 (14.1%), IGLL5 (11.8%), and DNMT3A (8.2%). In addition, the incidence of ATM and SF3B1 mutations was relatively lower in our centre compared to Europe. Mutated (M)‐IGHV patients were more likely to have a cooccurrence of MYD88 mutation, while complex karyotype and DNMT3A mutation were more common in the unmutated (U)‐IGHV group. MYD88 mutated CLL was characterized by prevalence in young males in high‐risk staging, with isolated 13q deletion and concomitant mutation of IGLL5. CLL patients with MYD88 and TP53 mutation showed an unfavorable prognosis.ConclusionThese results would be valuable in helping to understand the characteristics and significance of cytogenetic genetics in Chinese patients with CLL.

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Evaluation of Prognostic Impact of Soluble CD14 in B-Chronic Lymphocytic Leukemia

Cited by 2 publications

References 32 publications

Exudative pericarditis with tamponade after COVID-19. Case report

Exudative pericarditis with tamponade after COVID-19. Case report

Molecular characteristics in Chinese with chronic lymphocytic leukemia by next‐generation sequencing: A single‐center retrospective analysis

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