Evaluation of protective effect of myricetin, a bioflavonoid in dimethyl benzanthracene-induced breast cancer in female Wistar rats

Abstract

Background:Breast cancer is one of the most common cancers worldwide. Alarmingly, the incidence of breast cancer is rising rapidly in India.Aim:The present research was focused to assess the role of myricetin; a bioflavonoid in 7,12-dimethylbenzanthracene (DMBA)-induced breast cancer in female Wistar rats.Materials and Methods:A total of 36 female Wistar rats (total 6 groups, n = 6 per group) 6 - 8 weeks old, weighing 150 gm were used in the study. DMBA was given at the dose of 7.5 mg/kg subcutaneously in the mammary region once a week for 4 consecutive weeks in group 2. Vincristine was given in the dose of 500 μg/kg intraperitonially every week for 4 consecutive weeks in group 3. Myricetin was given orally in a dose of 50, 100, and 200 mg/kg in group 4, 5, and 6 respectively. The statistical significance of the data was determined using one way analysis of variance and Duncan's multiple range test.Results:The result showed that myricetin increased the antioxidant levels in plasma, erythrocyte lysate, and breast tissue and was effective in preventing the oxidative damage induced by the carcinogen DMBA. Myricetin 50, 100, and 200 mg/kg/oral for 120 days treated animal resulted comparable results to that of standard vincristine and control groups.Conclusions:Myricetin was found to be either equieffective or more effective than vincristine in all the parameters studied. Myricetin proved the capacity of flavonols to act as antioxidant in cells represents a potential treatment in the field of oncology.

Solubility Enhancement of Myricetin by Inclusion Complexation with Heptakis-O-(2-Hydroxypropyl)-β-Cyclodextrin: A Joint Experimental and Theoretical Study

“…However, myricetin is nearly insoluble in water [13,14], leading to low bioavailability. Thus, myricetin is usually administered orally as aqueous suspensions, reducing its clinical applications [15].…”

Breast Cancer and Flavonoids as Treatment Strategy

“…[32]. The dietary intake of myricetin from our foods is about 0.98-1.1 mg per day, which is quite higher than some other flavonols [33]. Recent studies showed that myricetin is an antioxidant and it possesses cytoprotective, anticarcinogenic, antiviral, and antimicrobial effects [34].…”

Bioactive Compounds: Natural Defense Against Cancer?

“…A recent study showed that microemulsion formulation can improve the solubility of myricetin 1225 times greater than water and also enhance its anti-proliferative activity against human liver cancer cells (HepG2) [92]. Myricetin is a promising anti-carcinogen and chemo preventive agent with therapeutic potential reported in ovarian [93], colon [94], skin [95], liver [96] and breast [97] cancers. Cell-based studies have shown that myricetin inhibited proliferation of T24 bladder cancer cells by inducing cell cycle arrest at the G2/M phase by downregulating cyclin B1 and cyclin-dependent kinase cdc2 [98].…”