Evaluation of Retinal Neurodegeneration and Choroidal Thickness in Patients with Inactive Gravesʼ Ophthalmopathy

Kurt, Muhammed; Akpolat, Çetin; Evliyaoglu, Ferhat; Yılmaz, Merve; Ordulu, Fikriye

doi:10.1055/a-1275-0703

Cited by 11 publications

(11 citation statements)

References 30 publications

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“…A recent study by Kurt and colleagues showed that RNLF was thinner only in the superior zone of the patients with GO when compared with healthy controls (p = 0.039). Similar values were noted in the temporal, nasal, and inferior areas [21]. Meirovitch et al demonstrated signi cant thickening of the RNFL in patients with GO compared to controls, unlike the other studies [22].…”

Section: Discussionsupporting

confidence: 59%

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Thicknesses of the retinal layers in patients with Graves’ disease with or without orbitopathy

et al. 2022

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Purpose: Graves' ophthalmopathy (GO) is an in ammatory process that may involve the ocular surface, orbital fat, extraocular muscles, and optic nerves in patients with Graves' disease (GD). We aimed to compare thicknesses of retinal layers in patients with GD with and without GO.Methods: One hundred seven patients with GD (23 with GO (Group1), 84 without GO (Group2)) and eighteen volunteers (Group3) were enrolled. The spectral-domain optical coherence tomography (SD-OCT) is used for ophthalmologic evaluation. Seven retinal layers including retinal nerve fiber layer (RNFL), ganglion cell layer (GCL), inner plexiform layer (IPL), inner nuclear layer (INL), outer plexiform layer (OPL), outer nuclear layer (ONL), retinal pigment epithelium (RPE) were assessed. The thicknesses of layers are compared in groups.Results: The median GCL thickness values in groups 1,2, and 3 were 14 µm, 15 µm, and 17.5 µm, respectively (p = 0.02). The median IPL thickness was 20 µm in group 1, 21 µm in group 2, and 22 µm in group 3 (p = 0.038). The median RPE thickness values in groups 1,2, and 3 were 16 µm, 17 µm and 18.5 µm, respectively. The median GCL, IPL, RPE were different in the groups, while RNLF, INL, OPL, ONL were similar (p>0.05 for each). Conclusion:The median GCL, IPL and RPE were thinner in patients with GO than healthy controls.

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Section: Discussionsupporting

confidence: 59%

“…The average RNFL thickness was not different in patients with GO and healthy controls. Kurt and colleagues did not observe any statistically signi cant difference in the ganglion cell layer between the patients with GO and healthy controls [21]. There are only a few studies that evaluate GCL separately from other layers in patients with GO.…”

Section: Discussionmentioning

confidence: 95%

Thicknesses of the retinal layers in patients with Graves’ disease with or without orbitopathy

et al. 2022

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“…The difference may be related to the relatively low number of patients or other unknown factors. Kurt et al (8) found no statistically significant difference in the ganglion cell layer compared to the control group in their study on 58 patients with GO on RT. Meirovitch et al (20) found a statistically significant decrease in the retinal layer in their study on 21 patients with Thyroidassociated ophthalmopathy (TAO), similar to our study, and similarly, Casini et al (7) found a statistically significant decrease in central retinal thickness in their study on 40 patients with GO.…”

Section: Discussionmentioning

confidence: 78%

“…In addition, dry eye, exposure keratopathy, diplopia and vision loss can be seen due to optic disc compression in the last stage (5,6). There are several studies in the literature on the ocular findings of hyperthyroid patients with ophthalmopathy (7)(8)(9)(10)(11). However, current literature lacks studies on patients without ophthalmopathy.…”

Section: Introductionmentioning

confidence: 99%

Oftalmopatisiz Hipertiroidik Hastalarda Optik Cohorens Tomografi Bulguları

Eski¹,

Teberik

Sezer

et al. 2023

Sağlık Bilimlerinde Değer

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Aim The aim of this study is to compare the choroidal, retinal, and peripapillary nerve fiber layer thickness of the patients diagnosed with hyperthyroidism but did not develop ophthalmopathy with the euthyroid patients. Material and Methods: Thyroid stimulating hormone (TSH), freeT3 (fT3) and freeT4 (fT4) tests of the patients were analyzed. Cases who came in with symptoms of hyperthyroidism and had a TSH lower than 0.5 mu/L were included to the study. Retinal thickness (RT), retinal nerve fiber layer (RNFL) thickness, and choroidal thickness (CT) were calculated by means of spectral domain optical coherence tomography. Results: A total of 82 participants, covering 40 (49%) hyperthyroid patients and 42 (51%) euthyroid healthy individuals, were examined. In terms of RT measurements, T500,T1000,T1500 and N1500 values were found to be lower in the HT group compared to the control group, and they were statistically significant (p

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“…Previous studies have reported that there could be changes in the RNFL thickness in TAO patients even in the inactive phase and before the functional impairment [9]. However, the results have been contradicting [10][11][12][13][14].…”

Section: Introductionmentioning

confidence: 99%

Detection of Dysthyroid Optic Neuropathy by Optical Coherence Tomography

Andrade

FARIA²,

MENEGHIM³

et al. 2022

Preprint

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Objectives: This study aimed to compare the measurements of the peripapillary nerve fiber layer (RNFL) thickness obtained by OCT in patients with TAO and healthy controls and to correlate these parameters with the severity of the orbital disease.Methods: The cross-sectional single-center study consisted of 74 patients (45 with TAO and 29 healthy controls). Patients with TAO underwent a complete ophthalmological examination and were divided according to the clinical activity score (CAS) and European Group Graves' Orbitopathy severity (EUGOGO) classification. Spectral-domain OCT assessed the measurements of the peripapillary RNFL. Results: There was no statistical difference between the groups regarding demographic characteristics and comorbidities (p>0.05%). According to CAS, 93.3% of patients with TAO were in the inactive phase. By the EUGOGO, 27% had mild TAO, 66% had moderate-to-severe, and 7% had very severe disease. The mean peripapillary RNFL thickness was thinnest in the temporal quadrant in the TAO group (p<0.05). There was a strong association between the severity of TAO and the reduction in peripapillary RNFL thickness (p<0.001), except in the nasal quadrant. Conclusion: These results suggest that OCT can be a valuable tool in detecting early changes in peripapillary RNFL in patients with TAO, even in the inactive phase when neuropathy is not yet clinically detectable. These parameters appear to be potential adjuncts in the follow-up of patients, especially when there is a risk of visual loss.

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Evaluation of Retinal Neurodegeneration and Choroidal Thickness in Patients with Inactive Gravesʼ Ophthalmopathy

Cited by 11 publications

References 30 publications

Thicknesses of the retinal layers in patients with Graves’ disease with or without orbitopathy

Thicknesses of the retinal layers in patients with Graves’ disease with or without orbitopathy

Oftalmopatisiz Hipertiroidik Hastalarda Optik Cohorens Tomografi Bulguları

Detection of Dysthyroid Optic Neuropathy by Optical Coherence Tomography

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