Evaluation of risk of secondary cancer occurrence after proton radiotherapy of ocular tumours

Stolarczyk, Liliana; Cywicka-Jakiel, T.; Horwacik, Tomasz; Olko, P.; Swakoń, Jan; Waligórski, M.P.R.

doi:10.1016/j.radmeas.2011.05.046

Cited by 13 publications

(37 citation statements)

References 14 publications

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“…The UAB extended-range BSS is based on a cylindrical (9 mm diameter, 10 mm high) 3 He filled (partial pressure of 800 kPa) proportional counter (model 05NH1 from EURISYS) and includes 9 PE-spheres with diameter ranging from 2.5 ′′ to 12 ′′ . It also includes two 7 ′′ PE extended-range sphere with 1 ′′ Cu or 1 ′′ Pb shell as well as three PE spheres (2.5 ′′ , 3 ′′ , and 4.2 ′′ ) with 1.5 mm Cd shell.…”

Section: B2 Uab Bonner Sphere Spectrometry Systemmentioning

confidence: 99%

“…Similarly, the WENDI-II is an improved 13.5 kg survey meter 15 with a cylindrical boron-doped polyethylene moderator (22.9 cm in diameter and 21 cm long), and a central cylindrical 3 He proportional counter. The moderator encloses a tungsten powder shell (1.5 cm in thickness) improving the instrument's response to high-energy neutrons up to 5 GeV.…”

Section: C3 Wendi-ii Survey Metermentioning

confidence: 99%

“…In all subsequent comparisons, the reference H * (10) value is given by the HMGU extended-range BSS system since the latter was previously calibrated with monoenergetic neutron beams of up to 387 MeV (Ref. 22), and H * (10) measurements were made with this detector set at all positions (1)(2)(3)(4). One should finally note that both BSS systems involve a dead time factor below 40 µs implicating a negligible error.…”

Section: C1 Bonner Sphere Systemsmentioning

confidence: 99%

“…Such out-of-field doses in proton therapy are mainly due to secondary neutron and gamma radiation which may increase the probability of late effects including the generation of secondary cancers. [1][2][3] Neutrons are of particular concern owing to their high relative biological effectiveness 4 and have thus been extensively studied in the past. [5][6][7][8] Neutron ambient dose-equivalent, H * (10) has been measured by several authors using a wide variety of proportional counters.…”

Section: Introductionmentioning

confidence: 99%

“…5,8,10,11 Neutron organ dose measurements have also been conducted using passive detectors such as superheated emulsions (bubble detectors), thermoluminescent detector (TLD), and solid state nuclear track detector (SSNTD) mainly. 3,8,[12][13][14] On the one hand, all these studies have shown that stray neutron radiation involved in proton therapy is not negligible (up to 10 mSv/proton Gy outside the clinical target volume), is facility dependent (with major effects arising from beam line elements and shielding design), and implicates neutrons of high energy (equal to the proton beam energy). On the other hand, these studies have confirmed that measuring stray radiation and estimating patients' exposure remain very challenging owing to the complexity of the radiation field.…”

Section: Introductionmentioning

confidence: 99%

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Measurement of stray radiation within a scanning proton therapy facility: EURADOS WG9 intercomparison exercise of active dosimetry systems

et al. 2015

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Section: B2 Uab Bonner Sphere Spectrometry Systemmentioning

confidence: 99%

Section: C3 Wendi-ii Survey Metermentioning

confidence: 99%

Section: C1 Bonner Sphere Systemsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Measurement of stray radiation within a scanning proton therapy facility: EURADOS WG9 intercomparison exercise of active dosimetry systems

et al. 2015

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Modelling and measurements of distributions in an adult human phantom undergoing proton scanning beam radiotherapy: lung- and prostate-located tumours

Puchalska

2021

Radiat Environ Biophys

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Proton radiotherapy has been shown to offer a significant dosimetric advantage in cancer patients, in comparison to conventional radiotherapy, with a decrease in dose to healthy tissue and organs at risk, because the bulk of the beam energy is deposited in the Bragg peak to be located within a tumour. However, it should be kept in mind that radiotherapy of cancer is still accompanied by adverse side effects, and a better understanding and improvement of radiotherapy can extend the life expectancy of patients following the treatment of malignant tumours. In this study, the dose distributions measured with thermoluminescent detectors (TLDs) inside a tissue-equivalent adult human phantom exposed for lung and prostate cancer using the modern proton beam scanning radiotherapy technique were compared. Since the TLD detection efficiency depends on the ionization density of the radiation to be detected, and since this efficiency is detector specific, four different types of TLDs were used to compare their response in the mixed radiation fields. Additionally, the dose distributions from two different cancer treatment modalities were compared using the selected detectors. The measured dose values were benchmarked against Monte Carlo simulations and available literature data. The results indicate an increase in the lateral dose with an increase of the primary proton energy. However, the radiation quality factor of the mixed radiation increases by 20% in the vicinity to the target for the lower initial proton energy, due to the production of secondary charged particles of low-energy and short range. For the cases presented here the MTS-N TLD detector seems to be the most optimal tool for dose measurements within the target volume, while the MCP-N TLD detector, due to an interplay of its enhanced thermal neutron response and decreased detection efficiency to highly ionising radiation, is a better choice for the out-of-field measurements. The pairs of MTS-6 and MTS-7 TLDs used also in this study allowed for a direct measurement of the neutron dose equivalent. Before it can be concluded that they offer an alternative to the time-consuming nuclear track detectors, however, more research is needed to unambiguously confirm whether this observation was just accidental or whether it only applies to certain cases. Since there is no universal detector, which would allow the determination of the dosimetric quantities relevant for risk estimation, this work expands the knowledge necessary to improve the quality of dosimetry data and might help scientists and clinicians in choosing the right tools to measure radiation doses in mixed radiation fields.

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Introduction to dosimetry and risk estimation of second cancer induction following radiotherapy

Harrison

2013

Radiation Measurements

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Evaluation of risk of secondary cancer occurrence after proton radiotherapy of ocular tumours

Cited by 13 publications

References 14 publications

Measurement of stray radiation within a scanning proton therapy facility: EURADOS WG9 intercomparison exercise of active dosimetry systems

Measurement of stray radiation within a scanning proton therapy facility: EURADOS WG9 intercomparison exercise of active dosimetry systems

Modelling and measurements of distributions in an adult human phantom undergoing proton scanning beam radiotherapy: lung- and prostate-located tumours

Introduction to dosimetry and risk estimation of second cancer induction following radiotherapy

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