Background: This study aimed to observe the agronomic response of 18 Southeast Sulawesi local upland rice cultivars that were grown under two cultivation systems (dry land and wet rice field) and optimize local potential to support self-sufficiency and food security. Methods: The research used a split-plot design with the following main plot: cultivation system (L) including upland (L1) and rice field cultivation system (L2). The subplots were 18 local upland rice cultivars such as Wangkomina (K1), Wuna Lapodidi (K2), Waburi-buri (K3), Wapantoga (K4), Nggalaru (K5), Wuna Parigi (K6), Bakala (K7), Biu (K8), Ikulaku (K9), Bou (K1), Momea (K11), Daindomoronene (K12), Konkep (K13), Tinangge (K14), Ndoamoito (K15), Uwa (K16), Ndowatu (K17) and Indalibana (K18). Result: The local upland rice responded better to the wetland cultivation system than the upland cultivation system. The local upland rice cultivar Ndowatu showed the highest production potential, which was statistically similar to the Biu, Ikulaku, Momea, Konkep and Uwa cultivars. Ndowatu cultivar showed high production potential (842.80 g.m-2). Thus, this cultivar can be considered suitable for development in the rainfed lowlands to increase the planting index and to support the self-sufficiency and food security of the region.