Evaluation of Riboflavin Intakes and Status of 20–64-Year-Old Adults in South Korea

Choi, Ji Young; Kim, Young Nam; Cho, Youn‐Ok

doi:10.3390/nu7010253

Cited by 23 publications

(20 citation statements)

References 29 publications

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“…Riboflavin (vitamin B 2 ) is a water-soluble vitamin that is involved in a number of oxidative enzyme systems in electron transport (161). Flavin mononucleotide and flavin adenine dinucleotide are riboflavin coenzymes involved in diverse redox reactions in human metabolism and work as electron carriers (162) in carbohydrate, lipid, and other B vitamins and drug metabolism (163).…”

Section: Riboflavinmentioning

confidence: 99%

Nutrition and Atherosclerosis

Torres

Guevara‐Cruz

Velázquez-Villegas

et al. 2015

Archives of Medical Research

223

137

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Section: Riboflavinmentioning

confidence: 99%

Nutrition and Atherosclerosis

Torres

Guevara‐Cruz

Velázquez-Villegas

et al. 2015

Archives of Medical Research

223

137

View full text Add to dashboard Cite

“…A systematic review including data from adults ≥65 years ( n 28 000) in Europe, North America, Australia and New Zealand concluded that 41 % of males and 31 % of females had dietary intake values below the estimated average requirement, with riboflavin identified as one of six nutrients considered to be a possible public health concern ( 56 ) . Similarly in Asia, a number of large population-based studies and national dietary surveys have reported inadequate riboflavin intakes ( 57 – 59 ) . It has been suggested that the Chinese population tend to excrete very little riboflavin and thus their requirement may be lower than that of other populations ( 60 ) ; however, this requires further investigation.…”

Section: Riboflavin Status: the Global Picturementioning

confidence: 99%

Riboflavin status, MTHFR genotype and blood pressure: current evidence and implications for personalised nutrition

et al. 2016

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Clinical deficiency of the B-vitamin riboflavin (vitamin B 2 ) is largely confined to developing countries; however accumulating evidence indicates that suboptimal riboflavin status is a widespread problem across the developed world. Few international data are available on riboflavin status as measured by the functional biomarker, erythrocyte glutathione reductase activation coefficient, considered to be the gold standard index. One important role of riboflavin in the form of flavin dinucleotide is as a co-factor for the folate-metabolising enzyme methylenetetrahydrofolate reductase (MTHFR). Homozygosity for the common C677T polymorphism in MTHFR, affecting over 10 % of the UK and Irish populations and up to 32 % of other populations worldwide, has been associated with an increased risk of CVD, and more recently with hypertension. This review will explore available studies reporting riboflavin status worldwide, the interaction of riboflavin with the MTHFR C677T polymorphism and the potential role of riboflavin in personalised nutrition. Evidence is accumulating for a novel role of riboflavin as an important modulator of blood pressure (BP) specifically in individuals with the MTHFR 677TT genotype, with results from a number of recent randomised controlled trials demonstrating that riboflavin supplementation can significantly reduce systolic BP by 5-13 mmHg in these genetically at risk adults. Studies are however required to investigate the BP-lowering effect of riboflavin in different populations and in response to doses higher than 1·6 mg/d. Furthermore, work focusing on the translation of this research to health professionals and patients is also required.Riboflavin: Methylenetetrahydrofolate reductase: MTHFR C677T: Blood pressure:Personalised nutrition Riboflavin (vitamin B 2 ) is a water-soluble B-vitamin defined chemically as 7,8-dimethyl-10-1′-D-ribityl isoalloxazine. It acts as a precursor for FMN and FAD (1) . Clinical riboflavin deficiency is not generally considered to be a problem in the developed world but in recent years evidence has shown that sub-optimal status may be more widespread than generally perceived based on studies reporting the functional biomarker, erythrocyte glutathione reductase activation coefficient (EGRac) generally considered as the gold standard index of status. Few international data are however available based on EGRac and reports on riboflavin status are more commonly based solely on dietary intake data. Although riboflavin is required for numerous metabolic reactions its role (in the form of FAD) as a cofactor for the folatemetabolising enzyme, methylenetetrahydrofolate reductase (MTHFR) has recently received particular attention. Homozygosity (MTHFR 677TT genotype) for a common polymorphism in MTHFR, affecting over 10 % of the UK and Irish populations and up to 32 % of other populations worldwide (2) , has been associated with an increased risk of CVD (3) and more recently with hypertension (4) . Emerging evidence from intervention trials supports a novel role for riboflav...

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“…Riboflavin deficiency is prevalent in many regions over the world, particularly in underdeveloped countries with a low intake of dairy products and meats5678. In the clinical conditions, patients with certain types of cancers and congenital heart disease, as well as those with excessive alcohol intake, are at a greater risk of riboflavin deficiency9.…”

mentioning

confidence: 99%

Riboflavin deficiency induces a significant change in proteomic profiles in HepG2 cells

Xin¹,

Li²,

Gao³

et al. 2017

Sci Rep

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Riboflavin deficiency is widespread in many regions over the world, especially in underdeveloped countries. In this study, we investigated the effects of riboflavin deficiency on protein expression profiles in HepG2 cells in order to provide molecular information for the abnormalities induced by riboflavin deficiency. HepG2 cells were cultured in media containing different concentrations of riboflavin. Changes of cell viability and apoptosis were assessed. A comparative proteomic analysis was performed using a label-free shotgun method with LC–MS/MS to investigate the global changes of proteomic profiles in response to riboflavin deficiency. Immunoblotting test was used to validate the results of proteomic approach. The cell viability and apoptosis tests showed that riboflavin was vital in maintaining the cytoactivity of HepG2 cells. The label-free proteomic analysis revealed that a total of 37 proteins showing differential expression (±2 fold, p < 0.05) were identified after riboflavin deficiency. Bioinformatics analysis indicated that the riboflavin deficiency caused an up-regulation of Parkinson’s disease pathway, steroid catabolism, endoplasmic reticulum stress and apoptotic process, while the fatty acid metabolism, tricarboxylic citrate cycle, oxidative phosphorylation and iron metabolism were down-regulated. These findings provide a molecular basis for the elucidation of the effects caused by riboflavin deficiency.

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Evaluation of Riboflavin Intakes and Status of 20–64-Year-Old Adults in South Korea

Cited by 23 publications

References 29 publications

Nutrition and Atherosclerosis

Nutrition and Atherosclerosis

Riboflavin status, MTHFR genotype and blood pressure: current evidence and implications for personalised nutrition

Riboflavin deficiency induces a significant change in proteomic profiles in HepG2 cells

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