Evaluation of retrobulbar blood flow by color doppler ultrasonography after intravitreal ranibizumab injection in patients with neovascular age‐related macular degeneration

Şakalar, Yıldırım Bayezit; Şentürk, Senem; Yıldırım, Mehmet; Keklíkçí, Uğur; Alakuş, Mehmet Fuat; Ünlü, Kaan

doi:10.1002/jcu.21989

Cited by 8 publications

(2 citation statements)

References 39 publications

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“…It is worth noting the possible influence of anti-VEGF treatment on TRBF in the eyes with DME because anti-VEGF agents have been linked to transient reductions in RBF . For the 6 eyes that received anti-VEGF treatment, the injections were given based on a treat-and-extend protocol.…”

Section: Discussionmentioning

confidence: 99%

En Face Doppler Optical Coherence Tomography Measurement of Total Retinal Blood Flow in Diabetic Retinopathy and Diabetic Macular Edema

et al. 2017

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to the New England Eye Center) from Carl Zeiss Meditec and Optovue and serving as a consultant to Regeneron and Genentech. Dr Baumal reports serving as a speaker for Allergan and Genetech, as well as having received compensations from Optovue. Dr Duker reports receiving grants from Carl Zeiss Meditec and Optovue while also serving as a consultant to Carl Zeiss Meditec and Optovue. Dr Duker also reports serving as a consultant to Allergan, Aura Biosciences, Lumenis, Omeros, Santen, Thrombogenics, and Ocudyne; being a stock holder in Hemera Biosciences and Ophthotech; and being on the board of directors of Eleven Biotherapeutics and pSivida Corporation. Dr Fujimoto reports having a personal financial interest in Optovue and also receiving royalties from a patent owned by the Massachusetts Institute of Technology and licensed to Optovue. Dr Fujimoto and Mr Moult report receiving grants from the National Institutes of Health and the Air Force Office of Scientific Research during the conduct of the study. Dr Choi reports receiving grants from the National Institutes of Health during the conduct of the study. No other disclosures are reported.

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Section: Discussionmentioning

confidence: 99%

En Face Doppler Optical Coherence Tomography Measurement of Total Retinal Blood Flow in Diabetic Retinopathy and Diabetic Macular Edema

et al. 2017

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“…The higher the PSV and EDV are, the more sufficient the blood supply is (20). RI and PI reflect the blood flow resistance of blood vessels and are negatively related to vascular compliance (21). The results demonstrated that anti-VEGF drugs, combined with PDT, can optimize blood flow state, which is the fundamental mechanism behind vision changes in patients.…”

Section: Discussionmentioning

confidence: 99%

Effect of anti-VEGF drugs combined with photodynamic therapy in the treatment of age-related macular degeneration

Dong

Wan

Yan

et al. 2016

Experimental and Therapeutic Medicine

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We analyzed the effects of anti-vascular endothelial growth factor (VEGF) drugs combined with photodynamic therapy (PDT) in the treatment of age-related macular degeneration (AMD). Ninety-six cases (192 eyes) of AMD were included in this study and randomly divided into the observation group and control group (n=48 cases per group). The control group was administered the treatment of Lucentis intravitreal injection alone and the observation group was administered Lucentis combined with PDT. The therapeutic effects were compared. The best corrected visual acuity of patients in the two groups increased gradually after treatment. Patients in the observation group had a significantly higher visual acuity when compared to the control group 1 and 6 months post-operation. The differences were statistically significant (P<0.05). The proportion of patients with vision improvement in the observation group was higher than that in the control group from 1 to 6 months; differences were statistically significant (P<0.05). Through detection by color Doppler ultrasound within 6 months after treatment, we observed that the peak systolic velocity and arterial end diastolic velocity of retrobulbar optic nerve bitemporal PCA of the observation group were higher than those of the control group. The values of arterial resistance index and pulsatility index of the observation group were lower than those of control group. The differences were statistically significant (P<0.05). Six months after treatment, the value of central foveal thickness of the observation group was lower than that of the control group, the value of mean sensitivity of visual field parameter 10° and 4° was higher in the observation group than in the control group, and the absolute value of mean defects in the observation group were lower than that of the control group. In summary, the differences were statistically significant (P<0.05). Anti-VEGF drugs combined with PDT can optimize the overall vision of patients with AMD, improve hemodynamic parameters and reduce visual field defects.

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Assessment of flow dynamics in retinal and choroidal microcirculation

Wei

Balne

Meissner

et al. 2018

Survey of Ophthalmology

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Alterations in ocular blood flow have been implicated in mechanisms that lead to vision loss in patients with various ocular disorders such as diabetic retinopathy, glaucoma, and age-related macular degeneration. Assessment of retinal and choroidal blood flow is also a window to evaluate systemic diseases that affect microvasculature. Quantification and qualification of the blood flow in the retina and choroid help us understand pathophysiology, stratify disease risk, and monitor disease progression in these disorders. Multiple methods are used by researchers for assessment of blood flow, but a gold standard is lacking. We review commonly used methods, both invasive and noninvasive, for evaluation of blood flow, including intravital microscopy, laser Doppler velocimetry, laser Doppler flowmetry, laser interferometry, confocal scanning laser Doppler flowmetry, laser speckle flowgraphy, Doppler optical coherence tomography, blue-field entoptic simulation, retinal vessel caliber assessment, optical coherence tomography angiography, retinal function imaging, color Doppler imaging, and scanning laser ophthalmoscope angiogram. As technology evolves, better evaluation of blood flow in various ocular and systemic diseases will likely bring new perspectives into clinical practice and translate to better diagnosis and treatment.

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Evaluation of retrobulbar blood flow by color doppler ultrasonography after intravitreal ranibizumab injection in patients with neovascular age‐related macular degeneration

Abstract: Intravitreal ranibizumab injection for neovascular AMD does not cause a significant change in the retrobulbar blood flow in either the injected eye or the fellow eye.

Cited by 8 publications

References 39 publications

En Face Doppler Optical Coherence Tomography Measurement of Total Retinal Blood Flow in Diabetic Retinopathy and Diabetic Macular Edema

En Face Doppler Optical Coherence Tomography Measurement of Total Retinal Blood Flow in Diabetic Retinopathy and Diabetic Macular Edema

Effect of anti-VEGF drugs combined with photodynamic therapy in the treatment of age-related macular degeneration

Assessment of flow dynamics in retinal and choroidal microcirculation

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