Evaluation of RES Clearances in Man

Bradfield, J. W. B.

doi:10.1007/978-1-4613-2353-2_8

Cited by 5 publications

(1 citation statement)

References 154 publications

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“…where it is rapidly metabolized, with subsequent release ofthe radioactive label into the circulation [19]. It is unclear by whai receptor, if any, aggregated HSA is taken up [20). Opsonins arc thought not to be involved in their clearance [21].…”

Section: Aggregated Albuminmentioning

confidence: 99%

Untitled

1992

Clinical &Amp; Experimental Immunology

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Section: Aggregated Albuminmentioning

confidence: 99%

Untitled

1992

Clinical &Amp; Experimental Immunology

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Reticuloendothelial failure in chronic intra-abdominal sepsis: The role of opsonic fibronectin

Cheslyn-Curtis

Aldridge

Dudley

1989

Journal of British Surgery

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Severe sepsis leads to depression of the reticuloendothelial (RE) system with delayed bloodstream clearance of particulate matter and bacteria. Fibronectin may be an important opsonin of the RE system and low fibronectin levels often accompany severe sepsis in man. We have investigated the effect of prolonged intra-abdominal sepsis on plasma fibronectin concentrations and RE function. Serial plasma fibronectin concentrations were determined in rabbits for 2 weeks after either the induction of sepsis (appendix abscess) (n = 6) or laparotomy only (n = 6). RE function was measured at 2 weeks by determining the clearance kinetics and organ distribution of low dose technetium tin colloid (TTC). There was an early transient depression in plasma fibronectin values followed by elevated concentrations at 48-72 h which were more marked in the sepsis group. There was a delay in the blood clearance with reduced hepatic and increased bone uptake of TTC. We conclude that depletion of opsonic fibronectin is unlikely to be an important factor contributing to the impairment of RE function associated with intra-abdominal sepsis and that RE depression in septic animals is due to intrinsic Kupffer cell dysfunction.

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Transfusion‐induced immunosuppression and red cell clearance

Donnelly

Proud

Shenton

et al. 1991

Transfusion Medicine

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While blood transfusion is increasingly implicated in the aetiology of tumour recurrence, the mechanism of this effect is unclear. Cancer-bearing patients are known to have factors in their sera which depress the function of normal lymphocytes. It is possible that blood transfusion accentuates this natural suppression. An animal model was therefore developed to study the effect of blood transfusion on humoral immunosuppressive activity and its possible relationship to red cell clearance. WAG rats given a transfusion of chromium-labelled allogeneic but blood-group compatible DA rat blood, developed significantly increased (P < 0.001) levels of lymphocyte suppressive factors in plasma (maximum at 7 days) which coincided with accelerated red cell clearance (t1/2 = 7 days). A transfusion of syngeneic WAG blood caused only a small transient increase in plasma suppression and red cells were cleared at a normal rate (t1/2 = 13 days) consistent with previous studies. However, when syngeneic WAG red cells were lysed and the red cell membranes infused there was a rapid increase in plasma suppression (P < 0.001), similar to but less prolonged than that achieved with allogeneic blood. The immunosuppressive effect of blood transfusion may result from accelerated clearance of allogeneic or damaged syngeneic red blood cells.

show abstract

Evaluation of RES Clearances in Man

Cited by 5 publications

References 154 publications

Untitled

Untitled

Reticuloendothelial failure in chronic intra-abdominal sepsis: The role of opsonic fibronectin

Transfusion‐induced immunosuppression and red cell clearance

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