Evaluation of rapidly disintegrating tablets containing glycine and carboxymethylcellulose

Fukami, Jinichi; Yonemochi, Etsuo; Yoshihashi, Yasuo; Terada, Katsuhide

doi:10.1016/j.ijpharm.2005.11.041

Cited by 101 publications

(51 citation statements)

References 12 publications

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“…Fast disintegrating tablet (FDT) dissolves or disintegrates in saliva within seconds when placed on the tongue before it is swallowed [1][2][3][4][5] . Unfortunately, cetirizine dihydrochloride (CTZ) has a very unpleasant bitter taste.…”

Section: Research Papermentioning

confidence: 99%

Cetirizine Dihydrochloride, beta-Cyclodextrin Inclusion Complex by Ethanol Kneading for Taste Masking

Katewongsa¹,

Lertsuphotvanit²,

Phaechamud³

2017

pharmaceutical-sciences

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Katewongsa, et al.: Cetirizine Dihydrochloride and β-Cyclodextrin Complex by Ethanol KneadingCetirizine dihydrochloride has a very unpleasant bitter taste. To mask the bitter taste, complexation with β-cyclodextrin using ethanol as a kneading solvent was investigated and evaluated by Fourier transform infrared spectroscopy, differential scanning calorimetry, powder X-ray diffractometry, thermogravimetric analysis, simultaneous X-ray diffractometry-differential scanning calorimetry measurement and 1 H-nuclear magnetic resonance spectroscopy. Taste was evaluated by human volunteers using an unstructured line scale. The basic characterization of the prepared tablets including in vivo disintegration time and drug dissolution was studied. Fourier transform infrared spectroscopy, differential scanning calorimetry and powder X-ray diffractometry data confirmed the inclusion complex formation. Thermogravimetric analysis, simultaneous X-ray diffractometry-differential scanning calorimetry measurements revealed the reduction of crystalline β-cyclodextrin due to the displacement of water molecules from complex formation. Proton nuclear magnetic resonance spectroscopy indicated an intermolecular interaction between protons of cetirizine dihydrochloride with the cavity of β-cyclodextrin. The prepared complex showed an unstructured line scale with apparent low average rating of 1.70. The inclusion complex-loaded fast disintegrating tablet prepared with direct compression had short disintegration time and good taste with an unstructured line scale with average rating of 0.28. Cetirizine dihydrochloride, β-cyclodextrin inclusion complex was successfully prepared by kneading method using ethanol as solvent. The inclusion complex-loaded fast disintegrating tablet had good taste and good perception in the mouth.

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Section: Research Papermentioning

confidence: 99%

Cetirizine Dihydrochloride, beta-Cyclodextrin Inclusion Complex by Ethanol Kneading for Taste Masking

Katewongsa¹,

Lertsuphotvanit²,

Phaechamud³

2017

pharmaceutical-sciences

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“…4 Therefore, numerous studies on various compositions and manufacturing methods of rapid melt or orally disintegrating or dissolving tablets have been performed. 5,6 The rapidly disintegrating dosage forms usually have an unpleasant taste, local stimulation, and other side effects caused by short, intense exposure to high concentrations of the active agent. Rapid melt tablet (RMTs) is a defined as solid dosage forms that contains medicinal substances, active ingredient and disintegrates rapidly within few seconds without water when placed on the tongue.…”

Section: Introductionmentioning

confidence: 99%

Nano and Microparticulate Chitosan Based System for Formulation of Carvedilol Rapid Melt Tablet

Rv¹,

Pande²,

Sonawane³

2015

Adv Pharm Bull

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“…There are currently 3 classes of orally disintegrating tablet technology, namely, crystallization control, [1][2][3][4] process control [5][6][7] and formulation design. 8,9) Characteristically, technologies for both types of crystallization control and process control improve the disintegrating speed of the tablets. However, the resulting tablets tend to be too soft, and special additives included in the formulations, or special production machinery and complex procedures are required for their production.…”

mentioning

confidence: 99%

Formulation Study for Orally Disintegrating Tablet Using Partly Pregelatinized Starch Binder

Mimura

Kanada

Uchida

et al. 2011

CHEMICAL & PHARMACEUTICAL BULLETIN

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Evaluation of rapidly disintegrating tablets containing glycine and carboxymethylcellulose

Cited by 101 publications

References 12 publications

Cetirizine Dihydrochloride, beta-Cyclodextrin Inclusion Complex by Ethanol Kneading for Taste Masking

Cetirizine Dihydrochloride, beta-Cyclodextrin Inclusion Complex by Ethanol Kneading for Taste Masking

Nano and Microparticulate Chitosan Based System for Formulation of Carvedilol Rapid Melt Tablet

Formulation Study for Orally Disintegrating Tablet Using Partly Pregelatinized Starch Binder

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