Evaluation of pulpal response of deciduous teeth after direct pulp capping with bioactive glass and mineral trioxide aggregate

Haghgoo, Roza; Ahmadvand, Motahare

doi:10.4103/0976-237x.188552

Cited by 18 publications

(7 citation statements)

References 10 publications

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“…The findings of our study are in harmony with some recent clinical trials on the DPC of primary molars. 4 , 21 , 22 , 36 Despite the highly populated mesenchymal cell content of primary molars, the DPC can be a successful conservative treatment if proper case selection is followed, a favorable pulp material is used and the correct procedure is meticulously adhered. However, further clinical trials with longer follow-up periods and larger samples sizes, along with more histological investigations into the material characteristics of this novel cement, seem relevant to derive more definitive conclusions on the successful use of protooth cement for the DPC of primary molars.…”

Section: Discussionmentioning

confidence: 99%

A Randomized Split Mouth Clinical Trial Comparing Mineral Trioxide Aggregate with a New Fast-setting Calcium Silicate Cement in Direct Pulp Capping of Primary Molars: A Preliminary Report from a Long-term Follow-up

Shahamfar

Azima

Erfanparast

2020

International Journal of Clinical Pediatric Dentistry

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A bstract Aims and objectives This study was done to compare the success rate of a novel fast-setting calcium silicate cement (protooth) with mineral trioxide aggregate (MTA) in direct pulp capping (DPC) of primary molars. Materials and methods Forty-five patients with an age range of 5–7 years with 90 bilaterally symmetrical primary molars that had deep carious lesions were incorporated into a randomized split mouth clinical trial. Initially, the caries was removed. Afterward, the teeth randomly underwent DPC with either MTA or protooth. Restoration of the teeth was done by amalgam fillings. Clinical and radiographic examinations were performed after 6 months. To analyze the data, Chi-square statistical test was used. Values < 0.05 were considered statistically significant. Results After 6 months of follow-up, 88 teeth on 44 patients were available for evaluation. The MTA-treated teeth showed a success rate of 95.5%, while the same outcome for the protooth-treated teeth was 93.2%. The difference did not yield a statistically significant difference ( p value > 0.05). Conclusion The findings of this study showed favorable results for the novel calcium silicate cement “protooth” when compared to the outcomes of MTA in the DPC of primary molars. Clinical significance The constant need for the development of more effective materials in the modern pediatric dentistry makes this novel cement of particular interest for pedodontists. The new cement is biocompatible, hydrophilic, and has fast-setting time and adequate tensile strength with favorable clinical results in the DPC of primary molars which can benefit pedodontists in their clinical practice. How to cite this article Shahamfar M, Azima N, Erfanparast L. A Randomized Split Mouth Clinical Trial Comparing Mineral Trioxide Aggregate with a New Fast-setting Calcium Silicate Cement in Direct Pulp Capping of Primary Molars: A Preliminary Report from a Long-term Follow-up. Int J Clin Pediatr Dent 2020;13(4):390–394.

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Section: Discussionmentioning

confidence: 99%

A Randomized Split Mouth Clinical Trial Comparing Mineral Trioxide Aggregate with a New Fast-setting Calcium Silicate Cement in Direct Pulp Capping of Primary Molars: A Preliminary Report from a Long-term Follow-up

Shahamfar

Azima

Erfanparast

2020

International Journal of Clinical Pediatric Dentistry

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“…In contrast with microsized particles, nBGs generate a faster release of soluble ions, which are capable of chemically driving hDPSCs along a mineralization pathway [68]. In addition, the application of microsized BG in a pulp capping procedure in primary human teeth has been shown to promote dentin bridge formation [58].…”

Section: Discussionmentioning

confidence: 99%

“…The specific use of BG in VPT has been explored in animal models, showing the formation of reparative dentin and only mild inflammatory response in pulp capping procedures [55][56][57]. More recently, in a clinical trial on primary teeth, it demonstrated the formation of a dentin bridge [58]. However, there are no commercially available materials with BG currently, nor with nBGs for VPT application.…”

Section: Introductionmentioning

confidence: 99%

Nanoparticles of Bioactive Glass Enhance Biodentine Bioactivity on Dental Pulp Stem Cells

et al. 2021

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This study aimed to investigate the cytotoxicity and bioactivity of a novel nanocomposite containing nanoparticles of bioactive glass (nBGs) on human dental pulp stem cells (hDPSCs). nBGs were synthesized by the sol–gel method. Biodentine (BD) nanocomposites (nBG/BD) were prepared with 2 and 5% wt of nBG content; unmodified BD and glass ionomer cement were used as references. Cell viability and attachment were evaluated after 3, 7 and 14 days. Odontogenic differentiation was assessed with alkaline phosphatase (ALP) activity after 7 and 14 days of exposure. Cells successfully adhered and proliferated on nBG/BD nanocomposites, cell viability of nanocomposites was comparable with unmodified BD and higher than GIC. nBG/BD nanocomposites were, particularly, more active to promote odontogenic differentiation, expressed as higher ALP activity of hDPSCs after 7 days of exposure, than neat BD or GIC. This novel nanocomposite biomaterial, nBG/BD, allowed hDPSC attachment and proliferation and increased the expression of ALP, upregulated in mineral-producing cells. These findings open opportunities to use nBG/BD in vital pulp therapies.

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“…Pulpotomy is the treatment of choice for primary teeth with pulp involvement due to extensive carious lesions. [ 1 2 ] Formocresol is commonly used for pulpotomy of primary teeth through devitalization of dental pulp. After devitalization of dental pulp with formocresol, several materials can be used for capping of the remaining pulp tissue.…”

Section: Discussionmentioning

confidence: 99%

“…It is the treatment of choice for primary teeth with pulp involvement due to extensive caries. [ 1 2 ] Pulpotomy is performed through three methods, namely, devitalization, preservation, and remineralization. Several materials are also used for pulpotomy of teeth.…”

Section: Introductionmentioning

confidence: 99%

Histopathological evaluation of dental pulp of primary teeth pulpotomized with formocresol with/without a capping agent: A randomized clinical trial

Oliadarani

Haghgoo

Mashhadiabbas

et al. 2018

J Int Soc Prevent Communit Dent

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Objectives:This study aimed to assess the reaction of dental pulp of pulpotomized teeth with/without applying a capping agent. This study was performed as randomized clinical trial.Materials and Methods:This split-mouth clinical trial was conducted on eight pairs of primary canine teeth scheduled for extraction as part of orthodontic treatment. The teeth were randomly assigned to the intervention and control groups. In the intervention group, canine teeth were restored with amalgam after pulpotomy with formocresol. In the control group, zinc oxide eugenol paste was applied as the capping agent after pulpotomy with formocresol, and the teeth were then restored with amalgam. After 1 month, the teeth were extracted in both groups and stained with hematoxylin and eosin for histological analysis. Pulp reaction was assessed in terms of pathological parameters. Data were analyzed using the Mann–Whitney U-test and Fisher's exact test. The statistical analysis software was SPSS 16.Results:No significant difference was found between the two groups in terms of inflammation, vitality, internal resorption, bleeding, presence of osteoclasts and dentinoclasts, and internal regeneration. Dentinal bridge did not form in any group.Conclusion:According to the results of this study, formocresol pulpotomy of primary teeth can be completed without the application of a capping agent.

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Evaluation of pulpal response of deciduous teeth after direct pulp capping with bioactive glass and mineral trioxide aggregate

Cited by 18 publications

References 10 publications

A Randomized Split Mouth Clinical Trial Comparing Mineral Trioxide Aggregate with a New Fast-setting Calcium Silicate Cement in Direct Pulp Capping of Primary Molars: A Preliminary Report from a Long-term Follow-up

A Randomized Split Mouth Clinical Trial Comparing Mineral Trioxide Aggregate with a New Fast-setting Calcium Silicate Cement in Direct Pulp Capping of Primary Molars: A Preliminary Report from a Long-term Follow-up

Nanoparticles of Bioactive Glass Enhance Biodentine Bioactivity on Dental Pulp Stem Cells

Histopathological evaluation of dental pulp of primary teeth pulpotomized with formocresol with/without a capping agent: A randomized clinical trial

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