Evaluation of regular insulin adsorption to polypropylene bag and polyvinyl chloride infusion set

Abstract

Aim Clinical application of insulin infusion therapy is usually accomplished with regular human insulin. It is known that the regular insulin adsorbed to the hydrophobic surfaces and different approaches were implemented into the clinical practices. It was aimed to evaluate the rate of adsorption of insulin to polypropylene (PP) bags and polyvinyl chloride (PVC) infusion sets and stability of insulin during the infusion. Methods A 100 IU insulin was added to PP bags containing 100 mL of 0.9% NaCl solution (n = 6). The infusion was started at a rate of 2 mL/h using infusion sets in the PVC structure. Insulin quantification was performed in the samples taken both from the bag and from the end tip of the infusion set during infusion. The stability of insulin solutions stored at room (+25°C) and refrigerator (+4°C) temperatures were compared. Samples were analysed using reverse‐phase high‐performance liquid chromatography. Results No statistically significant difference was found between the concentrations of the samples taken from the bags stored at room and refrigerator temperatures at the 4th, 12th, and 24th hours (P > .05). It was seen that the adsorption rate of insulin to PVC set was 57% and PP bags is at most 5% at the 24th hour. Conclusion When PP bags are used for insulin infusion, it is predicted that 24‐hour change can be made instead of frequent change. In addition, losses caused by the high rate of insulin adsorption to PVC infusion sets should be considered and PP infusion sets would be the better option to use if available.

Sodium Valproate Incompatibility with Parenteral Nutrition Admixtures—A Risk to Patient Safety: An In Vitro Evaluation Study

“…Based on the effect and place of action, interactions may be divided into physicochemical interactions, occurring during drug preparation and administration, and pharmacological interactions, which take place in vivo and alter drug action. Reactions between soluble components and interactions with the container are forms of physicochemical incompatibility [35]. Other known interactions between PNA and anticonvulsants are affected by pharmacokinetics, such as the displacement of drugs from their albumin-binding sites, which may have significant consequences.…”

Real-world study of the leakage of two types of infusion bags in multicenter pharmacy intravenous admixture service (PIVAS)

“…Currently, research on the differences in infusion containers mainly focuses on drug compatibility (Mohr and Kramer, 2022), and most studies have compared PVC infusion bags with non-PVC infusion bags (Rigge and Jones, 2005). For example, studies have reported that PVC infusion bags have certain adsorption for a variety of drugs, which affects the therapeutic effect; therefore, PVC infusion bags should be avoided for clinical use (Sürmelioğlu et al, 2021). However, there is no difference in drug compatibility between non-PVC infusion bags and upright polypropylene infusion bags (Li H. et al, 2019).…”