Evaluation of prolidase activity and oxidative stress in patients with oral lichen planus and oral lichenoid contact reactions

Batu, Şule; Ofluoğlu, Duygu; Ergün, Selma Sönmez; Warnakulasuriya, Saman; Uslu, Ezel; Güven, Yegane; Tanyeri, Hakkı

doi:10.1111/jop.12391

Cited by 25 publications

(18 citation statements)

References 43 publications

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“…These data highlight the potential of NAC for clinical application as an osteogenic enhancer in bone regeneration therapies. Significantly higher salivary ROS, lipid peroxidation, and NO and nitrite levels are present in oral lichen planus patients [ 34 ], suggesting antioxidants such as NAC have therapeutic potential in managing this disease.…”

Section: Antioxidation Activitymentioning

confidence: 99%

Biological Activities and Potential Oral Applications of N‐Acetylcysteine: Progress and Prospects

Pei

Liu

Yang

et al. 2018

Oxidative Medicine and Cellular Longevity

131

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N-Acetylcysteine (NAC), a cysteine prodrug and glutathione (GSH) precursor, has been used for several decades in clinical therapeutic practices as a mucolytic agent and for the treatment of disorders associated with GSH deficiency. Other therapeutic activities of NAC include inhibition of inflammation/NF-κB signaling and expression of proinflammatory cytokines. N-Acetylcysteine is also a nonantibiotic compound possessing antimicrobial property and exerts anticarcinogenic and antimutagenic effects against certain types of cancer. Recently, studies describing potentially important biological and pharmacological activities of NAC have stimulated interests in using NAC-based therapeutics for oral health care. The present review focused on the biological activities of NAC and its potential oral applications. The potential side effects of NAC and formulations for drug delivery were also discussed, with the intent of advancing NAC-associated treatment modalities in oral medicine.

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Section: Antioxidation Activitymentioning

confidence: 99%

Biological Activities and Potential Oral Applications of N‐Acetylcysteine: Progress and Prospects

Pei

Liu

Yang

et al. 2018

Oxidative Medicine and Cellular Longevity

131

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“…In general, several predisposing factors including immunity, infection, genetics, stress and endocrine have been implicated in OLP generating and progressing. Recent studies reported an increased prolidase activity and oxidative stress in patients with OLP, implicating an imbalance in the antioxidant defense system (Ergun et al, 2011;Batu et al, 2016). Although the precise etiology is still unclear, evidence points out that OLP is an immunological process which is triggered by an unknown antigen that alters the basal keratinocytes of the oral mucosa and these changes make the keratinocytes susceptible to cell immune response (Ismail et al, 2007;Payeras et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

Dysbiosis of oral buccal mucosa microbiota in patients with oral lichen planus

Gong

Shi

et al. 2017

Oral Diseases

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“…The role of oxidative stress in the molecular etiology of OLP has been highlighted by recent studies (38,39). As evidence of oxidative stress, patients with OLP have high levels of lipid peroxidation products such as malondialdehyde (MDA) and 4-hydroxy-2-nonenal (40,41). Although their role in OLP is not clear, these oxidative stress markers trigger a sequence of biological responses (including apoptosis initiation) by influencing the levels of B-cell lymphoma 2 and BCL2-associated X proteins, the recruitment of pro-inflammatory T-lymphocytes and nuclear localization and activity of factor kappa B (42,43).…”

Section: Resultsmentioning

confidence: 99%

Oxidative Stress and Oral Mucosal Diseases: An Overview

Sardaro

Vella

Incalza

et al. 2019

In Vivo

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Background: Reactive oxygen species (ROS) and free radicals are physiologically produced during cellular metabolism. When their balance is disrupted in favor of ROS, a condition called oxidative stress occurs. Oxidative stress represents a widespread phenomenon involved in several pathological conditions. The aim of the present review was to report current knowledge on oxidative stress related to oral mucosal diseases. Materials and Methods: Articles from 2000 to 2018 were selected for relevance, validity and quality, from results obtained in PubMed, MEDLINE and Google Scholar using the following search terms: oxidative stress and oral lichen, oral pemphigus, aphthous stomatitis, oral leukoplakia, oral cancer, oral squamous cell carcinoma and oral carcinoma. All articles were independently screened for eligibility by the authors. Results: This narrative review integrates extensive information from all relevant published studies focusing on oxidative stress in oral mucosal diseases. We outline the pathogenetic function of oxidative stress in the most frequent inflammatory, potentially malignant and malignant diseases of the oral mucosa and provide detailed findings from human research. Conclusion: Although variability in findings between individual studies exists, it justifies the conclusion that oxidative stress is a significant process in the oral mucosal diseases pathogenesis.

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Evaluation of prolidase activity and oxidative stress in patients with oral lichen planus and oral lichenoid contact reactions

Cited by 25 publications

References 43 publications

Biological Activities and Potential Oral Applications of N‐Acetylcysteine: Progress and Prospects

Biological Activities and Potential Oral Applications of N‐Acetylcysteine: Progress and Prospects

Dysbiosis of oral buccal mucosa microbiota in patients with oral lichen planus

Oxidative Stress and Oral Mucosal Diseases: An Overview

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